scholarly journals Measurement of arteriolar blood volume in brain tumors using MRI without exogenous contrast agent administration at 7T

2016 ◽  
Vol 44 (5) ◽  
pp. 1244-1255 ◽  
Author(s):  
Yuankui Wu ◽  
Shruti Agarwal ◽  
Craig K. Jones ◽  
Andrew G. Webb ◽  
Peter C.M. van Zijl ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Contrast Agent ◽  
Blood Volume ◽  
Contrast Agent Administration ◽  
Exogenous Contrast Agent

Early changes measured by magnetic resonance imaging in cerebral blood flow, blood volume, and blood-brain barrier permeability following dexamethasone treatment in patients with brain tumors

1999 ◽  
Vol 90 (2) ◽  
pp. 300-305 ◽  
Author(s):  
Leif Østergaard ◽  
Fred H. Hochberg ◽  
James D. Rabinov ◽  
A. Gregory Sorensen ◽  
Michael Lev ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Magnetic Resonance ◽  
Brain Tumors ◽  
Mr Imaging ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Clinical Effects ◽  
Content Type ◽  
Fine Print

Object. In this study the authors assessed the early changes in brain tumor physiology associated with glucocorticoid administration. Glucocorticoids have a dramatic effect on symptoms in patients with brain tumors over a time scale ranging from minutes to a few hours. Previous studies have indicated that glucocorticoids may act either by decreasing cerebral blood volume (CBV) or blood-tumor barrier (BTB) permeability and thereby the degree of vasogenic edema.Methods. Using magnetic resonance (MR) imaging, the authors examined the acute changes in CBV, cerebral blood flow (CBF), and BTB permeability to gadolinium-diethylenetriamine pentaacetic acid after administration of dexamethasone in six patients with brain tumors. In patients with acute decreases in BTB permeability after dexamethasone administration, changes in the degree of edema were assessed using the apparent diffusion coefficient of water.Conclusions. Dexamethasone was found to cause a dramatic decrease in BTB permeability and regional CBV but no significant changes in CBF or the degree of edema. The authors found that MR imaging provides a powerful tool for investigating the pathophysiological changes associated with the clinical effects of glucocorticoids.

Effect of Tumor Volume on Drug Delivery in Heterogeneous Vasculature of Human Brain Tumors

2019 ◽  
Vol 2 (2) ◽  
Author(s):  
Ajay Bhandari ◽  
Ankit Bansal ◽  
Rishav Jain ◽  
Anup Singh ◽  
Niraj Sinha
Keyword(s):  
Drug Delivery ◽  
Brain Tumors ◽  
Human Brain ◽  
Contrast Agent ◽  
Large Volume ◽  
Interstitial Fluid ◽  
Tumor Volume ◽  
Drug Distribution ◽  
Dce Mri ◽  
Concentration Of Contrast Agent

Drug distribution in tumors is strongly dependent on tumor biological properties such as tumor volume, vasculature, and porosity. An understanding of the drug distribution pattern in tumors can help in enhancing the effectiveness of anticancer treatment. A numerical model is employed to study the distribution of contrast agent in the heterogeneous vasculature of human brain tumors of different volumes. Dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) has been done for a number of patients with different tumor volumes. Leaky tracer kinetic model (LTKM) is employed to obtain perfusion parameters from the DCE-MRI data. These parameters are used as input in the computational fluid dynamics (CFD) model to predict interstitial fluid pressure (IFP), interstitial fluid velocity (IFV), and distribution of the contrast agent in different tumors. Numerical results demonstrate that the IFP is independent of tumor volume. On the other hand, the IFV increases as the tumor volume increases. Further, the concentration of contrast agent also increases with the tumor volume. The results obtained in this work are in line with the experimental DCE-MRI data. It is observed that large volume tumors tend to retain a higher concentration of contrast agent for a longer duration of time because of large extravasation flux and slow washout as compared to smaller tumors. These results may be qualitatively extrapolated to chemotherapeutic drug delivery, implying faster healing in large volume tumors. This study helps in understanding the effect of tumor volume on the treatment outcome for a wide range of human tumors.

scholarly journals Nanoparticle Contrast-enhanced T1-Mapping Enables Estimation of Placental Fractional Blood Volume in a Pregnant Mouse Model

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Andrew A. Badachhape ◽  
Laxman Devkota ◽  
Igor V. Stupin ◽  
Poonam Sarkar ◽  
Mayank Srivastava ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Blood Volume ◽  
Placental Tissue ◽  
Blood Pool ◽  
Pregnant Mouse ◽  
Gadolinium Contrast ◽  
Vascular Perfusion ◽  
Post Contrast ◽  
Placental Perfusion ◽  
Contrast Enhanced

AbstractNon-invasive methods for estimating placental fractional blood volume (FBV) are of great interest for characterization of vascular perfusion in placentae during pregnancy to identify placental insufficiency that may be indicative of local ischemia or fetal growth restriction (FGR). Nanoparticle contrast-enhanced magnetic resonance imaging (CE-MRI) may enable direct placental FBV estimation and may provide a reliable, 3D alternative to assess maternal-side placental perfusion. In this pre-clinical study, we investigated if placental FBV at 14, 16, and 18 days of gestation could be estimated through contrast-enhanced MRI using a long circulating blood-pool liposomal gadolinium contrast agent that does not penetrate the placental barrier. Placental FBV estimates of 0.47 ± 0.06 (E14.5), 0.50 ± 0.04 (E16.5), and 0.52 ± 0.04 (E18.5) were found through fitting pre-contrast and post-contrast T1 values in placental tissue using a variable flip angle method. MRI-derived placental FBV was validated against nanoparticle contrast-enhanced computed tomography (CE-CT) derived placental FBV, where signal is directly proportional to the concentration of iodine contrast agent. The results demonstrate successful estimation of the placental FBV, with values statistically indistinguishable from the CT derived values.

scholarly journals Measurement of absolute arterial cerebral blood volume in human brain without using a contrast agent

2011 ◽  
Vol 24 (10) ◽  
pp. 1313-1325 ◽  
Author(s):  
Jun Hua ◽  
Qin Qin ◽  
James J. Pekar ◽  
Peter C. M. van Zijl
Keyword(s):  
Human Brain ◽  
Contrast Agent ◽  
Blood Volume ◽  
Cerebral Blood Volume
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