scholarly journals Papillary glioneuronal tumor growing slowly for 26 years: illustrative case

2021 ◽  
Vol 2 (1) ◽  
Author(s):  
Kazuma Shinno ◽  
Yoshiki Arakawa ◽  
Sachiko Minamiguchi ◽  
Yukinori Terada ◽  
Masahiro Tanji ◽  
...  
Keyword(s):  
Slow Growth ◽  
Epileptic Seizures ◽  
Cerebral Hemispheres ◽  
World Health ◽  
Glioneuronal Tumor ◽  
Illustrative Case ◽  
Glial Tumor ◽  
Health Organization ◽  
Mri Study ◽  
Glioneuronal Tumors

BACKGROUND Papillary glioneuronal tumors (PGNTs) are classified as a type of World Health Organization grade I mixed neuronal-glial tumor. Most PGNTs involve cystic formations with mural nodules and solid components in the cerebral hemispheres, and PGNTs occur mainly in young adults. The long-term prognosis of PGNTs remains unclear. OBSERVATIONS A 38-year-old male had been diagnosed with an arachnoid cyst associated with epilepsy in a local hospital. The initial magnetic resonance imaging (MRI) study showed the tumor as a heterogeneously enhanced nodule in the left postcentral gyrus. Subsequent MRI studies showed slow growth of the tumor for 26 years. He underwent gross total resection to control his epilepsy. The histopathological findings revealed pseudopapillary structures involving hyalinized blood vessels with a single or pseudostratified layer of cuboidal glial cells with round nuclei and scant cytoplasm. At the periphery of the lesion, Rosenthal fibers and acidophilic granule bodies were observed in the gliotic brain tissue. Immunohistochemically, some interpapillary cells were positive for NeuN. On the basis of these findings, the tumor was diagnosed as a PGNT. LESSONS This PGNT showed slow growth for 26 years. When recognizing a slowly growing tumor in the cerebral hemispheres of relatively young people that is associated with epileptic seizures, PGNT should be considered as a differential diagnosis.

scholarly journals Rosette-forming Glioneuronal Tumors in the Posterior Third Ventricle

2013 ◽  
Vol 40 (6) ◽  
pp. 885-888 ◽  
Author(s):  
Ibrahim Alnaami ◽  
Keith Aronyk ◽  
Jian-Qiang Lu ◽  
Edward S. Johnson ◽  
Cian O'Kelly
Keyword(s):  
Third Ventricle ◽  
Case Series ◽  
Neurofibromatosis Type ◽  
Pineal Region ◽  
World Health ◽  
Glioneuronal Tumor ◽  
First Case ◽  
The Central Nervous System ◽  
Health Organization ◽  
Glioneuronal Tumors

Rosette-forming glioneuronal tumor (RGNT) is a rare brain tumor found almost exclusively within the fourth ventricle. These grade I tumors were first included in the World Health Organization (WHO) Classification for the central nervous system in 20071. Since then, approximately 49 cases have been published.There are no reported cases of RGNT within the third ventricle, although this tumor has also been described in the pineal region, the tectum and within the aqueduct. Supratentorial localization is quite rare, with only three published: one was found in the septum pellucidum, another within the optic nerve in neurofibromatosis type 1 (NF1) patient and one in a patient with multiple RGNT in the lateral ventricle. The authors report the first case series in the literature of RGNT occurring within the posterior third ventricle.

scholarly journals Disseminated Cerebrospinal Embryonal Tumor in the Adult

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Alessandro Caporlingua ◽  
Daniele Armocida ◽  
Federico Caporlingua ◽  
Gennaro Lapadula ◽  
Grazia Maria Elefante ◽  
...  
Keyword(s):  
Adult Patient ◽  
Cauda Equina ◽  
World Health ◽  
Surgical Removal ◽  
Illustrative Case ◽  
Embryonal Tumor ◽  
Histologic Diagnosis ◽  
Heterogeneous Neoplasm ◽  
Health Organization ◽  
Whole Spine

Introduction. According to the 2016 World Health Organization classification of Tumors of the Central Nervous System, the term Primitive Neuroectodermal Tumor has been replaced by the term Embryonal Tumor (ET). We present a case of disseminated cerebrospinal ET presenting in an adult patient.Illustrative Case. A 49-year-old male presenting with low back pain, dysuria, and hypoesthesia of the lower extremities referred to our emergency department. Brain and whole spine contrast-enhanced MRI documented a diffusively disseminated heterogeneous neoplasm with intradural extra- and intramedullary involvement of the cervicothoracic tract and cauda equina. A primary biopsy of the lumbosacral localization was performed through L5 bilateral laminectomy. Histologic diagnosis was Embryonal Tumor Not Otherwise Specified. The patient underwent chemotherapy with postoperative adjuvant alternating Vincristine-Doxorubicin-Ifosfamide (VAI) and Ifosfamide-Etoposide (IE).Discussion. Spinal ETs are exceedingly rare especially when presenting in the adult patient. Neurosurgical and oncologic management is still unclear. When feasible, surgical removal should always be performed to obtain a histologic diagnosis. Postoperative adjuvant therapy might entail both chemo- and radiotherapy; however a consensus on this matter is still lacking.

scholarly journals Primary intraosseous meningioma of the vertebra: illustrative case

2021 ◽  
Vol 2 (16) ◽  
Author(s):  
Ue-Cheung Ho ◽  
Koping Chang ◽  
Yen-Heng Lin ◽  
Yu-Cheng Huang ◽  
Fon-Yih Tsuang
Keyword(s):  
Surgical Planning ◽  
Preoperative Assessment ◽  
World Health ◽  
Illustrative Case ◽  
En Bloc ◽  
Total En Bloc Spondylectomy ◽  
Lower Back ◽  
Bloc Spondylectomy ◽  
Health Organization ◽  
Intraosseous Meningioma

BACKGROUND Primary intraosseous meningiomas (PIMs) are rare, and PIMs of the vertebrae have not yet been reported. The authors report a case of primary meningioma arising from the vertebrae. OBSERVATIONS A 49-year-old man presented with lower back pain and numbness in both lower extremities. Lumbar spine magnetic resonance imaging revealed an L2 pathological fracture with epidural and paraspinal invasion. The patient had undergone a first palliative decompression and fixation surgery, and the diagnosis turned out to be a World Health Organization grade III anaplastic meningioma based on histopathology. The tumor had progressed after first operation and radiation therapy, and the patient was referred to the authors’ institute for excision. The patient had an uneventful postoperative course after a revisional total en bloc spondylectomy of L2. LESSONS The authors present a rare case of PIM of the vertebrae with epidural and paraspinal invasion. Careful preoperative assessment and surgical planning is crucial for successful patient management.

scholarly journals Rosette-forming glioneuronal tumor: an illustrative case and a systematic review

2020 ◽  
Vol 2 (1) ◽  
Author(s):  
Caleb P Wilson ◽  
Arpan R Chakraborty ◽  
Panayiotis E Pelargos ◽  
Helen H Shi ◽  
Camille K Milton ◽  
...  
Keyword(s):  
Systematic Review ◽  
Aggressive Behavior ◽  
Case Reports ◽  
World Health ◽  
Glioneuronal Tumor ◽  
Illustrative Case ◽  
Low Grade ◽  
Search Term ◽  
Who Grade ◽  
Mri Features

Abstract Background Rosette-forming glioneuronal tumors (RGNTs) are rare, low-grade, primary CNS tumors first described in 2002 by Komori et al. RGNTs were initially characterized as a World Health Organization (WHO) grade I tumors typically localized to the fourth ventricle. Although commonly associated with an indolent course, RGNTs have the potential for aggressive behavior. Methods A comprehensive search of PubMed and Web of Science was performed through November 2019 using the search term “rosette-forming glioneuronal tumor.” Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. English, full-text case reports and series with histopathological confirmation were included. Patient demographics, presentations, MRI features, tumor location, treatment, and follow-up of all 130 cases were extracted. Results A 19-year-old man with a history of epilepsy and autism presented with acute hydrocephalus. MRI scans from 2013 to 2016 demonstrated unchanged abnormal areas of cortex in the left temporal lobe with extension into the deep gray-white matter. On presentation to our clinic in 2019, the lesion demonstrated significant progression. The patient’s tumor was identified as RGNT, WHO grade I. One hundred thirty patients were identified across 80 studies. Conclusion RGNT has potential to transform from an indolent tumor to a tumor with more aggressive behavior. The results of our systematic review provide insight into the natural history and treatment outcomes of these rare tumors.

scholarly journals The rosette-forming glioneuronal tumor mimicked cerebral cysticercosis: a case report

2021 ◽  
Author(s):  
Dan Zhu ◽  
Ailan Cheng ◽  
Nickita T. L. Benons ◽  
Shuguang Chu
Keyword(s):  
Case Report ◽  
Brain Parenchyma ◽  
World Health ◽  
Cerebellar Hemisphere ◽  
Glioneuronal Tumor ◽  
History Of ◽  
Cerebral Cysticercosis ◽  
Magnetic Resonance Imaging Mri ◽  
Health Organization ◽  
The Right

Abstract Introduction Rosette-forming glioneuronal tumor (RGNT) is a rare variety of slow growing mixed glioneuronal tumor involving primarily fourth ventricular region. This is a comprehensive analysis of a 22-year-old woman with RGNT composed of mainly cystic components. In addition, the case showed multiple lesions located in brain parenchyma which mimicked cerebral cysticercosis. Here, we analyzed this case and listed some characteristics of RGNTs in reported literature which occurring in atypical locations for further understanding it. Case report A 22-year-old woman presented with a history of transient dizziness, nausea, and vomiting. Magnetic resonance imaging (MRI) showed multiple cystic lesions in brain parenchyma and then the patient was diagnosed with cerebral cysticercosis possibility. Empirical anti-infective therapy in addition to a follow-up post 2 weeks of MRI examination showed the lesions unchanged. Finally, a biopsy of the right cerebellar hemisphere lesions verified RGNT. Conclusion RGNT is an uncommon tumor classified as grade I glioma by World Health Organization (WHO) with slightly longer course. The imaging findings of RGNT are not specific especially in atypical areas. RGNT is rare, but we should also consider the possibility in diagnosis and differential diagnosis.

scholarly journals Modeling of chronic epilepsy in animals through chemical methods

2020 ◽  
Vol 18 (4) ◽  
pp. 185-196
Author(s):  
E. V. Egorova ◽  
D. V. Dmitrenko ◽  
A. A. Usoltseva ◽  
A. M. Iptyshev ◽  
N. A. Shnayder ◽  
...  
Keyword(s):  
Epileptic Seizures ◽  
World Health ◽  
Chronic Epilepsy ◽  
Advantages And Disadvantages ◽  
Chemical Models ◽  
The World ◽  
Convulsive Seizures ◽  
Health Organization ◽  
Assessment Scales

According to the World Health Organization, the prevalence of epilepsy in the world is high, at about 0.5–1% of the world’s population. In 20–40% of cases, according to various sources, it is not possible with standard treatment methods to achieve control over attacks, which significantly impairs the patient’s quality of life, increases economic costs, and poses a difficult task for the doctor to select the optimal treatment to reduce the frequency of attacks. This explains the urgency of creating new and modifying classical antiepileptic drugs (AEDs), as well as finding optimal and safe ways of administering and delivering the drugs. To study the mechanisms of AEDs’ effect on various pathways of epileptogenesis, simulation of convulsive seizures and chronic epilepsy in animals is used; for this purpose, mechanical, physical, chemical, and genetic models of epilepsy are used. The present review discusses chemical models of chronic epilepsy, which are most often used in experimental neuroscience today. It also describes the characteristics, advantages and disadvantages of each of them, the specificity of the study where they can be used and the assessment scales for epileptic seizures in animals.

scholarly journals Review of the World Health Organization classification of tumors of the nervous system

2002 ◽  
Vol 10 (3) ◽  
pp. 175-177 ◽  
Author(s):  
Slobodan Dozic ◽  
Dubravka Cvetkovic-Dozic ◽  
Milica Skender-Gazibara ◽  
Branko Dozic
Keyword(s):  
Nervous System ◽  
Who Classification ◽  
Third Ventricle ◽  
Large Cell ◽  
World Health ◽  
Proliferation Index ◽  
Glioneuronal Tumor ◽  
Nervous System Tumors ◽  
Health Organization

(Conclusion) Classifications of the nervous system tumors should be neither static nor definitive. The most recent, third, current WHO classification of nervous system tumors was published in 2000. Many substantial changes were introduced. New entities include the chordoid glioma of the third ventricle, the atypical teratoid/rhabdoid tumor, cerebellar liponeurocytoma (the former lipomatous medulloblstoma of the cerebellum), solitary fibrous tumor and perineurioma. The new tumor variants include the large cell medulloblastoma, tanacytic ependymoma and rhabdoid meningioma. Several essential changes were introduced in the meningiomas regarding histological subtypes, grading and proliferation index. In addition to new entities described in the 2000 WHO classification there are newly brain tumor entities and tumor variants, which are not included in the current classification due to the insufficient number of reporeted cases, for example papillary glioneuronal tumor, rosetted glioneuronal tumor, lipoastrocytoma and lipomatous meningioma. They will be probably accepted in the next WHO classificaton. In the current WHO classification the importance of cytogenetic and molecular biologic investigation in the understanding and further classifications of these tumors has been emphasized.

scholarly journals Mobile treatment for epileptic seizures using little scale electronic sensors

2018 ◽  
Vol 7 (1.8) ◽  
pp. 108
Author(s):  
Vasumathi Devi Majety ◽  
G Murali
Keyword(s):  
Electronic Device ◽  
Sensory System ◽  
Epileptic Seizures ◽  
World Health ◽  
The World ◽  
Frame Work ◽  
Health Organization ◽  
The Individual ◽  
Abnormal Behaviors ◽  
Electronic Sensors

Epilepsy-Abnormal behaviors (neuro disorder) of a patient.The epileptic seizure patient need an ongoing frame work. It must support in acute cases. The brilliant epilepsy recognition and ready framework is a propelled innovation by which an electronic device is introduced. Utilizing that pack, the life of the individual who is truly affecting with the condition can be anticipated. As per World Health Organization (WHO), epilepsy is a standout amongst the most well-known essential sicknesses of the focal sensory system around the world [1], which is exasperated by the sudden variable that portrays the event of an epileptic occasion. In this manner, the capacity to recognize scene preceding its beginning is introduced as a relief variable to the upsetting effects that emerge from this situation [2]. The casing will be tolerable, confirms the condition and also alerts by a SMS to the the specialist in question for the life of the patient. To realize all the above plan, mainly utilized four modules: scaled down scale controller, KEIL module, ARDUINO module and GSM module.

scholarly journals An overview of seizures and epilepsy in rabbits: etiological differences and clinical management

2021 ◽  
pp. 159-164
Author(s):  
E. Gülersoy ◽  
S.S. İyigün ◽  
B.B. Erol
Keyword(s):  
Recurrent Events ◽  
Neurological Diseases ◽  
Companion Animals ◽  
Epileptic Seizures ◽  
Brain Disease ◽  
World Health ◽  
Behavioral Alterations ◽  
Environmental Consequences ◽  
Risk Of Death ◽  
Health Organization

World Health Organization data suggest that neurological disorders are an important and growing cause of morbidity. One of the most common neurological disorder affecting people is epilepsy. Many companion animal neurological diseases share epidemiologic, pathophysiologic and clinical features with their human counterparts. In companion animals, affected species are mostly dogs, cats and rabbits. Seizure is defined as the clinical manifestation of abnormal electrical activity in the brain. Epilepsy is a brain disease characterized by the psychological, cognitive, social and environmental consequences of seizures. The epileptic seizures are recurrent events characterized by behavioral alterations that reflect the underlying neural mechanisms of the disease. In most cases, the disease can be diagnosed by anamnesis or observing the seizure. There are many reviews and researches about epilepsy and epileptic seizures in companion animals such as dogs and cats but not in rabbits. There are several causes of epilepsy in rabbits including viral, bacterial, parasitic, metabolic, respiratory, cardiovascular, nutritional, toxic, traumatic, enviromental and non-epileptic causes. Rabbits can be considered suitable for seizure and epilepsy investigations due to their recurrent seizures with low risk of death. As mentioned, there are several causes of epilepsy in rabbits but still to elucidate the exact mechanism of epilepsy and epileptic seizures in rabbits more studies need to be carried out. Despite the advances in the disease management, epilepsy is still an important cause of disability and mortality in both humans and companion animals. As tonic-clonic seizures with brainstem origin mostly affect children, epileptic seizures in rabbits may be a good model for further studies. Key words: Brain disease, epilepsy, neural disturbances, behavioral alterations, rabbit, seizure.

scholarly journals Cerebellar liponeurocytoma: a newly recognized clinico-pathological entity

2002 ◽  
Vol 60 (3B) ◽  
pp. 725-729 ◽  
Author(s):  
Nádia Montagna ◽  
Daniel Moreira ◽  
Luiz Carlos Vaz ◽  
Marcelo Reis
Keyword(s):  
World Health ◽  
Cerebellar Hemisphere ◽  
Rare Tumor ◽  
Present Case Report ◽  
The World ◽  
Cerebellar Liponeurocytoma ◽  
Prognostic Implications ◽  
Health Organization ◽  
The Right ◽  
Glioneuronal Tumors

The term "cerebellar liponeurocytoma", recently adopted by the World Health Organization Working Group (WHO), replaced many other different terms used up to now to give name to this rare tumor. To our knowledge, less than 20 cases have been related up to now under different names like as "lipomatous medulloblastoma, lipidized medulloblastoma, neurolipocytoma, medullocytoma and lipomatous glioneurocytoma". The new nomenclature eliminates the word "medulloblastoma", reinforces its benign caracter, and includes it in the category of glioneuronal tumors. We describe an adictional case of this distinct clinico-pathological entity removed from the right cerebellar hemisphere of a 53-year-old woman. With the present case report, we hope to contribute to the knowledge on the diagnostic and prognostic implications derived from the finding of mature adipose-like tissue within a medulloblastomatous tumour.

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