scholarly journals Comparison of transducers with different frequencies in breast contrast-enhanced ultrasound (CEUS) using SonoVue as contrast agent

2016 ◽  
Vol 89 (1063) ◽  
pp. 20151050 ◽  
Author(s):  
Yong-Mei Wang ◽  
Wei Fan ◽  
Kai Zhang ◽  
Li Zhang ◽  
Zhen Tan ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Contrast Enhanced Ultrasound ◽  
Contrast Enhanced

Contrast-enhanced ultrasound (CEUS) in assessing early response among patients with invasive breast cancer undergoing neoadjuvant chemotherapy

2016 ◽  
Vol 58 (4) ◽  
pp. 394-402 ◽  
Author(s):  
Ariel Saracco ◽  
Botond K Szabó ◽  
Ervin Tánczos ◽  
Jonas Bergh ◽  
Thomas Hatschek
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Contrast Agent ◽  
Real Time ◽  
Invasive Breast Cancer ◽  
Early Response ◽  
Contrast Enhanced Ultrasound ◽  
Time Harmonic ◽  
Contrast Enhanced ◽  
Significant Difference

Background One of the big challenges in onco-radiology is to find a reliable imaging method that may predict early response during the first cycles of any neoadjuvant chemotherapy. Purpose To evaluate the use of real-time harmonic contrast-enhanced ultrasound (CEUS) in predicting early response in breast cancer tumors under neoadjuvant chemotherapy (NAC) treatment. Material and Methods Nineteen consecutive patients with invasive breast cancer were evaluated with a bolus dose of 2.4 mL contrast agent using CEUS, before and after two cycles of epirubicin and docetaxel. The lognormal function was used for quantitative analysis of kinetic data to evaluate early response. Results There was statistically significant difference in time-to-peak ( tp) between responders and non-responders (two sample t-test, P = 0.027) where tp was significantly longer at the week 5 than at the baseline scan among responders when compared to non-responders. Conclusion In-flow of intravascular contrast agent in tumors is significantly slower in responders at real-time harmonic CEUS, and might be effectively used for the evaluation of early response to chemotherapy in invasive breast cancer. However, further investigations in a larger and more heterogeneous population should be performed to corroborate the reliability of the method.

scholarly journals Contrast Enhanced Ultrasound in the Diagnosis and Evaluation of the Efficiency of Chemotherapy in Patients with Colorectal Liver Metastases

2021 ◽  
Vol 101 (6) ◽  
pp. 324-332
Author(s):  
E. V. Kovaleva ◽  
G. T. Sinyukova ◽  
T. Yu. Danzanova ◽  
P. I. Lepedatu ◽  
E. A. Gudilina ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Arterial Phase ◽  
Contrast Enhanced Ultrasound ◽  
Time Curve ◽  
Entire Volume ◽  
Contrast Enhanced ◽  
Group 2 ◽  
Group 1

Objective: to determine the possibilities of contrast-enhanced ultrasound (CEUS) in identifying and evaluating the efficiency of chemotherapy in patients with colorectal liver metastases (CLM).Material and methods. The investigation enrolled 28 patients with CLM. The patients were divided into two groups: Group 1 – 15 pretreatment patients; Group 2 – 13 posttreatment patients with process stabilization. All the patients underwent standard B-mode ultrasound of the liver and that using the contrast agent SonoVue ® (Bracco, Italy), by recording and estimating the parameters of the intensity-time curve (CIV). Liver CEUS assesses the nature of contrasting metastases in three phases (arterial, venous, and delay ones).Results. The investigators identified three types of contrast agent accumulation in CLM in the arterial phase: along the periphery of the lesions (in 60% of the patients of Group 1, in 76.9% in Group 2), homogeneously over the entire volume (in 26.7% in Group 1 and in 0.08% in Group 2), in parallel with intact liver parenchyma (13.3% in Group 1 and 23.02% in Group 2). In the delay phase, more metastases were detected in 4 cases (14.3%). Estimation of CIV parameters showed a difference at the beginning of contrast enhancement stages between the patients in both groups. Group 1 exhibited the early contrasting of liver metastases (19.3 sec); Group 2 displayed the late washout of a contrast agent (65.9 sec).Conclusion. CEUS versus B-mode ultrasound improves the imaging of liver metastases. The change in the vascular architectonics and hemodynamics in CLM after chemotherapy is reflected in the alteration of the rate of contrast accumulation and washout from the metastases, which allows CEUS to be used in the evaluation of the efficiency of this treatment.

scholarly journals Evaluation of Renal Microcirculation by Contrast-Enhanced Ultrasound With SonazoidTM as a Contrast Agent

2010 ◽  
Vol 51 (3) ◽  
pp. 176-182 ◽  
Author(s):  
Kayori Tsuruoka ◽  
Takashi Yasuda ◽  
Kenichiro Koitabashi ◽  
Masahiko Yazawa ◽  
Minako Shimazaki ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Contrast Enhanced Ultrasound ◽  
Renal Microcirculation ◽  
Contrast Enhanced

scholarly journals Contrast enhanced ultrasound imaging by nature-inspired ultrastable echogenic nanobubbles

Nanoscale ◽  
2019 ◽  
Vol 11 (33) ◽  
pp. 15647-15658 ◽  
Author(s):  
Al de Leon ◽  
Reshani Perera ◽  
Christopher Hernandez ◽  
Michaela Cooley ◽  
Olive Jung ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Ultrasound Imaging ◽  
Shell Structure ◽  
Ultrasound Contrast Agent ◽  
Contrast Enhanced Ultrasound ◽  
Ultrasound Contrast ◽  
Contrast Enhanced ◽  
Stress And Deformation

We report an ultrasound contrast agent for which we engineered the shell structure to impart much better stability under intense stress and deformation.

scholarly journals Versatile utilization of real-time intraoperative contrast-enhanced ultrasound in cranial neurosurgery: technical note and retrospective case series

2016 ◽  
Vol 40 (3) ◽  
pp. E6 ◽  
Author(s):  
Ilya Lekht ◽  
Noah Brauner ◽  
Joshua Bakhsheshian ◽  
Ki-Eun Chang ◽  
Mittul Gulati ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Real Time ◽  
Case Series ◽  
Technical Note ◽  
Dynamic Imaging ◽  
Illustrative Case ◽  
Contrast Enhanced Ultrasound ◽  
Primary Tumors ◽  
Contrast Enhanced ◽  
Tumefactive Demyelinating Lesion

OBJECTIVE Intraoperative contrast-enhanced ultrasound (iCEUS) offers dynamic imaging and provides functional data in real time. However, no standardized protocols or validated quantitative data exist to guide its routine use in neurosurgery. The authors aimed to provide further clinical data on the versatile application of iCEUS through a technical note and illustrative case series. METHODS Five patients undergoing craniotomies for suspected tumors were included. iCEUS was performed using a contrast agent composed of lipid shell microspheres enclosing perflutren (octafluoropropane) gas. Perfusion data were acquired through a time-intensity curve analysis protocol obtained using iCEUS prior to biopsy and/or resection of all lesions. RESULTS Three primary tumors (gemistocytic astrocytoma, glioblastoma multiforme, and meningioma), 1 metastatic lesion (melanoma), and 1 tumefactive demyelinating lesion (multiple sclerosis) were assessed using real-time iCEUS. No intraoperative complications occurred following multiple administrations of contrast agent in all cases. In all neoplastic cases, iCEUS replicated enhancement patterns observed on preoperative Gd-enhanced MRI, facilitated safe tumor debulking by differentiating neoplastic tissue from normal brain parenchyma, and helped identify arterial feeders and draining veins in and around the surgical cavity. Intraoperative CEUS was also useful in guiding a successful intraoperative needle biopsy of a cerebellar tumefactive demyelinating lesion obtained during real-time perfusion analysis. CONCLUSIONS Intraoperative CEUS has potential for safe, real-time, dynamic contrast-based imaging for routine use in neurooncological surgery and image-guided biopsy. Intraoperative CEUS eliminates the effect of anatomical distortions associated with standard neuronavigation and provides quantitative perfusion data in real time, which may hold major implications for intraoperative diagnosis, tissue differentiation, and quantification of extent of resection. Further prospective studies will help standardize the role of iCEUS in neurosurgery.

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