scholarly journals Utility of Contrast-Enhanced T2 FLAIR for Imaging Brain Metastases Using a Half-dose High-Relaxivity Contrast Agent

Author(s):  
T. Jin ◽  
M. Ge ◽  
R. Huang ◽  
Y. Yang ◽  
T. Liu ◽  
...  
2010 ◽  
Vol 51 (1) ◽  
pp. 78-84 ◽  
Author(s):  
Biao Huang ◽  
Chang-Hong Liang ◽  
Hong-Jun Liu ◽  
Guang-Yi Wang ◽  
Shui-Xing Zhang

2021 ◽  
Vol 22 (9) ◽  
pp. 4586
Author(s):  
Marta Orts-Arroyo ◽  
Amadeo Ten-Esteve ◽  
Sonia Ginés-Cárdenas ◽  
Isabel Castro ◽  
Luis Martí-Bonmatí ◽  
...  

The paramagnetic gadolinium(III) ion is used as contrast agent in magnetic resonance (MR) imaging to improve the lesion detection and characterization. It generates a signal by changing the relaxivity of protons from associated water molecules and creates a clearer physical distinction between the molecule and the surrounding tissues. New gadolinium-based contrast agents displaying larger relaxivity values and specifically targeted might provide higher resolution and better functional images. We have synthesized the gadolinium(III) complex of formula [Gd(thy)2(H2O)6](ClO4)3·2H2O (1) [thy = 5-methyl-1H-pyrimidine-2,4-dione or thymine], which is the first reported compound based on gadolinium and thymine nucleobase. 1 has been characterized through UV-vis, IR, SEM-EDAX, and single-crystal X-ray diffraction techniques, and its magnetic and relaxometric properties have been investigated by means of SQUID magnetometer and MR imaging phantom studies, respectively. On the basis of its high relaxivity values, this gadolinium(III) complex can be considered a suitable candidate for contrast-enhanced magnetic resonance imaging.


2016 ◽  
Vol 89 (1063) ◽  
pp. 20151050 ◽  
Author(s):  
Yong-Mei Wang ◽  
Wei Fan ◽  
Kai Zhang ◽  
Li Zhang ◽  
Zhen Tan ◽  
...  

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