scholarly journals Thrombotic and hemorrhagic complications during visceral transplantation: risk factors, and association with intraoperative disseminated intravascular coagulation-like thromboelastographic qualities: a single-center retrospective study

2018 ◽  
Vol 31 (10) ◽  
pp. 1125-1134 ◽  
Author(s):  
Yehuda Raveh ◽  
Yiliam Rodriguez ◽  
Ernesto Pretto ◽  
Fouad Souki ◽  
Vadim Shatz ◽  
...  
Keyword(s):  
Risk Factors ◽  
Retrospective Study ◽  
Disseminated Intravascular Coagulation ◽  
Single Center ◽  
Intravascular Coagulation ◽  
Hemorrhagic Complications

Serum procalcitonin levels predict disseminated intravascular coagulation in patients with sepsis shock: A retrospective cohort study

2020 ◽  
Author(s):  
Guang Fu ◽  
Xi-si He ◽  
Hao-li Li ◽  
Hai-chao Zhan ◽  
Jun-fu Lu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Septic Shock ◽  
Cohort Study ◽  
Disseminated Intravascular Coagulation ◽  
Area Under The Curve ◽  
Multivariable Logistic Regression Model ◽  
Intravascular Coagulation ◽  
The Relationship ◽  
Conventional Risk Factors

Abstract Background Complication of disseminated intravascular coagulation (DIC) is a determinant of the prognosis in patients with sepsis shock. Procalcitonin (PCT) has been advocated as a marker of bacterial sepsis. The purpose of this study was to evaluate the relationship between serum PCT levels and DIC with sepsis shock Methods A cohort study was designed which included patients that admitted in intensive care unit (ICU) between January 1, 2015 and December 31, 2018 and the follow-up to discharge. 164 septic shock patients were divided into DIC and non-DIC groups according to international society of thrombosis and homeostasis (ISTH). PCT was measured at the admission to ICU, and all the participants received routine biochemical coagulation test subsequently. Results PCT levels were considerably higher in septic shock patients who developed DIC than those who did not (54.6[13.6–200]vs12.6[2.4–53.3]ng/ml), respectively, P < 0.001). Multivariable logistic regression model revealed that PCT level was significantly associated with risk of DIC independent of conventional risk factors. In addition, curve fitting showed a linear relationship between PCT and DIC score. The Receiver Operating characteristic(ROC) curve suggested that the optimal cut-off point for PCT to predicting DIC induced by septic shock was 42.0 ng/ml, and the area under the curve (AUC) was 0.701(95% CI [0.619–0.784], P < 0.001). More importantly, incorporating PCT with other risk factors into the prediction model significantly increased the AUC for prediction of DIC induced by sepsis shock (0.801vs 0.706; P = 0.012). Conclusions Our study suggests that PCT levels on admission is significantly and independently associated with DIC development subsequently with septic shock, combining PCT levels with other risk factors could significantly improve the prediction of DIC induced by sepsis shock.

scholarly journals Central pontine myelinolysis during treatment of hyperglycemic hyperosmolar syndrome: a case report

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Koshi Kusumoto ◽  
Nobuyuki Koriyama ◽  
Nami Kojima ◽  
Maki Ikeda ◽  
Yoshihiko Nishio
Keyword(s):  
Risk Factors ◽  
Disseminated Intravascular Coagulation ◽  
Thrombus Formation ◽  
Central Pontine Myelinolysis ◽  
Bed Rest ◽  
Severe Illness ◽  
Intravascular Coagulation ◽  
Disturbance Of Consciousness ◽  
Pontine Myelinolysis ◽  
Central Pontine

Abstract Background Central pontine myelinolysis (CPM) is a non-inflammatory demyelinating lesion of the pons. CPM and extrapontine demyelination (EPM) are together termed osmotic demyelination syndrome (ODS), a known and serious complication of acute correction of hyponatremia. Conversely, hyperglycemic hyperosmolarity syndrome (HHS) develops in patients with type 2 diabetes who still have some insulin secretory ability due to infection, non-compliance with treatment, drugs, and coexisting diseases, and is often accompanied by ketosis. HHS represents a life-threatening endocrine emergency (mortality rate, 10–50%) associated with marked hyperglycemia and severe dehydration. HHS may develop ODS, and some cases have been associated with hypernatremia. Case presentation The patient was an 87-year-old woman with hyperglycemia, dehydration, malnutrition, and potential thrombus formation during long-term bed rest. HHS was suspected to have developed due to progression of hyperglycemia and dehydration caused by pneumonia. Furthermore, ketoacidosis developed from ketosis and prerenal renal failure associated with circulating hypovolemia shock, which was also associated with disseminated intravascular coagulation. Treatment was started with continuous intravenous injection of fast-acting insulin and low-sodium replacement fluid. In addition, ceftriaxone sodium hydrate, heparin sodium, thrombomodulin α, human serum albumin, and dopamine hydrochloride were administered. Blood glucose, serum sodium, serum osmolality, and general condition (including vital, infection/inflammatory findings, and disseminated intravascular coagulation) improved promptly, but improvements in disturbance of consciousness were poor. Diffusion-weighted imaging of the brain 72 h after starting treatment showed no obvious abnormalities, but high-intensity signals in the midline of the pons became apparent 30 days later, leading to definitive diagnosis of CPM. Conclusions Fluctuation of osmotic pressure by treatment from hyperosmolarity due to hyperglycemia and hypernatremia in the presence of risk factors such as malnutrition, severe illness, and metabolic disorders may be a cause of CPM onset. When treating HHS with risk factors, the possibility of progression to ODS needs to be kept in mind.

scholarly journals Epidemiology and risk factors for mortality in bloodstream infections: A single-center retrospective study in Japan

2018 ◽  
Vol 46 (12) ◽  
pp. e75-e79 ◽  
Author(s):  
Haruka Hattori ◽  
Masayuki Maeda ◽  
Yasuhiro Nagatomo ◽  
Takahiro Takuma ◽  
Yoshihito Niki ◽  
...  
Keyword(s):  
Risk Factors ◽  
Retrospective Study ◽  
Bloodstream Infections ◽  
Single Center

The Leiden Mutation and Activated Protein C Resistance as Risk Factors for Disseminated Intravascular Coagulation in Acutely Poisoned Patients

2006 ◽  
Vol 44 (1) ◽  
pp. 53-57
Author(s):  
Mirosław Prazanowski ◽  
Barbara Kur ◽  
Małgorzata Barańska ◽  
Waldemar Lutz ◽  
Bożena Piłacik ◽  
...  
Keyword(s):  
Risk Factors ◽  
Disseminated Intravascular Coagulation ◽  
Protein C ◽  
Activated Protein C ◽  
Activated Protein C Resistance ◽  
Intravascular Coagulation

scholarly journals Risk factors for post-ERCP cholecystitis: a single-center retrospective study

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Jun Cao ◽  
Chunyan Peng ◽  
Xiwei Ding ◽  
Yonghua Shen ◽  
Han Wu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Retrospective Study ◽  
Single Center
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