scholarly journals Proton Density MRI Increases Detection of Cervical Spinal Cord Multiple Sclerosis Lesions Compared with T2-Weighted Fast Spin-Echo

2015 ◽  
Vol 37 (1) ◽  
pp. 180-184 ◽  
Author(s):  
A.L. Chong ◽  
R.V. Chandra ◽  
K.C. Chuah ◽  
E.L. Roberts ◽  
S.L. Stuckey
2019 ◽  
Vol 60 (4) ◽  
pp. 195-201
Author(s):  
Iman Emad Ahmed ◽  
Hayder Kareem Al-Jaberi ◽  
Mohammed M. Jawad Alkahlissi

Background: The prevalence of spinal cord lesions is high in multiple sclerosis particularly in the cervical cord, and their detection can assist in both the diagnosis and follow-up of the patients. For spinal multiple sclerosis, MRI is considered the first line investigation. Objective: To evaluate the value of sagittal 1.5 Tesla proton density-fast spin echo (PD-FSE) MRI in the detecting and increasing conspicuity of multiple sclerosis lesions in cervical cord in comparison with sagittal T2 fast spin-echo (T2-FSE) MRI. Patients and Methods: A cross sectional study carried out from 3rd of January 2017 to 1st of January 2018 in the MRI department of Al-Imamein Al-Kadhimein Medical City, and included 60 selected patients with a known diagnosis of multiple sclerosis. All patients were examined with 1.5 T sagittal PD-FSE, T2-FSE and axial gradient recalled-echo (GRE) MRI. Results: Sixty patients with cervical multiple sclerosis were enrolled in the study, 146 (100%) lesions were detected by PD-FSE imaging, while T2 detected 105 (71.9%), 41 more lesions (28%) were detected by PD-FSE imaging, (P-value <0.001). All extra lesions were confirmed on axial imaging. In 13 patients (21.6%) one lesion or more had been detected on sagittal PD-FSE imaging while on sagittal T2-FSE imaging, no lesion were detected. On PD-FSE imaging, 17 long lesions were detected in 16 patients (26.7%) while 7 long lesions in 7 patients (11.7%) were detected by T2-FSE imaging. So, in 9 patients (16.7%) 10 lesions were detected as long in PD-FSE while short lesion in T2– FSE, the detection of long lesions by PD-FSE was significantly higher than in T2– FSE (100% vs 71.9% with p- value of 0.002). The mean lesion contrast to cord ratio was significantly higher in PD-FSE as compared to T2-FSE (PD-FSE, 79±2.0, against T2-FSE, 61± 2.6; P-value <0.001). Conclusion: Sagittal proton density was more efficient and more accurate in the detection of cervical cord lesions than sagittal T2-FSE sequence, when used in conjunction with sagittal T2-FSE; it can raise the diagnostic assurance via improving the visualization of the lesions. 


2012 ◽  
Vol 199 (1) ◽  
pp. 157-162 ◽  
Author(s):  
Nancy Martin ◽  
David Malfair ◽  
Yinshan Zhao ◽  
David Li ◽  
Anthony Traboulsee ◽  
...  

Neurology ◽  
1993 ◽  
Vol 43 (12) ◽  
pp. 2632-2632 ◽  
Author(s):  
D. Kidd ◽  
J. W. Thorpe ◽  
A. J. Thompson ◽  
B. E. Kendall ◽  
I. F. Moseley ◽  
...  

1998 ◽  
Vol 40 (7) ◽  
pp. 416-419 ◽  
Author(s):  
V. L. Stevenson ◽  
I. F. Moseley ◽  
C. C. Phatouros ◽  
D. MacManus ◽  
A. J. Thompson ◽  
...  

1996 ◽  
Vol 61 (6) ◽  
pp. 632-635 ◽  
Author(s):  
M Filippi ◽  
T A Yousry ◽  
H Alkadhi ◽  
M Stehling ◽  
M A Horsfield ◽  
...  

1994 ◽  
Vol 12 (7) ◽  
pp. 983-989 ◽  
Author(s):  
J.W. Thorpe ◽  
D.G. MacManus ◽  
B.E. Kendall ◽  
P.S. Tofts ◽  
G.J. Barker ◽  
...  

2021 ◽  
pp. 197140092110177
Author(s):  
Chian A Chang ◽  
Abigail L Chong ◽  
Ronil V Chandra ◽  
Ernest Butler ◽  
Deepa Rajendran ◽  
...  

Background and purpose The magnetic resonance imaging in multiple sclerosis consensus guidelines currently mandate three sagittal non-contrast enhanced sequences of T2-weighted fast spin echo, proton density-weighted fast spin echo and short tau inversion recovery; however, these particular three sequences have not previously been compared at 3T. This study compared T2-weighted fast spin echo, proton density-weighted fast spin echo, short tau inversion recovery as well as the double inversion recovery sequence for the sagittal detection of multiple sclerosis lesions in the cervical spinal cord at 3T. Methods Nineteen multiple sclerosis patients underwent magnetic resonance imaging with 3T sagittal T2-weighted fast spin echo, proton density-weighted fast spin echo, short tau inversion recovery and double inversion recovery between November 2012 and April 2013. Two neuroradiologists independently reviewed the images, and the number of lesions detected on each sequence was recorded. Lesion conspicuity was quantitatively assessed with the lesion-to-cord-contrast ratio and lesion contrast-to-noise ratio. The Wilcoxon signed rank test was performed for statistical analysis. Results Proton density-weighted fast spin echo and short tau inversion recovery detected 32% more lesions compared to T2-weighted fast spin echo, and 37% more lesions compared to double inversion recovery. The lesion-to-cord-contrast ratio was highest in short tau inversion recovery, while the lesion contrast-to-noise ratio was highest for proton density-weighted fast spin echo. Conclusions This study provides the necessary evidentiary support at 3T for the magnetic resonance imaging in multiple sclerosis spinal magnetic resonance imaging protocol consensus guidelines. At 3T sagittal proton density-weighted fast spin echo and short tau inversion recovery sequences allowed improved detection of cervical spinal cord multiple sclerosis lesions, compared to T2-weighted fast spin echo and three-dimensional double inversion recovery magnetic resonance imaging. Utilising T2-weighted fast spin echo alone at 3T is insufficient for lesion detection.


1997 ◽  
Vol 244 (2) ◽  
pp. 119-124 ◽  
Author(s):  
Valerie L. Stevenson ◽  
Mary L. Gawne-Cain ◽  
Gareth J. Barker ◽  
Alan J. Thompson ◽  
D. H. Miller

2011 ◽  
Vol 35 (5) ◽  
pp. 653-661 ◽  
Author(s):  
Nabil J. Khoury ◽  
Ziyad Mahfoud ◽  
Karim Z. Masrouha ◽  
Rayan Elkattah ◽  
Toni Assaad ◽  
...  

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