scholarly journals No Evidence for Impairment of Venous Hemodynamics in Children or Young Adults with Pediatric-Onset Multiple Sclerosis

2013 ◽  
Vol 34 (12) ◽  
pp. 2366-2372 ◽  
Author(s):  
S. Laughlin ◽  
C.K. Macgowan ◽  
J. Traubici ◽  
K. Chan ◽  
S. Khan ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Young Adults ◽  
Pediatric Onset

scholarly journals 7T MRI Visualization of Cortical Lesions in Adolescents and Young Adults with Pediatric-Onset Multiple Sclerosis

2017 ◽  
Vol 27 (5) ◽  
pp. 447-452 ◽  
Author(s):  
Ritobrato Datta ◽  
Varun Sethi ◽  
Sophia Ly ◽  
Amy T. Waldman ◽  
Sona Narula ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Young Adults ◽  
Adolescents And Young Adults ◽  
Cortical Lesions ◽  
Pediatric Onset

Examining cognitive speed and accuracy dysfunction in youth and young adults with pediatric-onset multiple sclerosis using a computerized neurocognitive battery.

2021 ◽  
Vol 35 (4) ◽  
pp. 388-398
Author(s):  
Emily Barlow-Krelina ◽  
Tracy L. Fabri ◽  
Julia O'Mahony ◽  
Ruben C. Gur ◽  
Raquel E. Gur ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Young Adults ◽  
Youth And Young Adults ◽  
Cognitive Speed ◽  
Speed And Accuracy ◽  
Pediatric Onset

scholarly journals Quality of Life, Cognition and Mood in Adults with Pediatric Multiple Sclerosis

2016 ◽  
Vol 43 (3) ◽  
pp. 368-374 ◽  
Author(s):  
Kristen M. Krysko ◽  
Paul O’Connor
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Young Adults ◽  
Cognitive Function ◽  
Physical Disability ◽  
Normative Data ◽  
Short Form ◽  
Physical Hrqol ◽  
Pediatric Onset

AbstractBackground: Pediatric onset multiple sclerosis (MS) negatively affects cognitive function, mood and health related quality of life (HRQOL). We aimed to explore the cognitive, psychological and HRQOL impacts of pediatric MS on young adults and to explore the relationships between disability, disease duration, cognition, mood and HRQOL in this hypotheses generating study. Methods: Thirty-four young adults with pediatric onset MS at St. Michael’s Hospital in Toronto were included in this cross-sectional study (mean age 21.3 years, 56% female). Participants completed assessments of physical disability (Expanded Disability Status Scale (EDSS)), cognitive function (Symbol Digit Modalities Test (SDMT)), mood (Beck Depression Inventory II (BDI-II)), and HRQOL (Short Form Health Survey (SF-36v2)). Findings were compared to age- and gender- matched normative data. Results: Individuals with pediatric MS performed worse on the SDMT compared to normative data, with 53% demonstrating cognitive impairment. There was no difference in BDI-II scores from normative data, but 21% showed at least mild depression. There was a non-significant impairment in physical HRQOL compared to normative data. Decreased physical HRQOL was related to disability (EDSS), while mental HRQOL was related to depression (BDI-II). Conclusions: Young adults with pediatric MS have reduced cognitive function. Non-significant reductions in HRQOL may be partly attributed to physical disability and depression. These factors should be addressed in the care of adults with pediatric MS. Further studies including control groups and longitudinal design are needed to confirm these findings.

Upper Extremity Motor Fatigability as an Early Indicator in Pediatric Onset Multiple Sclerosis

2021 ◽  
pp. 088307382199988
Author(s):  
Giuseppina Pilloni ◽  
Martin Malik ◽  
Raghav Malik ◽  
Lauren Krupp ◽  
Leigh Charvet
Keyword(s):  
Multiple Sclerosis ◽  
Grip Strength ◽  
Upper Extremity ◽  
Static Fatigue ◽  
Healthy Controls ◽  
Fatigue Index ◽  
Left Hand ◽  
Right Hand ◽  
Computer Based ◽  
Pediatric Onset

Aim: To adopt a computer-based protocol to assess grip fatigability in patients with pediatric-onset multiple sclerosis to provide detection of subtle motor involvement identifying those patients most at risk for future decline. Method: Pediatric-onset multiple sclerosis patients were recruited during routine outpatient visits to complete a grip assessment and compared to a group of healthy age- and sex-matched controls. All participants completed a computer-based measurement of standard maximal grip strength and repetitive and sustained grip performance measured by dynamic and static fatigue indices. Results: A total of 38 patients with pediatric-onset multiple sclerosis and 24 healthy controls completed the grip protocol (right-hand dominant). There were no significant group differences in maximal grip strength bilaterally (right: 21.8 vs 19.9 kg, P = .25; left: 20.4 vs 18.7 kg, P = .33), although males with pediatric-onset multiple sclerosis were significantly less strong than healthy controls (right: 26.53 vs 21.23 kg, P = .009; left; 25.13 vs 19.63 kg, P = .003). Both dynamic and static fatigue indices were significantly higher bilaterally in pediatric-onset multiple sclerosis compared with healthy control participants (left-hand dynamic fatigue index: 18.6% vs 26.7%, P = .003; right-hand static fatigue index: 28.3% vs 41.3%, P < .001; left-hand static fatigue index: 31.9% vs 42.6%, P < .001). Conclusion: Brief repeatable grip assessment including measures of dynamic and sustained static output can be a sensitive indicator of upper extremity motor involvement in pediatric-onset multiple sclerosis, potentially identifying those in need of intervention to prevent future disability.

scholarly journals Memory, Processing of Emotional Stimuli, and Volume of Limbic Structures in Pediatric-Onset Multiple Sclerosis

2021 ◽  
pp. 102753
Author(s):  
Tracy L Fabri ◽  
Ritobrato Datta ◽  
Julia O'Mahony ◽  
Emily Barlow-Krelina ◽  
Elisea De Somma ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Emotional Stimuli ◽  
Limbic Structures ◽  
Memory Processing ◽  
Pediatric Onset
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