scholarly journals Characteristics of Ascorbic Acid Metabolism in Scurvy-Prone Spontaneously Hypertensive Rat, SHR-od

2003 ◽  
Vol 49 (1) ◽  
pp. 1-6
Author(s):  
Kaori KAWAI ◽  
Naoko NISHIO ◽  
Fumihiko HORIO
Keyword(s):  
Ascorbic Acid ◽  
Acid Metabolism ◽  
Spontaneously Hypertensive Rat ◽  
Spontaneously Hypertensive ◽  
Hypertensive Rat

scholarly journals Longitudinal Evaluation of Fatty Acid Metabolism in Normal and Spontaneously Hypertensive Rat Hearts with Dynamic MicroSPECT Imaging

2011 ◽  
Vol 2011 ◽  
pp. 1-12 ◽  
Author(s):  
Bryan W. Reutter ◽  
Ronald H. Huesman ◽  
Kathleen M. Brennan ◽  
Rostyslav Boutchko ◽  
Stephen M. Hanrahan ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Spontaneously Hypertensive Rat ◽  
Projection Data ◽  
Ct Scanner ◽  
Pinhole Spect ◽  
Time Activity ◽  
Spontaneously Hypertensive ◽  
Hypertensive Rat

The goal of this project is to develop radionuclide molecular imaging technologies using a clinical pinhole SPECT/CT scanner to quantify changes in cardiac metabolism using the spontaneously hypertensive rat (SHR) as a model of hypertensive-related pathophysiology. This paper quantitatively compares fatty acid metabolism in hearts of SHR and Wistar-Kyoto normal rats as a function of age and thereby tracks physiological changes associated with the onset and progression of heart failure in the SHR model. The fatty acid analog, 123I-labeled BMIPP, was used in longitudinal metabolic pinhole SPECT imaging studies performed every seven months for 21 months. The uniqueness of this project is the development of techniques for estimating the blood input function from projection data acquired by a slowly rotating camera that is imaging fast circulation and the quantification of the kinetics of 123I-BMIPP by fitting compartmental models to the blood and tissue time-activity curves.

A newly established strain of spontaneously hypertensive rat with a defect of ascorbic acid biosynthesis

Life Sciences ◽  
2001 ◽  
Vol 69 (16) ◽  
pp. 1879-1890 ◽  
Author(s):  
Fumihiko Horio ◽  
Kaori Hayashi ◽  
Takashi Mishima ◽  
Kumiko Takemori ◽  
Itsuki Oshima ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Spontaneously Hypertensive Rat ◽  
Acid Biosynthesis ◽  
Spontaneously Hypertensive ◽  
Hypertensive Rat ◽  
Ascorbic Acid Biosynthesis

A Linkage Analysis of the Salt-sensitive Hypertensive Gene in the Stroke-prone Spontaneously Hypertensive Rat (SHRSP)

1996 ◽  
Vol 37 (4) ◽  
pp. 553-553
Author(s):  
Tomoji Mashimo ◽  
Yasuo Nara ◽  
Tomoko Tamada ◽  
Chiho Matsumoto ◽  
Katumi Ikeda ◽  
...  
Keyword(s):  
Linkage Analysis ◽  
Spontaneously Hypertensive Rat ◽  
Spontaneously Hypertensive ◽  
Hypertensive Rat
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