scholarly journals Disseminated Cerebrospinal Embryonal Tumor in the Adult

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Alessandro Caporlingua ◽  
Daniele Armocida ◽  
Federico Caporlingua ◽  
Gennaro Lapadula ◽  
Grazia Maria Elefante ◽  
...  
Keyword(s):  
Adult Patient ◽  
Cauda Equina ◽  
World Health ◽  
Surgical Removal ◽  
Illustrative Case ◽  
Embryonal Tumor ◽  
Histologic Diagnosis ◽  
Heterogeneous Neoplasm ◽  
Health Organization ◽  
Whole Spine

Introduction. According to the 2016 World Health Organization classification of Tumors of the Central Nervous System, the term Primitive Neuroectodermal Tumor has been replaced by the term Embryonal Tumor (ET). We present a case of disseminated cerebrospinal ET presenting in an adult patient.Illustrative Case. A 49-year-old male presenting with low back pain, dysuria, and hypoesthesia of the lower extremities referred to our emergency department. Brain and whole spine contrast-enhanced MRI documented a diffusively disseminated heterogeneous neoplasm with intradural extra- and intramedullary involvement of the cervicothoracic tract and cauda equina. A primary biopsy of the lumbosacral localization was performed through L5 bilateral laminectomy. Histologic diagnosis was Embryonal Tumor Not Otherwise Specified. The patient underwent chemotherapy with postoperative adjuvant alternating Vincristine-Doxorubicin-Ifosfamide (VAI) and Ifosfamide-Etoposide (IE).Discussion. Spinal ETs are exceedingly rare especially when presenting in the adult patient. Neurosurgical and oncologic management is still unclear. When feasible, surgical removal should always be performed to obtain a histologic diagnosis. Postoperative adjuvant therapy might entail both chemo- and radiotherapy; however a consensus on this matter is still lacking.

Patterns of skull base meningioma progression after failed radiosurgery

2007 ◽  
Vol 106 (1) ◽  
pp. 30-35 ◽  
Author(s):  
William T. Couldwell ◽  
Chad D. Cole ◽  
Ossama Al-Mefty
Keyword(s):  
Skull Base ◽  
Stereotactic Radiosurgery ◽  
Growth Patterns ◽  
World Health ◽  
Benign Tumors ◽  
Subtotal Resection ◽  
Surgical Removal ◽  
Skull Base Meningioma ◽  
Number Of Patients ◽  
Health Organization

Object Stereotactic radiosurgery has been reported to be an effective alternative to surgical removal of small to medium benign meningiomas as well as an adjuvant treatment modality to reduce the risk of tumor progression after subtotal resection. Its efficacy has been proved by excellent short-term radiosurgically demonstrated control rates, which have been reported to approach or exceed 90% in many contemporary studies involving the use of either linear accelerator–based systems or the Gamma Knife. Little is known, however, regarding the growth patterns of meningiomas that fail to stabilize after radiosurgery. Methods The authors report 13 cases of benign skull base meningiomas (World Health Organization Grade I) that demonstrated progression after radiosurgical treatment as a primary or an adjuvant therapy. Several tumors demonstrated rapid growth immediately after radiosurgical treatment, whereas other lesions progressed in a very delayed manner in some patients (up to 14 years after treatment). Regardless of the interval after which it occurs, tumor growth can be quite aggressive once it has begun. Conclusions Skull base meningioma growth can be aggressive after failed radiosurgery in some patients, and treatment failure can occur at long intervals following treatment. Special attention must be devoted to such significant occurrences given the increasing number of patients undergoing stereotactic radiosurgery for benign tumors, and careful extended (> 10 years) follow up must be undertaken in all patients after radiosurgery.

scholarly journals Surgical Management of Compound Odontoma Associated with Unerupted Tooth

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Andrea Pacifici ◽  
Daniele Carbone ◽  
Roberta Marini ◽  
Luciano Pacifici
Keyword(s):  
Therapeutic Option ◽  
World Health ◽  
Permanent Teeth ◽  
Surgical Removal ◽  
Pulp Tissue ◽  
World Health Organization Classification ◽  
Dental Tissues ◽  
Minimally Invasive Surgical ◽  
Health Organization ◽  
Compound Odontoma

Odontomas represent the most common type of odontogenic benign jaws tumors among patients younger than 20 years of age. These tumors are composed of enamel, dentine, cementum, and pulp tissue. According to the World Health Organization classification, two distinct types of odontomas are acknowledged: complex and compound odontoma. In complex odontomas, all dental tissues are formed, but appeared without an organized structure. In compound odontomas, all dental tissues are arranged in numerous tooth-like structures known as denticles. Compound odontomas are often associated with impacted adjacent permanent teeth and their surgical removal represents the best therapeutic option. A case of a 20-year-old male patient with a compound odontoma-associated of impacted maxillary canine is presented. A minimally invasive surgical technique is adopted to remove the least amount of bone tissue as far as possible.

scholarly journals The Effect of Oxytocin Massage on Increasing Milk Production

2020 ◽  
Vol 3 (2) ◽  
pp. 18
Author(s):  
Kartini Kartini ◽  
Atnesia Ajeng ◽  
Fitri Suaningsih
Keyword(s):  
Milk Production ◽  
Intervention Group ◽  
Sampling Technique ◽  
World Health ◽  
Control Group ◽  
Additional Information ◽  
Risk Of Death ◽  
Breast Milk Production ◽  
Health Organization ◽  
Whole Spine

Introduction Based on the research of the World Health Organization (WHO) at 2012 in six developing countries, the risk of death from infants aged 9-12 months increased by 40% if not breastfed, whereas infants under 2 months of increase reached 48%. Exclusive breastfeeding can reduce child mortality by 13%. Breast milk production is influenced by the hormone prolactin, while expenditure is influenced by the hormone oxytocin. Massage oxytocin is one solution to overcome the lack of launch production of milk in the whole spine (vertebrae) bone costae to the fifth-sixth and an attempt to stimulate the hormones prolactin and oxytocin after labour.Research Methodology The research uses quasi-experiment and samples taken as many as 30 people postpartum mothers who gave birth in a health center Balaraja, 15 people used as the control group, and 15 people used as the intervention group. The sampling technique in this research used Accidental Sampling.The results of the research there was a significant effect of massage oxytocin to increase milk production P = 0.000, no significant effect of massage oxytocin to increase BB baby P = 0.000, no significant effect of massage oxytocin with frequency BAK baby P = 0.679, there was no significant effect of massage oxytocin-the frequency of bowel baby P = 0.075.The conclusion from this research is there a massage effect of oxytocin on lactation and infant BB and no massaging effect of oxytocin on the frequency of bladder and bowel baby. Her recommendation is expected this research can be useful to add insight and knowledge and can be used as additional information for researchers in the future regarding oxytocin massage and for further research are expected to increase the number of samples to be research

scholarly journals A rare case of an intramedullary metastasis of a myxopapillary ependymoma

2019 ◽  
Vol 10 ◽  
pp. 83 ◽  
Author(s):  
Lino Fonseca ◽  
Marta Cicuendez ◽  
Francisco Martínez-Ricarte ◽  
Elena Martínez-Saez ◽  
Esteban Cordero ◽  
...  
Keyword(s):  
Cauda Equina ◽  
World Health ◽  
Subtotal Resection ◽  
Myxopapillary Ependymoma ◽  
World Health Organization Classification ◽  
History Of ◽  
Intradural Metastasis ◽  
Health Organization ◽  
Slow Growing

Background: Myxopapillary ependimoma (MPE) is a benign slow-growing tumor, and it has been designated histologically as a Grade I neoplasm according to the 2016 World Health Organization classification. Despite the benign character, dissemination and metastasis have occasionally been reported. The retrograde dissemination to other levels of the neuraxis is extremely rare, being more frequent to the intracranial compartment. Case Description: We hereby present a case of medullary metastasis of cauda equina MPE, with a history of having undergone a subtotal resection and postoperative adjuvant radiotherapy. The patient presents complaints of night dorsal pain attributable to intradural metastasis twenty-one years after the first surgical intervention. Conclusion: The case reported highlights the importance of long follow-up in patients with MPE, since the possibility of secondary seeding to distant craniospinal sites or local spinal sites after surgery, and radiotherapy should be considered in metastatic disease.

scholarly journals Papillary glioneuronal tumor growing slowly for 26 years: illustrative case

2021 ◽  
Vol 2 (1) ◽  
Author(s):  
Kazuma Shinno ◽  
Yoshiki Arakawa ◽  
Sachiko Minamiguchi ◽  
Yukinori Terada ◽  
Masahiro Tanji ◽  
...  
Keyword(s):  
Slow Growth ◽  
Epileptic Seizures ◽  
Cerebral Hemispheres ◽  
World Health ◽  
Glioneuronal Tumor ◽  
Illustrative Case ◽  
Glial Tumor ◽  
Health Organization ◽  
Mri Study ◽  
Glioneuronal Tumors

BACKGROUND Papillary glioneuronal tumors (PGNTs) are classified as a type of World Health Organization grade I mixed neuronal-glial tumor. Most PGNTs involve cystic formations with mural nodules and solid components in the cerebral hemispheres, and PGNTs occur mainly in young adults. The long-term prognosis of PGNTs remains unclear. OBSERVATIONS A 38-year-old male had been diagnosed with an arachnoid cyst associated with epilepsy in a local hospital. The initial magnetic resonance imaging (MRI) study showed the tumor as a heterogeneously enhanced nodule in the left postcentral gyrus. Subsequent MRI studies showed slow growth of the tumor for 26 years. He underwent gross total resection to control his epilepsy. The histopathological findings revealed pseudopapillary structures involving hyalinized blood vessels with a single or pseudostratified layer of cuboidal glial cells with round nuclei and scant cytoplasm. At the periphery of the lesion, Rosenthal fibers and acidophilic granule bodies were observed in the gliotic brain tissue. Immunohistochemically, some interpapillary cells were positive for NeuN. On the basis of these findings, the tumor was diagnosed as a PGNT. LESSONS This PGNT showed slow growth for 26 years. When recognizing a slowly growing tumor in the cerebral hemispheres of relatively young people that is associated with epileptic seizures, PGNT should be considered as a differential diagnosis.

scholarly journals Paraganglioma of the cauda equina – Case Report and Literature Review

2022 ◽  
Author(s):  
Arthur Araújo Massoud Salame ◽  
Bernardo de Andrada Pereira ◽  
Lygia Sampaio de Arruda Camara ◽  
Iogo Henrique de Oliveira Araújo ◽  
Filipe Moreira de Almeida Pinheiro ◽  
...  
Keyword(s):  
World Literature ◽  
Cauda Equina ◽  
Immunohistochemical Analysis ◽  
World Health ◽  
Benign Lesions ◽  
Spine Tumor ◽  
The World ◽  
Microsurgical Resection ◽  
Hypertensive Crises ◽  
Health Organization

AbstractParagangliomas of the cauda equina are tumors of rare incidence, with ∼ 220 cases described in the world literature. They are benign lesions, grade I by the World Health Organization (WHO), whose definitive diagnosis can only be made by immunohistochemical analysis. Its neuroendocrine nature is evidenced by the presence of chromogranin. The relevance of reporting this case is because paragangliomas of the cauda equina should be included among the differential diagnoses of intradural and extramedullary tumors, and especially because they can cause perioperative and intraoperative hypertensive crises by adrenergic discharge.The present study presents the case of a 36-year-old male patient diagnosed with a lumbar spine tumor located in the central spinal canal that presented as cauda equina syndrome involving 4 months of bilateral sciatica, paraparesis, urinary and fecal retention. The diagnosis of paraganglioma was confirmed by immunohistochemical positivity for chromogranin after microsurgical resection of the tumor.

scholarly journals Primary intraosseous meningioma of the vertebra: illustrative case

2021 ◽  
Vol 2 (16) ◽  
Author(s):  
Ue-Cheung Ho ◽  
Koping Chang ◽  
Yen-Heng Lin ◽  
Yu-Cheng Huang ◽  
Fon-Yih Tsuang
Keyword(s):  
Surgical Planning ◽  
Preoperative Assessment ◽  
World Health ◽  
Illustrative Case ◽  
En Bloc ◽  
Total En Bloc Spondylectomy ◽  
Lower Back ◽  
Bloc Spondylectomy ◽  
Health Organization ◽  
Intraosseous Meningioma

BACKGROUND Primary intraosseous meningiomas (PIMs) are rare, and PIMs of the vertebrae have not yet been reported. The authors report a case of primary meningioma arising from the vertebrae. OBSERVATIONS A 49-year-old man presented with lower back pain and numbness in both lower extremities. Lumbar spine magnetic resonance imaging revealed an L2 pathological fracture with epidural and paraspinal invasion. The patient had undergone a first palliative decompression and fixation surgery, and the diagnosis turned out to be a World Health Organization grade III anaplastic meningioma based on histopathology. The tumor had progressed after first operation and radiation therapy, and the patient was referred to the authors’ institute for excision. The patient had an uneventful postoperative course after a revisional total en bloc spondylectomy of L2. LESSONS The authors present a rare case of PIM of the vertebrae with epidural and paraspinal invasion. Careful preoperative assessment and surgical planning is crucial for successful patient management.

scholarly journals Pleomorphic liposarcoma arising on the cheek: a case report and review of the literature

2021 ◽  
Vol 7 (9) ◽  
pp. 1526
Author(s):  
Takahiro Suzuki ◽  
Kazuhiro Murakami ◽  
Naoya Noguchi ◽  
Fumi Shoji ◽  
Sachiko Fukaya ◽  
...  
Keyword(s):  
Facial Nerve ◽  
Present Report ◽  
Soft Tissue Tumors ◽  
High Rate ◽  
World Health ◽  
Surgical Removal ◽  
Pleomorphic Liposarcoma ◽  
Nerve Preservation ◽  
Health Organization ◽  
The Right

<p class="abstract">Pleomorphic liposarcoma, which is the rarest of the four liposarcoma types according to the World Health Organization (WHO) classification of soft tissue tumors, is associated with a high rate of recurrence and poor prognosis. In the present report, we present the case of a 69-year-old male patient with pleomorphic liposarcoma arising in the right cheek. The mass was initially considered as benign such as schwannoma due to the absence of facial nerve palsy. However, the mass grew rapidly, requiring surgical removal with facial nerve preservation. Pathological and molecular examination led to the definitive diagnosis of pleomorphic liposarcoma. The postoperative adjuvant radiotherapy was added, and there were no signs of recurrence at four-year follow-up.</p>

Malignant transformation of grade II ganglioglioma to glioblastoma: A case report

2012 ◽  
Vol 3 (2) ◽  
Author(s):  
Hrvoje Čupić ◽  
Tomislav Sajko ◽  
Nikolina Sesar ◽  
Mihovil Ivica ◽  
Leo Pažanin
Keyword(s):  
Malignant Transformation ◽  
Ganglion Cells ◽  
Histopathological Examination ◽  
World Health ◽  
Proliferation Index ◽  
Surgical Removal ◽  
Ki 67 ◽  
Grade Ii ◽  
Health Organization ◽  
P53 Immunoreactivity

AbstractGangliogliomas are well differentiated and slowly growing neuroepithelial tumors composed of neoplastic ganglion cells and neoplastic glial cells corresponding mostly to the World Health Organization grade I tumors. However, some of these tumors disclose histologically more malignant glial component and correspond to grade II or grade III tumors. We report a case of left temporal lobe tumor in a 42-year-old woman fulfilling the diagnostic criteria for atypical (grade II) ganglioglioma with high Ki-67 proliferation index and p53 immunoreactive tumor cells. In spite of gross total removal of the tumor, it recurred eight months after surgery. Histopathological examination of the recurrent tumor revealed that it had undergone malignant transformation into a glioblastoma. This case indicates that gangliogliomas with high Ki-67 proliferating index and p53 immunoreactivity should be carefully monitored for recurrence and malignant progression regardless of their morphological grading and seemingly total surgical removal.

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