scholarly journals Burden of Alcoholic Liver Disease in a Tertiary Care Center: A Descriptive Cross-sectional Study

2019 ◽  
Vol 57 (219) ◽  
Author(s):  
Shikha Rizal ◽  
Bishal Raj Joshi ◽  
Arambam Giridhari Singh
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Alcoholic Liver Disease ◽  
Fatty Liver Disease ◽  
Care Center ◽  
Tertiary Care ◽  
Tertiary Care Center ◽  
Cross Sectional ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Introduction: Alcoholic liver disease is a serious health problem related to an unhealthy lifestyle. The three most widely recognized forms of alcoholic liver disease are alcoholic fatty liver, acute alcoholic hepatitis, and alcoholic cirrhosis. The main aim of our study is to find out the prevalence of alcoholic liver disease in tertiary care center. Methods: A descriptive cross-sectional study was conducted among inpatient cases admitted in the medicine department of tertiary care center from 1st June 2018 to 31st May 2019. Ethical approval was taken for the study. Convenience sampling method was used. All the biochemical parameters were expressed as mean±standard deviation for each group and point estimate at 95% Confidence Interval was calculated along with frequency and proportion for binary data. Results: Prevalence of alcoholic liver disease is 50 (50%) at a 95% Confidence Interval (40.2%-59.8%) and non-alcoholic fatty liver disease is also the same. The mean age of alcoholic liver disease was 59±12 years where as the mean age for non-alcoholic fatty liver disease was 46±18 years. Out of fifty patients of alcoholic liver disease, majority 48 (96%) of the cases were males which suggests that the prevalence of alcoholic liver disease is very common in males. Similarly, for non-alcoholic fatty liver disease, prevalence was 34 (68%) showing higher prevalence than that of females. Conclusions: Prevalence of alcoholic liver disease is low compared to previous studies done in the similar settings. Monitoring these biochemical parameters in alcoholic liver disease at early stage could guide in planning the protocol for the initial treatment.

scholarly journals Nonalcoholic Fatty Liver Disease and Metabolic Syndrome among patients attending in a tertiary care center in Bangladesh

2018 ◽  
Vol 28 (2) ◽  
pp. 44-51
Author(s):  
MMR Khan ◽  
MK Rahman ◽  
NK Sana ◽  
PM Basak ◽  
BC Sarker ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Liver Disease ◽  
Fatty Liver ◽  
Chronic Liver Disease ◽  
Fatty Liver Disease ◽  
Care Center ◽  
Tertiary Care ◽  
Tertiary Care Center ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease (NAFLD) is an emerging chronic liver disease and may lead to liver cirrhosis and hepatocellular carcinoma. It is now the most common chronic liver disease in many developed as well as developing countries. This hospital based study was done to see the prevalence of non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome among patients attending in a tertiary care center in Bangladesh. Here, 334 nonalcoholic subjects of both sex and age were included. Metabolic syndrome was assessed by modified ATP III criteria and fatty liver diagnosis was based on ultrasound findings. 27.2% had the metabolic syndrome and was more common in female. Prevalence of NAFLD was 44% and was more common in female. Metabolic syndrome was found in 61.5% with NAFLD.TAJ 2015; 28(2): 44-51

scholarly journals A cross sectional study: to determine the prevalence and risk factors of non-fatty alcoholic liver diseases among diabetics-I and II

2020 ◽  
Vol 7 (2) ◽  
pp. 283
Author(s):  
Geetha Navuduri ◽  
Asma .
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Cross Sectional ◽  
Alcoholic Fatty Liver ◽  
Waist Hip Ratio ◽  
Alcoholic Fatty Liver Disease

Background: Non Alcoholic Fatty Liver Disease (NAFLD) is an important health problem globally as well as in India. The present was taken to determine the prevalence of NAFLD among diabetics attending a tertiary care hospital in Telangana.Methods: A total of 75 subjects who were all diabetics were taken. The diagnosis of NAFLD was done using Ultra sonogram. Preliminary information along with duration of diabetes, Waist Hip Ratio, Body Mass Index, Triglycerides and Cholesterol was collected and analyzed.Results: The prevalence of NAFLD among diabetics was 41.3%. Majority of the subjects belonged to age group of 41-60 years. The prevalence of NAFLD among females was 35.99%. Among patients who had Non-alcoholic fatty liver disease 74.19% had Waist Hip ratio >1. Almost 90.3% had higher levels of triglycerides (>180 mg/dl).Conclusions: The prevalence of NAFLD among diabetics was comparatively high. Early diagnosis, treatment, awareness and education is needed to reduce the burden of NAFLD.

scholarly journals Carotid Intima-media Thickness in Patients with Non-alcoholic Fatty Liver Disease Attending a Tertiary Care Center: A Descriptive Cross-sectional Study

2021 ◽  
Vol 59 (237) ◽  
Author(s):  
Bom BC ◽  
Raj Kishwor Jaiswal ◽  
Prashant Kumar Gupta ◽  
Rajan Paudel ◽  
Raj Kumar Subedi
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Care Center ◽  
Tertiary Care ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Alcoholic Fatty Liver ◽  
Media Thickness ◽  
Alcoholic Fatty Liver Disease

Introduction: Non-alcoholic fatty liver disease is fatty infiltration of the liver in the absence of other causes of steatosis. It is strongly associated with central adiposity, high body mass index, insulin resistance states, hypertension, hyperlipidemia which are features of metabolic syndrome. The objective of study is to find out the carotid intima-media thickness of non alcoholic fatty liver disease patients attending a tertiary care center. Methods: This was a descriptive cross sectional study conducted at National Academy of Medical Sciences, Bir Hospital from July 2018 to June 2019 among 70 diagnosed cases of non alcoholic fatty liver disease based on ultrasound findings. Data collection was started after receiving ethical approval from Institutional Review Board of the Institute. Convenience sampling method was used. Data were entered using Microsoft Excel. The carotid intima-media thickness of both sides were measured by ultrasound. Statistical Package for Social Sciences version 20 was used for analysis. Results: Out of 70 cases, the mean carotid intima-media thickness was 0.7140±0.1796mm on right and 0.7161±0.1828mm on left side. Among 70 cases 45 (64.3%) were Grade II non alcoholic fatty liver disease and 25 (35.7%) were Grade I. It was 0.5720±0.1275mm and 0.7929±0.1546mm in Grade I and II non alcoholic fatty liver disease cases respectively on right side whereas it was 0.5676±0.1259mm and 0.7987±0.1557mm respectively on left side. Conclusions: This study showed increased carotid intima-media thickness in non alcoholic fatty liver disease cases.

scholarly journals Prevalence of Non-alcoholic Fatty Liver Disease and Its Associated Factors in Admixed Individuals With Type 1 Diabetes: a Cross-sectional Study in a Tertiary Care Center in Brazil

2021 ◽  
Author(s):  
Bianca Senger Vasconcelos Barros ◽  
Fernanda Cruz Monteiro ◽  
Carlos Terra ◽  
Marilia Brito Gomes
Keyword(s):  
Metabolic Syndrome ◽  
Type 1 Diabetes ◽  
Liver Disease ◽  
Fatty Liver Disease ◽  
Care Center ◽  
Tertiary Care ◽  
Tertiary Care Center ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Abstract Background: Data on non-alcoholic fatty liver disease (NAFLD) in admixed individuals with type 1 diabetes (T1D) is lacking. We investigated NAFLD in an admixed population with T1D from a tertiary care center in Brazil. Methods: Ninety-five participants with T1D, aged 39 ± 13 years, with disease duration of 21 ± 9 years, being 55 (57.9%) females, from a university hospital in Rio de Janeiro, were screened for NAFLD with hepatic ultrasound (US) and transient elastography (TE). Results: Prevalence of NAFLD was, respectively, 12.6% and 16.8% when US and TE were used. Fibrosis was present in 8% of participants. A total of 31.6% of participants had at least one of the hepatic exams altered, which was associated with higher anthropometric measurements, presence of metabolic syndrome and higher triglycerides levels, even within the normal range.Conclusion: In our study, prevalence of NAFLD in US approximates from the one found with TE. Screening should be reserved for participants with T1D and metabolic syndrome, as this was the main factor associated with NAFLD. Triglycerides levels were the only component of metabolic syndrome associated with NAFLD. Further studies are necessary to determine the best screening strategy for NAFLD in individuals with T1D from admixed populations.

scholarly journals A 12-week multi-component dietary intervention improves markers of non-alcoholic fatty liver disease in Irish patients in tertiary care

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Deirdre Ní Fhloinn ◽  
Ciara Wright ◽  
Sara Naimimohasses ◽  
Stephen Finn ◽  
Suzanne Norris ◽  
...  
Keyword(s):  
Weight Loss ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Dietary Intervention ◽  
Tertiary Care ◽  
Intervention Group ◽  
Post Intervention ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

AbstractNon-alcoholic fatty liver disease (NAFLD) is a significant public health concern closely linked to obesity, affecting an estimated 25% of adults in Europe. Understudied in Ireland, the aim of this research was to examine the effects of a 12-week multi-component dietary intervention on weight loss and markers of liver injury in Irish NAFLD patients in tertiary care. Biopsy confirmed NAFLD patients (n = 27) were recruited from St James’ Hospital in Dublin, Ireland. Consenting participants underwent a 12-week moderate-intensity intervention incorporating weekly group nutritional education, behavioural change and group support, as well as individualised advice and weigh-ins from a trained nutritionist. Control group participants were given routine clinical care. All participants were clinically reviewed before, immediately after, and 3 months post intervention. Individuals (n = 12) with histological evidence of steatohepatitis underwent a repeat liver biopsy on completion of the intervention. Detailed dietary assessment was performed using both a 4-day diet diary (4DDD) and a novel, recently validated, short food frequency questionnaire (SFFQ) designed specifically to assess habitual intakes of food items related to NAFLD. Nutrient intakes were analysed using myFood24TM dietary analysis software, and the Mediterranean diet quality score (MDQS) was used to assess the overall change in dietary patterns. Of the 15 participants who completed the intervention, 80% (n = 12) achieved a weight loss exceeding 5%, with 47% (n = 7) achieving > 7%. There were significant improvements from baseline to week 12 in the intervention group for the majority of clinical parameters including HbA1c (p = 0.0054), liver enzymes (ALT, p = 0.0108; GGT, p = 0.0001) and transient elastography (kPA, p = 0.0308; CAP, p = 0.0081). However, these results failed to maintain significance when analysed compared to controls. The overall dietary pattern was significantly improved after 12 weeks as assessed by the MDQS (p = 0.03), with no apparent compromise in micronutrient intake despite the energy reduction. Reductions in energy, saturated fat, carbohydrate and sugar intakes at 12 weeks, were maintained at three months follow up. Analysis of pre- and post-intervention liver biopsies in the intervention group demonstrated a clinically significant improvement in NAS score (p = 0.0273), attributable to reductions in hepatic steatosis (p = 0.0078). A significant correlation was observed between improvement in liver histology and change in sugar intake (r = 0.7534, p = 0.0093). Although results were somewhat limited by small sample size, nutritional education achieved beneficial dietary changes that persisted after the intervention ceased. Notably, achieving reductions in sugar intakes may be particularly beneficial in reducing the severity of hepatic steatosis in Irish adults with NAFLD.

scholarly journals assosiation of non alcholic fatty liver disease with coronary artery disease

2018 ◽  
Vol 50 (4) ◽  
Author(s):  
Muhammad saad Jibran
Keyword(s):  
Coronary Artery Disease ◽  
Liver Disease ◽  
Coronary Artery ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
P Value ◽  
Cross Sectional ◽  
Alcoholic Fatty Liver ◽  
Artery Disease ◽  
Alcoholic Fatty Liver Disease

OBJECTIVE: To determine the association between non alcoholic fatty liver disease and coronary artery disease. METHODOLOGY: This cross sectional study is conducted from July 2016 to December 2016, in cardiology unit, Lady reading hospital. By using non probability consecutive sampling, patients of all age groups and either gender, presenting to cath: lab for coronary angiography, indicated for angina CCS III, were included in the study. All patients fulfilling inclusion and exclusion criteria were subjected to screening for NAFLD by using ultrasonography. Patients were classified into having no, mild, moderate and sever NAFLD. Correlation between NAFLD and CAD, confirmed on cath: studies, was done using Spearman’s rho test. RESULTS: Total of 370 patients with mean age of 55.36 ± 10.07 years were enrolled in the study, of which 44.6% were females. Known risk factors for CAD like Diabetes mellitus, hypertension, and smoking were present in 63.5%, 64.9% and 23% respectively. 28.4% of patients had no NAFLD, 28.4% had mild, 28.4% had moderate and 14.4% had sever NAFLD. 12.2% had no CAD while mild, moderate and sever disease was present in 36.5%, 31.1% and 2.3% respectively. By using chi square test co relation co efficient between NAFLD and CAD was calculated and came out to be 285.536 ( p value <0.000). NAFLD also increased the odds of having CAD by 2.9 times with a p value for odd ratio <0.000. CONCLUSION: NAFLD is strongly associated as an independent risk factor with CAD and increases the odds of having CAD. KEY WORDS:  NAFLD= Non alcoholic fatty liver disease, CAD= Coronary artery disease, CCS= Canadian classification scale, Cath:= Cardiac catheterization

scholarly journals PREVALENCE OF NON-ALCOHOLIC FATTY LIVER DISEASE IN HYPOTHYROIDISM IN A TERTIARY CARE HOSPITAL IN EASTERN INDIA

2017 ◽  
Vol 6 (79) ◽  
pp. 5589-5593 ◽  
Author(s):  
Rina Mohanty ◽  
Samarendra Nath Das ◽  
Aujjwalya Kumar Jena ◽  
Sarita Behera ◽  
Nirmal Chandra Sahu ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Eastern India ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease
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