scholarly journals Short communication: Effects of β-lactoglobulin, stearoyl-coenzyme A desaturase 1, and sterol regulatory element binding protein gene allelic variants on milk production, composition, acidity, and coagulation properties of Brown Swiss cows

2012 ◽  
Vol 95 (1) ◽  
pp. 450-454 ◽  
Author(s):  
A. Cecchinato ◽  
C. Ribeca ◽  
A. Maurmayr ◽  
M. Penasa ◽  
M. De Marchi ◽  
...  
Keyword(s):  
Short Communication ◽  
Protein Gene ◽  
Regulatory Element ◽  
Allelic Variants ◽  
Brown Swiss ◽  
Communication Effects ◽  
Element Binding Protein ◽  
Sterol Regulatory Element ◽  
Binding Protein Gene ◽  
Β Lactoglobulin

scholarly journals The Gene-Gene Interaction of INSIG-SCAP-SREBP Pathway on the Risk of Obesity in Chinese Children

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Fang-Hong Liu ◽  
Jie-Yun Song ◽  
Xiao-Rui Shang ◽  
Xiang-Rui Meng ◽  
Jun Ma ◽  
...  
Keyword(s):  
Genetic Variants ◽  
Protein Gene ◽  
Risk Group ◽  
Binding Protein ◽  
Regulatory Element ◽  
Chinese Children ◽  
Increased Risk ◽  
Element Binding Protein ◽  
Sterol Regulatory Element ◽  
Binding Protein Gene

Background.Childhood obesity has become a global public health problem in recent years. This study aimed to explore the association of genetic variants in INSIG-SCAP-SREBP pathway with obesity in Chinese children.Methods.A case-control study was conducted, including 705 obese cases and 1,325 nonobese controls. We genotyped 15 single nucleotide polymorphisms (SNPs) of five genes in INSIG-SCAP-SREBP pathway, including insulin induced gene 1 (INSIG1), insulin induced gene 2 (INSIG2), SREBP cleavage-activating protein gene (SCAP), sterol regulatory element binding protein gene 1 (SREBP1), and sterol regulatory element binding protein gene 2 (SREBP2). We used generalized multifactor dimensionality reduction (GMDR) and logistic regression to investigate gene-gene interactions.Results.Single polymorphism analyses showed thatSCAPrs12487736 and rs12490383 were nominally associated with obesity. We identified a 3-locus interaction on obesity in GMDR analyses(P=0.001), involving 3 genetic variants ofINSIG2,SCAP,andSREBP2. The individuals in high-risk group of the 3-locus combinations had a 79.9% increased risk of obesity compared with those in low-risk group (OR=1.799, 95% CI: 1.475–2.193,P=6.61×10-9).Conclusion.We identified interaction of three genes in INSIG-SCAP-SREBP pathway on risk of obesity, revealing that these genes affect obesity more likely through a complex interaction pattern than single gene effect.

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