scholarly journals Correlations between Perfusion MR Imaging Cerebral Blood Volume, Microvessel Quantification, and Clinical Outcome Using Stereotactic Analysis in Recurrent High-Grade Glioma

2011 ◽  
Vol 33 (1) ◽  
pp. 69-76 ◽  
Author(s):  
L.S. Hu ◽  
J.M. Eschbacher ◽  
A.C. Dueck ◽  
J.E. Heiserman ◽  
S. Liu ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Mr Imaging ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
High Grade Glioma ◽  
High Grade ◽  
Perfusion Mr ◽  
Perfusion Mr Imaging

scholarly journals Accuracy of tumor perfusion assessment in Rat C6 gliomas model with USPIO

Open Medicine ◽  
2019 ◽  
Vol 14 (1) ◽  
pp. 778-784
Author(s):  
Xiang-Rong Yu ◽  
Bo-Ling Cao ◽  
Wei Li ◽  
Ye Tian ◽  
Zhong-Li Du
Keyword(s):  
Mr Imaging ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Tumor Vasculature ◽  
C6 Glioma Cells ◽  
Mr Perfusion ◽  
Mean Values ◽  
Perfusion Mr ◽  
Perfusion Assessment ◽  
Perfusion Mr Imaging

AbstractDetailed characterization of the permeability and vascular volume of brain tumor vasculature can provide essential insights into tumor physiology. In this study, we evaluated the consistency of measurements in tumor blood volume and examined the feasibility of using ultrasmall superparamagnetic iron oxide (USPIO) versus gadolinium-diethylene triamine pentaacetic acid (Gd-DTPA) as contrast agents for MR perfusion imaging of brain gliomas in C6 Rats. Eighteen rats were intracerebrally implanted with C6 glioma cells, randomly divided into two groups and examined by 3.0T perfusion MR imaging with Gd-DTPA and USPIO. Tumor relative cerebral blood volume (rCBV) and relative maximum signal reduction ratio (rSRRmax) were created based on analysis of MR perfusion images. The mean values for rCBV were 2.09 and 1.57 in the USPIO and the Gd-DTPA groups, respectively, and rSRRmax values were 1.92 and 1.02 in the USPIO and the Gd-DTPA groups, respectively, showing signifi cant differences in both rCBV and rSRRmax between the USPIO and the Gd-DTPA groups (P < 0.05). The results showed that early vascular leakage occurred with gadolinium rather than USPIO in perfusion assessment, revealing that USPIO was useful in perfusion MR imaging for the assessment of tumor vasculature.

Is myocardial stress perfusion MR-imaging suitable to predict the long term clinical outcome after revascularization?

2013 ◽  
Vol 82 (10) ◽  
pp. 1776-1782 ◽  
Author(s):  
B. Klumpp ◽  
A. Seeger ◽  
C. Bretschneider ◽  
S. Mangold ◽  
P. Krumm ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Mr Imaging ◽  
Stress Perfusion ◽  
Myocardial Stress ◽  
Perfusion Mr ◽  
Perfusion Mr Imaging ◽  
Myocardial Stress Perfusion
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