scholarly journals Identification of an Androgen Response Element in Intron 8 of the Sterol Regulatory Element-binding Protein Cleavage-activating Protein Gene Allowing Direct Regulation by the Androgen Receptor

2004 ◽  
Vol 279 (29) ◽  
pp. 30880-30887 ◽  
Author(s):  
Hannelore Heemers ◽  
Guy Verrijdt ◽  
Sophie Organe ◽  
Frank Claessens ◽  
Walter Heyns ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Protein Gene ◽  
Binding Protein ◽  
Regulatory Element ◽  
Protein Cleavage ◽  
Response Element ◽  
Androgen Response Element ◽  
Element Binding Protein ◽  
Sterol Regulatory Element ◽  
Direct Regulation

Inhibition of sterol regulatory element-binding protein cleavage by the prodomain of human SKI-1 protease

2000 ◽  
Vol 151 (1) ◽  
pp. 287
Author(s):  
R. Laaksonen ◽  
C. Lefebvre ◽  
J. Lavigne ◽  
E. Priceputu ◽  
L. Bernier ◽  
...  
Keyword(s):  
Binding Protein ◽  
Regulatory Element ◽  
Protein Cleavage ◽  
Element Binding Protein ◽  
Sterol Regulatory Element

scholarly journals The Gene-Gene Interaction of INSIG-SCAP-SREBP Pathway on the Risk of Obesity in Chinese Children

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Fang-Hong Liu ◽  
Jie-Yun Song ◽  
Xiao-Rui Shang ◽  
Xiang-Rui Meng ◽  
Jun Ma ◽  
...  
Keyword(s):  
Genetic Variants ◽  
Protein Gene ◽  
Risk Group ◽  
Binding Protein ◽  
Regulatory Element ◽  
Chinese Children ◽  
Increased Risk ◽  
Element Binding Protein ◽  
Sterol Regulatory Element ◽  
Binding Protein Gene

Background.Childhood obesity has become a global public health problem in recent years. This study aimed to explore the association of genetic variants in INSIG-SCAP-SREBP pathway with obesity in Chinese children.Methods.A case-control study was conducted, including 705 obese cases and 1,325 nonobese controls. We genotyped 15 single nucleotide polymorphisms (SNPs) of five genes in INSIG-SCAP-SREBP pathway, including insulin induced gene 1 (INSIG1), insulin induced gene 2 (INSIG2), SREBP cleavage-activating protein gene (SCAP), sterol regulatory element binding protein gene 1 (SREBP1), and sterol regulatory element binding protein gene 2 (SREBP2). We used generalized multifactor dimensionality reduction (GMDR) and logistic regression to investigate gene-gene interactions.Results.Single polymorphism analyses showed thatSCAPrs12487736 and rs12490383 were nominally associated with obesity. We identified a 3-locus interaction on obesity in GMDR analyses(P=0.001), involving 3 genetic variants ofINSIG2,SCAP,andSREBP2. The individuals in high-risk group of the 3-locus combinations had a 79.9% increased risk of obesity compared with those in low-risk group (OR=1.799, 95% CI: 1.475–2.193,P=6.61×10-9).Conclusion.We identified interaction of three genes in INSIG-SCAP-SREBP pathway on risk of obesity, revealing that these genes affect obesity more likely through a complex interaction pattern than single gene effect.

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