scholarly journals Assessing Abnormal Iron Content in the Deep Gray Matter of Patients with Multiple Sclerosis versus Healthy Controls

2011 ◽  
Vol 33 (2) ◽  
pp. 252-258 ◽  
Author(s):  
C.A. Habib ◽  
M. Liu ◽  
N. Bawany ◽  
J. Garbern ◽  
I. Krumbein ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Gray Matter ◽  
Iron Content ◽  
Healthy Controls ◽  
Deep Gray Matter

Iron content of the pulvinar nucleus of the thalamus is increased in adolescent multiple sclerosis

2012 ◽  
Vol 19 (5) ◽  
pp. 567-576 ◽  
Author(s):  
Jesper Hagemeier ◽  
E Ann Yeh ◽  
Mari Heininen Brown ◽  
Niels Bergsland ◽  
Michael G Dwyer ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Gray Matter ◽  
Iron Content ◽  
Neurological Disorders ◽  
Normal Phase ◽  
Susceptibility Weighted Imaging ◽  
Healthy Controls ◽  
Volume Measurements ◽  
Deep Gray Matter ◽  
Age And Sex

Objective: The objective of this paper is to assess abnormal phase values, indicative of increased iron content, using susceptibility-weighted imaging (SWI)-filtered phase of the subcortical deep gray matter (SDGM) in adolescent multiple sclerosis (MS) and other neurological disorders (OND) patients, and in healthy controls (HC). Methods: Twenty adolescent MS and eight adolescent OND patients and 21 age- and sex-matched HC were scanned on a 3T GE scanner. Mean phase of abnormal phase tissue (MP-APT), MP-APT volume, normal phase tissue volume (NPTV) and normalized volume measurements were obtained for total SDGM, as well as specific structures separately. Results: Significantly increased MP-APT (28.2%, p<.001) and MP-APT volume (82.7%, p<.001), and decreased NPTV (−23.3%, p<.001) and normalized volume (−15.5%, p<.001) in the pulvinar nucleus of the thalamus was found in MS patients compared to HC. MP-APT in MS patients was also increased in total SDGM ( p=.012) and thalamus ( p=.044). Compared to OND patients, MS patients had increased MP-APT volume in the pulvinar nucleus of the thalamus ( p=.044) and caudate ( p=.045). Increased MP-APT of the SDGM structures were associated with increased T2 and T1 lesion burden and brain atrophy in MS patients. Conclusion: Adolescent MS patients showed increased iron content in the SDGM compared to OND patients and HC.

scholarly journals Deep Gray Matter Iron Content in Neuromyelitis Optica and Multiple Sclerosis

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Adam Pudlac ◽  
Andrea Burgetova ◽  
Petr Dusek ◽  
Petra Nytrova ◽  
Manuela Vaneckova ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Magnetic Susceptibility ◽  
Substantia Nigra ◽  
Neuromyelitis Optica ◽  
Gray Matter ◽  
Iron Homeostasis ◽  
Iron Concentration ◽  
Clinical Severity ◽  
Healthy Controls ◽  
Deep Gray Matter

Background. Neuromyelitis optica (NMO) and multiple sclerosis (MS) are often presenting with overlapping symptoms. The aim of this study was to determine whether and how NMO and MS differ regarding cerebral iron deposits in deep gray matter (DGM) and the correlation between iron deposition and clinical severity as well as to regional atrophy of the DGM. Methods. We analyzed 20 patients with NMO, 40 patients with a relapsing-remitting (RR) form of MS, and 20 healthy controls with 1.5T MRI. Quantitative susceptibility mapping (QSM) was performed to estimate iron concentration in the DGM. Results. Patients with NMO have higher magnetic susceptibility values in the substantia nigra compared to healthy controls. RRMS patients have lower magnetic susceptibility values in the thalamus compared to healthy controls and NMO patients. Atrophy of the thalamus, pulvinar, and putamen is significant both in RRMS compared to NMO patients and healthy controls. A correlation was found between the disability score (EDSS) and magnetic susceptibility in the putamen in RRMS. Conclusions. This study confirms that a disturbed cerebral iron homeostasis in patients with NMO occurs in different structures than in patients with RRMS. Increased magnetic susceptibility in substantia nigra in NMO and decreased magnetic susceptibility within the thalamus in RRMS were the only significant differences in the study sample. We could confirm that iron concentration in the thalami is decreased in RRMS compared to that in the HC group. Positive association was found between putaminal iron and EDSS in RRMS.

Detection of Cortical and Deep Gray Matter Lesions in Multiple Sclerosis Using DIR and FLAIR at 3T

2020 ◽  
Author(s):  
Charlie C. Park ◽  
Dean W. Thongkham ◽  
Gelareh Sadigh ◽  
Amit M. Saindane ◽  
Renxin Chu ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Gray Matter ◽  
Deep Gray Matter

Association of Age at Onset With Gray Matter Volume and White Matter Microstructural Abnormalities in People With Multiple Sclerosis

Neurology ◽  
2021 ◽  
pp. 10.1212/WNL.0000000000012869
Author(s):  
Raffaello Bonacchi ◽  
Alessandro Meani ◽  
Elisabetta Pagani ◽  
Olga Marchesi ◽  
Andrea Falini ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Gray Matter ◽  
Linear Models ◽  
Gray Matter Volume ◽  
Age At Onset ◽  
Healthy Controls ◽  
Compensatory Mechanisms ◽  
Cross Sectional ◽  
Matter Volume

Objective:To investigate whether age at onset influences brain gray matter volume (GMV) and white matter (WM) microstructural abnormalities in adult multiple sclerosis (MS) patients, given its influence on clinical phenotype and disease course.Method:In this hypothesis-driven cross-sectional study, we enrolled 67 pediatric-onset MS (POMS) patients and 143 sex- and disease duration (DD)-matched randomly-selected adult-onset MS (AOMS) patients, together with 208 healthy controls. All subjects underwent neurological evaluation and 3T MRI acquisition. MRI variables were standardized based on healthy controls, to remove effects of age and sex. Associations with DD in POMS and AOMS patients were studied with linear models. Time to reach clinical and MRI milestones was assessed with product-limit approach.Results:At DD=1 year, GMV and WM fractional anisotropy (FA) were abnormal in AOMS but not in POMS patients. Significant interaction of age at onset (POMS vs AOMS) into the association with DD was found for GMV and WM FA. The crossing point of regression lines in POMS and AOMS patients was at 20 years of DD for GMV and 14 for WM FA. For POMS and AOMS patients, median DD was 29 and 19 years to reach Expanded Disability Status Scale=3 (p<0.001), 31 and 26 years to reach abnormal Paced Auditory Serial Addition Task-3 (p=0.01), 24 and 18 years to reach abnormal GMV (p=0.04), and 19 and 17 years to reach abnormal WM FA (p=0.36).Conclusions:Younger patients are initially resilient to MS-related damage. Then, compensatory mechanisms start failing with loss of WM integrity, followed by GM atrophy and finally disability.

scholarly journals Cerebral Arterial Bolus Arrival Time is Prolonged in Multiple Sclerosis and Associated with Disability

2013 ◽  
Vol 34 (1) ◽  
pp. 34-42 ◽  
Author(s):  
David Paling ◽  
Esben Thade Petersen ◽  
Daniel J Tozer ◽  
Daniel R Altmann ◽  
Claudia AM Wheeler-Kingshott ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Gray Matter ◽  
Arrival Time ◽  
Arterial Hemodynamics ◽  
Normal Appearing White Matter ◽  
Imaging Sequence ◽  
Disability Status ◽  
Relapsing Remitting ◽  
Bolus Arrival Time ◽  
Deep Gray Matter

Alterations in the overall cerebral hemodynamics have been reported in multiple sclerosis (MS); however, their cause and significance is unknown. While potential venous causes have been examined, arterial causes have not. In this study, a multiple delay time arterial spin labeling magnetic resonance imaging sequence at 3T was used to quantify the arterial hemodynamic parameter bolus arrival time (BAT) and cerebral blood flow (CBF) in normal-appearing white matter (NAWM) and deep gray matter in 33 controls and 35 patients with relapsing–remitting MS. Bolus arrival time was prolonged in MS in NAWM (1.0±0.2 versus 0.9±0.2 seconds, P=0.031) and deep gray matter (0.90±0.18 versus 0.80±0.14 seconds, P=0.001) and CBF was increased in NAWM (14±4 versus 10±2 mL/100 g/min, P=0.001). Prolonged BAT in NAWM ( P=0.042) and deep gray matter ( P=0.01) were associated with higher expanded disability status score. This study demonstrates alteration in cerebral arterial hemodynamics in MS. One possible cause may be widespread inflammation. Bolus arrival time was longer in patients with greater disability independent of atrophy and T2 lesion load, suggesting alterations in cerebral arterial hemodynamics may be a marker of clinically relevant pathology.

scholarly journals Whole brain and deep gray matter atrophy detection over 5 years with 3T MRI in multiple sclerosis using a variety of automated segmentation pipelines

PLoS ONE ◽  
2018 ◽  
Vol 13 (11) ◽  
pp. e0206939 ◽  
Author(s):  
Renxin Chu ◽  
Gloria Kim ◽  
Shahamat Tauhid ◽  
Fariha Khalid ◽  
Brian C. Healy ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Gray Matter ◽  
Automated Segmentation ◽  
Whole Brain ◽  
3T Mri ◽  
Gray Matter Atrophy ◽  
Deep Gray Matter

scholarly journals Determinants of Deep Gray Matter Atrophy in Multiple Sclerosis: A Multimodal MRI Study

2018 ◽  
Vol 40 (1) ◽  
pp. 99-106 ◽  
Author(s):  
G. Pontillo ◽  
S. Cocozza ◽  
R. Lanzillo ◽  
C. Russo ◽  
M.D. Stasi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Gray Matter ◽  
Gray Matter Atrophy ◽  
Multimodal Mri ◽  
Deep Gray Matter ◽  
Mri Study
Sign in / Sign up

Export Citation Format

Share Document