scholarly journals Risk Factors for Hemorrhagic Complications following Pipeline Embolization Device Treatment of Intracranial Aneurysms: Results from the International Retrospective Study of the Pipeline Embolization Device

2015 ◽  
Vol 36 (12) ◽  
pp. 2308-2313 ◽  
Author(s):  
W. Brinjikji ◽  
G. Lanzino ◽  
H.J. Cloft ◽  
A.H. Siddiqui ◽  
D.F. Kallmes
Keyword(s):  
Risk Factors ◽  
Retrospective Study ◽  
Intracranial Aneurysms ◽  
Pipeline Embolization Device ◽  
Hemorrhagic Complications

scholarly journals Microhemorrhagic transformation of ischemic lesions on T2*-weighted magnetic resonance imaging after Pipeline embolization device treatment

2019 ◽  
Vol 130 (6) ◽  
pp. 1997-2004 ◽  
Author(s):  
Ryuta Nakae ◽  
Masaya Nagaishi ◽  
Yosuke Kawamura ◽  
Yoshihiro Tanaka ◽  
Akio Hyodo ◽  
...  
Keyword(s):  
Intracranial Aneurysms ◽  
Hemorrhagic Transformation ◽  
Diffusion Weighted Mri ◽  
Resonance Imaging ◽  
Mr Images ◽  
Pipeline Embolization Device ◽  
Hemorrhagic Complications ◽  
Weighted Magnetic Resonance Imaging ◽  
The Mean

OBJECTIVEThe authors sought to demonstrate that hemorrhagic transformation of ischemic lesions is the main cause of delayed intracerebral hemorrhage (ICH) after Pipeline embolization device (PED) treatment and to estimate the rate of hemorrhagic transformation of new postprocedure ischemic lesions.METHODSPatients who underwent PED placement (PED group) from November 2015 to March 2017 or stent-mediated embolization (EN group) from December 2010 to October 2015 were retrospectively analyzed. Pre- and postprocedural MR images and 6-month follow-up MR images for each patient were scored for the presence of postprocedural bland ischemic and hemorrhagic lesions using diffusion-weighted MRI (DWI) and T2*-weighted MRI (T2*WI), respectively.RESULTSThe PED group comprised 28 patients with 30 intracranial aneurysms, and the EN group comprised 24 patients with 27 intracranial aneurysms. The mean number of ischemic lesions on DWI 1 day postprocedure was higher in the PED group than in the EN group (5.2 vs 2.7, p = 0.0010). The mean number of microbleeds detected on T2*WI 6 months postprocedure was higher in the PED group than in the EN group (0.6 vs 0.15, p = 0.028). A total of 36.7% of PED-treated patients exhibited new microbleeds on T2*WI at 6 months postprocedure, with at least 77.8% of these lesions representing hemorrhagic transformations of the new ischemic lesions observed on day 1 postprocedure. The rate of adjunctive coil embolization (27.3% vs 0.0%, p = 0.016) and the mean number of ischemic lesions observed 1 day postprocedure (6.6 vs 4.3, p = 0.020) were predictors of subsequent microbleeds in the PED group.CONCLUSIONSNew microbleeds detected using T2*WI at 6 months postprocedure were more common after PED treatment than after stent-mediated embolization. Approximately three-quarters of these lesions were hemorrhagic transformations of new ischemic lesions observed on day 1 postprocedure. Prevention of intraprocedural or postprocedural infarcts is necessary to reduce the risk of hemorrhagic complications following PED placement.

scholarly journals Occlusive Cerebrovascular Disease in Young Adults

1984 ◽  
Vol 11 (2) ◽  
pp. 302-304 ◽  
Author(s):  
Gary M. Klein ◽  
T. Peter Seland
Keyword(s):  
Risk Factors ◽  
Young Adults ◽  
Retrospective Study ◽  
Cerebrovascular Disease ◽  
Oral Contraceptives ◽  
Intracranial Aneurysms ◽  
Chart Review ◽  
Teaching Hospitals ◽  
Complicated Migraine

ABSTRACT:This retrospective study documents the experience of two large Canadian teaching hospitals with occlusive cerebrovascular disease in young adults. Chart review disclosed 76 patients aged 15-40 years during a recent six year period. An apparent cause, or significant coincident risk factors were found in 51 patients (67%). The most prevalent recognized causes were atherosclerosis, emboli from cardiac sources or intracranial aneurysms, and complicated migraine. Pregnancies or use of oral contraceptives were apparent coincident risk factors.

scholarly journals Safety and efficacy of the Pipeline embolization device for treatment of intracranial aneurysms: a pooled analysis of 3 large studies

2017 ◽  
Vol 127 (4) ◽  
pp. 775-780 ◽  
Author(s):  
David F. Kallmes ◽  
Waleed Brinjikji ◽  
Saruhan Cekirge ◽  
David Fiorella ◽  
Ricardo A. Hanel ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Retrospective Study ◽  
Mortality Rate ◽  
Intracranial Hemorrhage ◽  
Intracranial Aneurysms ◽  
Pooled Analysis ◽  
Pipeline Embolization Device ◽  
Neurological Morbidity ◽  
The Mean

OBJECTIVEThe authors performed a pooled analysis of 3 studies—IntrePED (International Retrospective Study of the Pipeline Embolization Device), PUFS (Pipeline for Uncoilable or Failed Aneurysms Study), and ASPIRe (Aneurysm Study of Pipeline in an Observational Registry)—in order to assess angiographic outcomes and clinical safety of the Pipeline embolization device (PED).METHODSIntrePED was a retrospective study, while PUFS and ASPIRe were prospective studies. For each patient included in these studies, the authors collected baseline demographic data, aneurysm characteristics, and procedural details. The primary outcomes for this combined analysis were clinical outcomes, including neurological morbidity and mortality and major ipsilateral intracranial hemorrhage and ischemic stroke. The secondary outcomes were angiographic occlusion rates, which were available for ASPIRe and PUFS only.RESULTSA total of 1092 patients with 1221 aneurysms were included across the 3 studies. The mean aneurysm size was 12.0 ± 7.8 mm and the mean neck size was 6.6 ± 4.8 mm. The major ipsilateral ischemic stroke rate was 3.7% (40/1091). The major ipsilateral intracranial hemorrhage rate was 2.0% (22/1091). The major neurological morbidity rate was 5.7% (62/1091). The neurological mortality rate was 3.3% (36/1091). The combined major morbidity and neurological mortality rate was 7.1% (78/1091). The complete occlusion rates were 75.0% at 180 days (111/148) and 85.5% at 1 year (94/110). The overall aneurysm retreatment rate was 3.0% (33/1091) at a mean follow-up time of 10.2 ± 10.8 months.CONCLUSIONSEndovascular treatment of intracranial aneurysms with the PED is safe and effective. Angiographic occlusion rates progressed with follow-up. Rates of stroke, hemorrhage, morbidity and mortality, and retreatment were low, especially given the fact that the aneurysms treated were generally large and wide necked.

Risk factors for multiple intracranial aneurysms rupture: A retrospective study

2013 ◽  
Vol 115 (6) ◽  
pp. 690-694 ◽  
Author(s):  
Hai-Tao Lu ◽  
Hua-Qiao Tan ◽  
Bin-Xian Gu ◽  
Wu-Wang ◽  
Ming-Hua Li
Keyword(s):  
Risk Factors ◽  
Retrospective Study ◽  
Intracranial Aneurysms ◽  
Multiple Intracranial Aneurysms
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