Detection of Cortical and Deep Gray Matter Lesions in Multiple Sclerosis Using DIR and FLAIR at 3T

2020 ◽  
Author(s):  
Charlie C. Park ◽  
Dean W. Thongkham ◽  
Gelareh Sadigh ◽  
Amit M. Saindane ◽  
Renxin Chu ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Gray Matter ◽  
Deep Gray Matter

scholarly journals Cerebral Arterial Bolus Arrival Time is Prolonged in Multiple Sclerosis and Associated with Disability

2013 ◽  
Vol 34 (1) ◽  
pp. 34-42 ◽  
Author(s):  
David Paling ◽  
Esben Thade Petersen ◽  
Daniel J Tozer ◽  
Daniel R Altmann ◽  
Claudia AM Wheeler-Kingshott ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Gray Matter ◽  
Arrival Time ◽  
Arterial Hemodynamics ◽  
Normal Appearing White Matter ◽  
Imaging Sequence ◽  
Disability Status ◽  
Relapsing Remitting ◽  
Bolus Arrival Time ◽  
Deep Gray Matter

Alterations in the overall cerebral hemodynamics have been reported in multiple sclerosis (MS); however, their cause and significance is unknown. While potential venous causes have been examined, arterial causes have not. In this study, a multiple delay time arterial spin labeling magnetic resonance imaging sequence at 3T was used to quantify the arterial hemodynamic parameter bolus arrival time (BAT) and cerebral blood flow (CBF) in normal-appearing white matter (NAWM) and deep gray matter in 33 controls and 35 patients with relapsing–remitting MS. Bolus arrival time was prolonged in MS in NAWM (1.0±0.2 versus 0.9±0.2 seconds, P=0.031) and deep gray matter (0.90±0.18 versus 0.80±0.14 seconds, P=0.001) and CBF was increased in NAWM (14±4 versus 10±2 mL/100 g/min, P=0.001). Prolonged BAT in NAWM ( P=0.042) and deep gray matter ( P=0.01) were associated with higher expanded disability status score. This study demonstrates alteration in cerebral arterial hemodynamics in MS. One possible cause may be widespread inflammation. Bolus arrival time was longer in patients with greater disability independent of atrophy and T2 lesion load, suggesting alterations in cerebral arterial hemodynamics may be a marker of clinically relevant pathology.

scholarly journals Whole brain and deep gray matter atrophy detection over 5 years with 3T MRI in multiple sclerosis using a variety of automated segmentation pipelines

PLoS ONE ◽  
2018 ◽  
Vol 13 (11) ◽  
pp. e0206939 ◽  
Author(s):  
Renxin Chu ◽  
Gloria Kim ◽  
Shahamat Tauhid ◽  
Fariha Khalid ◽  
Brian C. Healy ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Gray Matter ◽  
Automated Segmentation ◽  
Whole Brain ◽  
3T Mri ◽  
Gray Matter Atrophy ◽  
Deep Gray Matter

scholarly journals Determinants of Deep Gray Matter Atrophy in Multiple Sclerosis: A Multimodal MRI Study

2018 ◽  
Vol 40 (1) ◽  
pp. 99-106 ◽  
Author(s):  
G. Pontillo ◽  
S. Cocozza ◽  
R. Lanzillo ◽  
C. Russo ◽  
M.D. Stasi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Gray Matter ◽  
Gray Matter Atrophy ◽  
Multimodal Mri ◽  
Deep Gray Matter ◽  
Mri Study

Unraveling Deep Gray Matter Atrophy and Iron and Myelin Changes in Multiple Sclerosis

2021 ◽  
Author(s):  
G. Pontillo ◽  
M. Petracca ◽  
S. Monti ◽  
M. Quarantelli ◽  
C. Criscuolo ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Gray Matter ◽  
Gray Matter Atrophy ◽  
Deep Gray Matter

scholarly journals What Causes Deep Gray Matter Atrophy in Multiple Sclerosis?

2018 ◽  
Vol 40 (1) ◽  
pp. 107-108 ◽  
Author(s):  
M.M. Schoonheim ◽  
J.J.G. Geurts
Keyword(s):  
Multiple Sclerosis ◽  
Gray Matter ◽  
Gray Matter Atrophy ◽  
Deep Gray Matter

The Impact of MRI T1 Hypointense Brain Lesions on Cerebral Deep Gray Matter Volume Measures in Multiple Sclerosis

2019 ◽  
Author(s):  
Korhan Buyukturkoglu ◽  
Enricomaria Mormina ◽  
Philip L. Jager ◽  
Claire S. Riley ◽  
Victoria M. Leavitt
Keyword(s):  
Multiple Sclerosis ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Brain Lesions ◽  
Matter Volume ◽  
Deep Gray Matter ◽  
The Impact
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