scholarly journals Assessment of the Membranous Labyrinth in Infants Using a Heavily T2-weighted 3D FLAIR Sequence without Contrast Agent Administration

2021 ◽  
Vol 42 (2) ◽  
pp. 377-381
Author(s):  
G. Conte ◽  
S. Casale ◽  
L. Caschera ◽  
F.M. Lo Russo ◽  
C. Paolella ◽  
...  
2016 ◽  
Vol 44 (5) ◽  
pp. 1244-1255 ◽  
Author(s):  
Yuankui Wu ◽  
Shruti Agarwal ◽  
Craig K. Jones ◽  
Andrew G. Webb ◽  
Peter C.M. van Zijl ◽  
...  

2015 ◽  
Vol 37 (5) ◽  
pp. 495-500 ◽  
Author(s):  
Umit Aksoy Ozcan ◽  
Ugur Isik ◽  
Alp Ozpinar ◽  
Nigar Baykan ◽  
Alp Dincer

2007 ◽  
Vol 311 (1) ◽  
pp. 460-463 ◽  
Author(s):  
Francisco José Lázaro ◽  
Lucía Gutiérrez ◽  
Ana Rosa Abadía ◽  
María Soledad Romero ◽  
Antonio López ◽  
...  

2014 ◽  
Vol 63 (12) ◽  
pp. S22
Author(s):  
Kenichi Manabe ◽  
Hiroshi Kamihata ◽  
Masayuki Motohiro ◽  
Takeshi Senoo ◽  
Susumu Yoshida ◽  
...  

2020 ◽  
Vol 30 (11) ◽  
pp. 6303-6310 ◽  
Author(s):  
Frédérique Dubrulle ◽  
Victor Chaton ◽  
Michael Risoud ◽  
Hedi Farah ◽  
Quentin Charley ◽  
...  
Keyword(s):  

2019 ◽  
Vol 24 (4) ◽  
pp. 166-173
Author(s):  
Giorgio Conte ◽  
Francesco Lo Russo ◽  
Luca Caschera ◽  
Diego Zanetti ◽  
Pierangela Castorina ◽  
...  

Objective: To describe clinical and imaging findings in a group of patients affected by nonsyndromic deafness A9 (DFNA9), using advanced magnetic resonance imaging (MRI) with 3-dimensional (3D) fluid-attenuated inversion recovery (FLAIR) sequence. Method: A retrospective case review was conducted in a tertiary referral center in Italy. Four sequential adult DFNA9-affected patients, who had undergone MRI at our Department between January 2017 and June 2018, were enrolled (male = 2, female = 2; median age: 65.6 years; 8 diseased ears analyzed). Three patients were relatives; the fourth was unrelated. The main outcome measures – age, sex, records of audiological and vestibular testing, genetic assessment, MRI findings – were analyzed. Results: All subjects suffered from bilateral progressive sensorineural hearing loss, more severely at the high frequencies and with a typical clinical pattern of bilateral chronic degenerative cochleovestibular deficit. Aural fullness was reported at the onset of the disease. All patients revealed a pathogenic heterozygous mutation in the Limulus factor C, Coch-5b2 and Lgl1 domain of cochlin. None of the patients showed a significant vestibular and cochlear endolymphatic hydrops at MRI, while high bilateral contrast enhancement on 4-h delayed postcontrast 3D FLAIR sequence was observed in all ears. Conclusions: Increased perilymph enhancement on 4-h delayed postcontrast 3D FLAIR sequence is the common imaging feature of DFNA9 ears, suggesting that blood-labyrinthine barrier breakdown may play the main role in the pathophysiology of this disease. Significant hydrops has been excluded by MRI. This finding might be clinically useful in differentiating DFNA9 disease from other pathologies with similar clinical findings like Ménière’s disease.


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