Sports-related chronic repetitive head trauma as a cause of pituitary dysfunction

2011 ◽  
Vol 31 (5) ◽  
pp. E2 ◽  
Author(s):  
Julie Dubourg ◽  
Mahmoud Messerer
Keyword(s):  
Risk Factors ◽  
Head Trauma ◽  
Sports Injuries ◽  
Epidemiological Studies ◽  
Current Data ◽  
Pathophysiological Mechanisms ◽  
The Past ◽  
Pituitary Dysfunction ◽  
Important Concern ◽  
The World

Traumatic brain injury (TBI) is recognized as a cause of hypopituitarism even after mild TBI. Although over the past decade, a growing body of research has detailed neuroendocrine changes induced by TBI, the mechanisms and risk factors responsible for this pituitary dysfunction are still unclear. Around the world, sports—especially combative sports—are very popular. However, sports are not generally considered as a cause of TBI in most epidemiological studies, and the link between sports-related head trauma and hypopituitarism has not been investigated until recently. Thus, there is a paucity of data regarding this important concern. Because of the large number of young sports participants with near-normal life expectancy, the implications of undiagnosed or untreated postconcussion pituitary dysfunction can be dramatic. Understanding the pathophysiological mechanisms and risk factors of hypopituitarism caused by sports injuries is thus an important issue that concerns both medical staff and sponsors of sports. The aim of this paper was to summarize the best evidence for understanding the pathophysiological mechanisms and to discuss the current data and recommendations on sports-related head trauma as a cause of hypopituitarism.

Abstract 242: Prevalence Of Hypertension And Associated Anthropometric Risk Factors In Indigenous Adults Of Guatemala

Hypertension ◽  
2014 ◽  
Vol 64 (suppl_1) ◽  
Author(s):  
MENFIL A ORELLANA-BARRIOS ◽  
Kenneth Nugent ◽  
Camilo Pena ◽  
Herman Sanchez-Barrios ◽  
Jose R Lopez-Gutierrez
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Protective Factor ◽  
Epidemiological Studies ◽  
Descriptive Statistics ◽  
Developing Regions ◽  
Rural Regions ◽  
The World ◽  
Geographical Clustering ◽  
Crude Prevalence

Background: Hypertension epidemiological studies in developing regions of the world like rural Guatemala are lacking. Methods: A sample size of 1,104 subjects (552 females, all 18 years or older) was obtained through quota and geographical clustering in the entire Department of Sololá, Guatemala. Descriptive statistics and logistic regression were used. Results: Average systolic, diastolic and mean arterial pressures were significantly higher in men compared to women (116.24 vs. 113.80 mmHg, 75.24 mmHg vs. 72.69 mmHg, and 88.91 mmHg vs. 86.39 mmHg, respectively; all with p<0.05). The crude prevalence of HT was 12.5 % with no gender differences. Women had a significantly higher mean BMI than men (26.25 vs. 24.71, p< 0.001). An abnormally high WC was found in 12.7% of men and in 50.7% of women. Significant associations were found between the presence of HT, age ≥ 55 years and an elevated WC. The single most important isolated risk factor for HT was age in women (OR 6.76, CI 95% 3.59-12.72) and WC in men (OR 3.23, CI 95% 1.52-6.87). Increased BMIs (≥ 25 to 30 or ≥30) were not associated with HT in this study. Residing in Sololá's capital was a protective factor in women (OR 0.33, CI 95% 0.13-0.83). Conclusion: Hypertension and associated anthropometric risk factors are present in rural regions of Guatemala. Significant associations are found between gender, age ≥ 55 years, and increased WC but not with an increased BMI in this population.

“I feel fine. Do I really need to take a cholesterol pill?”

HIV ◽  
2020 ◽  
pp. 189-200
Author(s):  
Arvind Nishtala ◽  
Matthew J. Feinstein
Keyword(s):  
Risk Factors ◽  
Antiretroviral Therapy ◽  
Cardiovascular Diseases ◽  
Chronic Condition ◽  
Clinical Manifestations ◽  
Epidemiological Studies ◽  
Communicable Diseases ◽  
Non Communicable Diseases ◽  
The Past ◽  
Traditional Risk Factors

With widespread antiretroviral therapy (ART) accessibility and uptake, HIV has transitioned in many ways to a chronic condition marked by heightened risks of non-communicable diseases. Several clinical and epidemiological studies over the past two decades have demonstrated elevated risks for cardiovascular diseases (CVDs) among people with HIV. These risks appear to be particularly elevated among people with histories of long periods of uncontrolled viremia and CD4 lymphopenia, and dovetail with traditional risk factors (such as smoking) that are common among people with HIV. This chapter presents a discussion of the evolving epidemiology, clinical manifestations, and putative mechanisms of CVDs among people with HIV.

scholarly journals Obesity-related hypertension: possible pathophysiological mechanisms

2014 ◽  
Vol 223 (3) ◽  
pp. R63-R78 ◽  
Author(s):  
Ivana Vaněčková ◽  
Lenka Maletínská ◽  
Michal Behuliak ◽  
Veronika Nagelová ◽  
Josef Zicha ◽  
...  
Keyword(s):  
Risk Factors ◽  
Basic Research ◽  
Epidemiological Studies ◽  
Early Ontogeny ◽  
Detailed Knowledge ◽  
Critical Periods ◽  
Pathophysiological Mechanisms ◽  
Global Epidemic ◽  
The Metabolic Syndrome ◽  
Different Populations

Hypertension is one of the major risk factors of cardiovascular diseases, but despite a century of clinical and basic research, the discrete etiology of this disease is still not fully understood. The same is true for obesity, which is recognized as a major global epidemic health problem nowadays. Obesity is associated with an increasing prevalence of the metabolic syndrome, a cluster of risk factors including hypertension, abdominal obesity, dyslipidemia, and hyperglycemia. Epidemiological studies have shown that excess weight gain predicts future development of hypertension, and the relationship between BMI and blood pressure (BP) appears to be almost linear in different populations. There is no doubt that obesity-related hypertension is a multifactorial and polygenic trait, and multiple potential pathogenetic mechanisms probably contribute to the development of higher BP in obese humans. These include hyperinsulinemia, activation of the renin–angiotensin–aldosterone system, sympathetic nervous system stimulation, abnormal levels of certain adipokines such as leptin, or cytokines acting at the vascular endothelial level. Moreover, some genetic and epigenetic mechanisms are also in play. Although the full manifestation of both hypertension and obesity occurs predominantly in adulthood, their roots can be traced back to early ontogeny. The detailed knowledge of alterations occurring in the organism of experimental animals during particular critical periods (developmental windows) could help to solve this phenomenon in humans and might facilitate the age-specific prevention of human obesity-related hypertension. In addition, better understanding of particular pathophysiological mechanisms might be useful in so-called personalized medicine.

scholarly journals Incidence of insulin-dependent diabetes mellitus: An epidemiological study

1994 ◽  
Vol 40 (4) ◽  
pp. 61-64
Author(s):  
Ye. V. Trofimenko ◽  
N. B. Lebedev ◽  
N. V. Gubanov ◽  
Ye. N. Zlobina ◽  
I. I. Dedov
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Dependent Diabetes Mellitus ◽  
Epidemiological Studies ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
The Past ◽  
The World ◽  
The Usa ◽  
Insulin Dependent ◽  
Therapeutic Measures

Insulin-dependent diabetes mellitus (T1DM) is one of the most important problems of our time. This disease plays a significant role in the structure of chronic childhood pathology, leads to severe complications that invalidate a person, and significantly increases mortality at a young age. The study of the incidence of T1DM (the number of new cases of T1DM in a certain population within 1 year) allows you to get answers to a number of questions on its etiology and pathogenesis, to solve the problems of the need to allocate material resources for the organization of preventive and therapeutic measures. Information on the incidence of T1DM in the world applies in most cases to people under the age of 15 years, data for the age group up to 1820 years of age are less common. Epidemiological studies in various countries show an increase in the incidence of T1DM in children. This is shown by the example of Norway, the USA, Finland, Denmark from the 20s of our century, England - from the 50s and other countries over the past 20 years. It is possible to reliably distinguish a true increase in the incidence from an improvement in the detection of diabetes only on the basis of standardized epidemiological studies for certain periods of time. Many countries have compiled national childhood diabetes registries. Thus, in a number of countries standardized information on sex and age was obtained on the incidence of children with T1DM for at least 10 years, divided into 5-year periods. According to these data, the incidence rate has increased in the vast majority of countries over the past 10-20 years. It is noteworthy that the change, namely, an increase in the incidence of type 1 diabetes mellitus in children, is uneven. In some regions of the world, this indicator remained virtually unchanged over fairly long periods of time.

scholarly journals Global trends of obesity, malnutrition and dietary risk factors

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
G Grosso ◽  
M Di Cesare
Keyword(s):  
Risk Factors ◽  
Whole Grains ◽  
Current Data ◽  
Overweight And Obesity ◽  
Global Level ◽  
Global Trends ◽  
Dietary Risk Factors ◽  
Dietary Risk ◽  
The World ◽  
Minimum Number

Abstract Background The burden of malnutrition across the world remains unacceptably high. Children under five years are facing multiple burdens, including stunting and wasting; conversely, overweight and obesity among adults are at record levels while global trends in chronic non-communicable diseases (NCDs) are rising globally. Methods Data from the NCD Risk Factor Collaboration (NCD-RisC) and the Global Burden of Disease (GBD) Study and insights from the Global Nutrition Report will be discussed. Results No changes in age-standardised mean BMI in girls and boys from 1975 to 2016 were registered in eastern Europe, while an increase of up to 1.00 kg/m2 per decade was reported in central Latin America (for girls) and in Polynesia and Micronesia (for boys), with lower but significant variations over time all around the world. There has been some progress in reducing malnutrition at a global level but there are significant disparities in progress at the national and subnational level. Fewer than one in five children aged 6 to 23 months eat a minimally acceptable diet while only half of children aged 6 to 23 months get the recommended minimum number of meals. Regardless of wealth, children, adolescents and adults are eating too many refined grains and sugary foods and drinks, and not enough foods that promote health such as fruits, vegetables, legumes and whole grains. A total of 11 million deaths are attributable to dietary risk factors. High intake of sodium, low intake of whole grains, and low intake of fruits are the leading dietary risk factors for deaths globally. However, important differences between regions and outcome (i.e., cardiovascular disease vs. cancer) have been registered. Conclusions Current data allow us to assess what people are eating at global level, but nutrition quality in all countries and wealth groups pose a significant threat to achieving ideal targets. Focus on healthy diets to drive better nutrition everywhere is crucial to prevent NCDs globally.

scholarly journals Investigation of antihypothalamus and antipituitary antibodies in amateur boxers: is chronic repetitive head trauma-induced pituitary dysfunction associated with autoimmunity?

2010 ◽  
Vol 162 (5) ◽  
pp. 861-867 ◽  
Author(s):  
Fatih Tanriverdi ◽  
Annamaria De Bellis ◽  
Marina Battaglia ◽  
Giuseppe Bellastella ◽  
Antonio Bizzarro ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Head Trauma ◽  
Odds Ratio ◽  
Preliminary Evidence ◽  
Current Data ◽  
Immunofluorescence Method ◽  
Antipituitary Antibodies ◽  
Pituitary Dysfunction ◽  
First Time ◽  
Normal Controls

ObjectiveCurrent data clearly demonstrate that sports-related chronic repetitive head trauma due to boxing might result in hypopituitarism. However, the mechanism of sports-related traumatic brain injury-induced pituitary dysfunction is still unclear. In order to understand whether autoimmune mechanisms could play a role in the pituitary dysfunction due to sports-related head trauma, we investigated the presence of antipituitary antibodies (APAs) and antihypothalamus antibodies (AHAs) in amateur boxers.Patients and designSixty-one actively competing (n=44) or retired (n=17) male boxers (mean age, 26 years; range, 17–53) who had been evaluated regarding pituitary functions previously were included in the study. In all boxers and in 60 age/sex-similar normal controls, AHAs and APAs were investigated by an indirect immunofluorescence method.ResultsAHAs were detected in 13 of 61 boxers (21.3%), and APAs were detected in 14 of 61 boxers (22.9%), but in none of the normal controls. Pituitary dysfunction was significantly higher in AHA-positive boxers (46.2%) than in AHA-negative boxers (10.4%) (P=0.003). There was a significant association between AHA positivity and hypopituitarism due to boxing (odds ratio: 7.37, 95% confidence interval 1.8–30.8). There was no significant association between APA positivity and hypopituitarism.ConclusionsThis study demonstrates for the first time the presence of AHAs and APAs in boxers who were exposed to sports-related head trauma. Moreover, the present investigation provides preliminary evidence that AHAs are associated with the development of pituitary dysfunction in boxers, thus suggesting that autoimmunity may have a role in the pathogenesis.

scholarly journals A cross-sectional study of acute diarrhea in Pudong, Shanghai, China: prevalence, risk factors, and healthcare-seeking practices

2017 ◽  
Vol 145 (13) ◽  
pp. 2735-2744 ◽  
Author(s):  
J.-X. YU ◽  
W.-P. ZHU ◽  
C.-C. YE ◽  
C.-Y. XUE ◽  
S.-J. LAI ◽  
...  
Keyword(s):  
Risk Factors ◽  
Incidence Rate ◽  
Acute Diarrhea ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Common Cause ◽  
The Past ◽  
Community Residents ◽  
The World

SUMMARYDiarrhea is a common cause of morbidity and mortality and the incidence of diarrhea in the world has changed little over the past four decades. To assess the prevalence of and healthcare practices for diarrhea, a cross-sectional study was conducted in Pudong, Shanghai, China. In October 2014, a total of 5324 community residents were interviewed. Respondents were asked if they had experienced diarrhea (defined as ⩾3 passages of watery, loose, bloody, or mucoid stools within a 24-h period) in the previous month prior to the interview. The monthly prevalence of diarrhea was 4·1% (95% CI: 3·3–4·8), corresponding to an incidence rate of 0·54 episodes per person-year. The proportion of individuals with diarrhea who sought healthcare was 21·2% (95% CI: 13·4–29·0). Diarrhea continues to impose a considerable burden on the community and healthcare system in Pudong. Young age and travel were identified as predictors of increased diarrhea occurrence.

scholarly journals DIAGNOSTIC CRITERIA AND SURGICAL APPROACHES TO THE TREATMENT OF OVARIAN TUMOR NOMINATIONS

2020 ◽  
pp. 51-54
Author(s):  
M. O. Shcherbina ◽  
I. M. Shcherbina ◽  
O. V. Saltovsky
Keyword(s):  
Diagnostic Criteria ◽  
World Literature ◽  
Optimal Algorithm ◽  
Modern Medicine ◽  
Current Data ◽  
Ovarian Tumors ◽  
Surgical Approaches ◽  
Advantages And Disadvantages ◽  
The Past ◽  
The World

Resume. The aim of the work was to study modern diagnostic criteria and surgical approaches to the treatment of ovarian tumors. The objectives of the work were to highlight the arsenal of diagnostic and therapeutic capabilities of modern medicine for various ovarian tumors, discuss the advantages and disadvantages of methods and select the optimal algorithm for managing patients with this pathology. Materials and methods. A retrospective study of cases of ovarian tumors in patients over the past 5 years, studied the current data of the world literature on this topic. The conclusions of the work indicate the need for a comprehensive approach to the diagnosis and treatment of ovarian tumors and an individual approach to the patient in each case.

scholarly journals Comorbidity in chronic obstructive pulmonary disease and cardiovascular disease

2021 ◽  
Vol 20 (3) ◽  
pp. 2539
Author(s):  
A. M. Chaulin ◽  
D. V. Duplyakov
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Diagnosis And Treatment ◽  
Pulmonary Diseases ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Pathophysiological Mechanisms ◽  
The World

Comorbidity is one of the most significant problems of modern healthcare. Numerous studies have analyzed the possible pathogenetic mechanisms and relationships between a wide variety of diseases. Cardiovascular (CVD) and pulmonary diseases, in particular chronic obstructive pulmonary disease (COPD), have a number of the same risk factors and pathogenetic links, which aggravate each other's course. Moreover, CVD and COPD are among the most common diseases in the world. This review provides up-to-date information on the prevalence, risk factors and pathophysiological mechanisms underlying this unfavorable combination of diseases. Some problems of diagnosis and treatment of patients with COPD and CVD are also discussed.

A basic introduction to image processing using NIH-Image as a model

1994 ◽  
Vol 52 ◽  
pp. 392-393
Author(s):  
John Mansfield
Keyword(s):  
Image Processing ◽  
Digital Image ◽  
Image Acquisition ◽  
Digital Instrument ◽  
Novice User ◽  
Nih Image ◽  
The Past ◽  
Digital World ◽  
The World ◽  
Instrument Control

Advances in camera technology and digital instrument control have meant that in modern microscopy, the image that was, in the past, typically recorded on a piece of film is now recorded directly into a computer. The transfer of the analog image seen in the microscope to the digitized picture in the computer does not mean, however, that the problems associated with recording images, analyzing them, and preparing them for publication, have all miraculously been solved. The steps involved in the recording an image to film remain largely intact in the digital world. The image is recorded, prepared for measurement in some way, analyzed, and then prepared for presentation.Digital image acquisition schemes are largely the realm of the microscope manufacturers, however, there are also a multitude of “homemade” acquisition systems in microscope laboratories around the world. It is not the mission of this tutorial to deal with the various acquisition systems, but rather to introduce the novice user to rudimentary image processing and measurement.

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