scholarly journals The effects of experimentally induced Escherichia coli mastitis and flunixin meglumine administration on activity measures, feed intake, and milk parameters

2012 ◽  
Vol 95 (9) ◽  
pp. 4939-4949 ◽  
Author(s):  
E.E. Yeiser ◽  
K.E. Leslie ◽  
M.L. McGilliard ◽  
C.S. Petersson-Wolfe
Keyword(s):  
Escherichia Coli ◽  
Feed Intake ◽  
Flunixin Meglumine ◽  
Activity Measures ◽  
Experimentally Induced

scholarly journals Effect of experimentally-induced villus atrophy on adhesion of K88ac-positive Escherichia coli in just-weaned piglets

1988 ◽  
Vol 17 (2) ◽  
pp. 159-169 ◽  
Author(s):  
E. Cox ◽  
V. Cools ◽  
H. Thoonen ◽  
J. Hoorens ◽  
A. Houvenaghel
Keyword(s):  
Escherichia Coli ◽  
Weaned Piglets ◽  
Villus Atrophy ◽  
Experimentally Induced

scholarly journals Comparison of ampicillin-sulbactam regimens simulating 1.5- and 3.0-gram doses to humans in treatment of Escherichia coli bacteremia in mice.

1995 ◽  
Vol 39 (4) ◽  
pp. 930-936 ◽  
Author(s):  
P D Lister ◽  
C C Sanders
Keyword(s):  
Escherichia Coli ◽  
Body Weight ◽  
Mouse Model ◽  
Protective Efficacy ◽  
Clinical Isolates ◽  
Human Pharmacokinetics ◽  
Beta Lactamase ◽  
E Coli ◽  
Lethal Infection ◽  
Experimentally Induced

A mouse model of bacteremia was used to compare the efficacies of 1.5- and 3.0-g intravenous doses of ampicillin-sulbactam. Seven strains of Escherichia coli producing various levels of TEM-1 beta-lactamase were used as the challenge isolates. These strains included six clinical isolates (MICs from 2/1 micrograms/ml [with 2 and 1 microgram/ml being the respective concentrations of ampicillin and sulbactam] to 32/16 micrograms/ml) with similar degrees of virulence in mice and a laboratory genetic transformant (E. coli AFE) which hyperproduces TEM-1 (MIC = 128/64 micrograms/ml). Human pharmacokinetics were simulated by injecting mice subcutaneously twice (1 h apart) with ampicillin-sulbactam at concentrations of 40 mg/kg of body weight (1.5 g) and 80 mg/kg (3.0 g). Against two clinical isolates for which ampicillin-sulbactam MICs were < or = 8/4 micrograms/ml, no difference was observed in either the rate or level of killing between the two doses, and both doses were 100% protective against lethal infection. Against the four clinical isolates for which ampicillin-sulbactam MICs were between 16/8 and 32/16 micrograms/ml, a slight delay in killing was noted with three of the strains. This delay was followed by a rapid 2- to 3-log drop in the level of bacteremia, and both doses of ampicillin-sulbactam were 100% protective against lethal septicemia. With strain AFE, no killing was observed with the 40-mg/kg dose compared with a 2-log killing with the 80-mg/kg dose. This difference in killing correlated with a decreased protective efficacy of the 40-mg/kg dose. These data suggest that the 1.5-g preparation of ampicillin-sulbactam is as effective as the 3.0-g dose in the treatment of experimentally induced E. coli bacteremia, as long as ampicillin-sulbactam MICs are 32/16 micrograms/ml or less.

scholarly journals Efficacy of Two Therapy Regimens for Treatment of Experimentally Induced Escherichia coli Mastitis in Cows

1994 ◽  
Vol 77 (2) ◽  
pp. 453-461 ◽  
Author(s):  
S. Pyörälä ◽  
L. Kaartinen ◽  
H. Käck ◽  
V. Rainio
Keyword(s):  
Escherichia Coli ◽  
Experimentally Induced

Dairy cows under experimentally-induced Escherichia coli mastitis show negative emotional states assessed through Qualitative Behaviour Assessment

2018 ◽  
Vol 206 ◽  
pp. 1-11 ◽  
Author(s):  
Alice de Boyer des Roches ◽  
Alexandra Lussert ◽  
Marion. Faure ◽  
Vincent. Herry ◽  
Pascal. Rainard ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Dairy Cows ◽  
Emotional States ◽  
Qualitative Behaviour ◽  
Experimentally Induced

scholarly journals Influence of the intestinal microbiota on disease susceptibility in kittens with experimentally-induced carriage of atypical enteropathogenic Escherichia coli

2019 ◽  
Vol 231 ◽  
pp. 197-206 ◽  
Author(s):  
Victoria E. Watson ◽  
Megan E. Jacob ◽  
José M. Bruno-Bárcena ◽  
Sophia Amirsultan ◽  
Stephen H. Stauffer ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Intestinal Microbiota ◽  
Disease Susceptibility ◽  
Enteropathogenic Escherichia Coli ◽  
Experimentally Induced

scholarly journals Increasing dietary tryptophan in conjunction with decreasing other large neutral amino acids increases weight gain and feed intake in weaner pigs regardless of experimental infection with enterotoxigenic Escherichia coli

2020 ◽  
Vol 98 (8) ◽  
Author(s):  
Samantha O Sterndale ◽  
David W Miller ◽  
Josie P Mansfield ◽  
Jae C Kim ◽  
John R Pluske
Keyword(s):  
Escherichia Coli ◽  
Amino Acids ◽  
Feed Intake ◽  
Stress Responses ◽  
Plasma Cortisol ◽  
Average Daily Gain ◽  
Enterotoxigenic Escherichia Coli ◽  
Large Neutral Amino Acids ◽  
Neutral Amino Acids ◽  
Serum Serotonin

Abstract Dietary tryptophan (Trp) is a precursor for serotonin, a neuromediator involved in stress responses. Tryptophan competes with other large neutral amino acids (LNAA: tyrosine, isoleucine, leucine, valine, and phenylalanine) to cross the blood–brain barrier; therefore, the regulation of circulating LNAA can influence Trp availability in the cortex and serotonin biosynthesis. The hypothesis examined in this study was that increased supplementation of dietary Trp and a reduction in LNAA for weaned pigs experimentally infected with enterotoxigenic Escherichia coli (ETEC; F4) will increase Trp availability in plasma and reduce indices of the stress response, which will translate to reduced production losses. At 21 ± 3 d of age (mean ± SEM), 96 male pigs (Large White × Landrace) weighing 6.3 ± 0.98 kg (mean ± SEM) were individually penned and allocated to a 4 × 2 factorial arrangement of treatments, with respective factors being 1) four dietary standardized ileal digestible (SID) Trp and LNAA contents, being HTrpHLNAA (Low Trp-High LNAA; 0.24% SID Trp: 5.4% SID LNAA), HTrpHLNAA (Low Trp-Low LNAA; 0.24% SID Trp: 4.6% SID LNAA), HTrpHLNAA (High Trp-High LNAA; 0.34% SID Trp: 5.4% SID LNAA), and HTrpHLNAA (High Trp-Low LNAA; 0.34% SID Trp: 4.6% SID LNAA), and 2) without/with ETEC infection. Pigs were orally infected with 0.8 mL (3.6 × 109 CFU/mL) ETEC at days 7 and 8 after weaning. Pigs fed diets high in Trp irrespective of the level of LNAA (HTrpHLNAA and HTrpLLNAA) had higher plasma Trp concentrations (P &lt; 0.001) and a Trp:LNAA ratio (P &lt; 0.001) before infection and 6 d after infection. Following infection, noninfected pigs had higher plasma Trp (P = 0.03) and a Trp:LNAA ratio (P = 0.004) compared with pigs infected with ETEC. Plasma cortisol levels after infection were higher in ETEC-infected pigs (P = 0.05) and altering dietary Trp and LNAA concentrations did not influence (P &gt; 0.05) plasma cortisol. Pigs fed diet HTrpLLNAA had higher serum serotonin levels 24 h after infection (P = 0.02) compared with pigs fed diets LTrpLLNAA and HTrpHLNAA. Similarly, pigs fed diet HTrpLLNAA had a higher (P = 0.02) average daily gain during the 3-wk study. Overall, average daily feed intake tended to be higher in pigs fed an HTrpLLNAA diet compared with the other diets (P = 0.08). These results suggest that the increased supplementation of dietary Trp with reduced LNAA increased circulating Trp levels that, in turn, likely caused higher serum serotonin levels, irrespective of infection with ETEC, and improved aspects of post-weaning performance.

The efficacy of bovine lactoferrin in the treatment of cows with experimentally induced Escherichia coli mastitis

2004 ◽  
Vol 27 (4) ◽  
pp. 197-202 ◽  
Author(s):  
T. Kutila ◽  
L. Suojala ◽  
T. Lehtolainen ◽  
H. Saloniemi ◽  
L. Kaartinen ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Bovine Lactoferrin ◽  
Experimentally Induced
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