scholarly journals Ascorbic acid insufficiency impairs spatial memory formation in juvenile AKR1A-knockout mice

2019 ◽  
Vol 65 (3) ◽  
pp. 209-216
Author(s):  
Kazuki Kurihara ◽  
Takujiro Homma ◽  
Sho Kobayashi ◽  
Mototada Shichiri ◽  
Hiroki Fujiwara ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Spatial Memory ◽  
Knockout Mice ◽  
Memory Formation

scholarly journals Helios modulates the maturation of a CA1 neuronal subpopulation required for spatial memory formation

2020 ◽  
Vol 323 ◽  
pp. 113095 ◽  
Author(s):  
Albert Giralt ◽  
Verónica Brito ◽  
Monica Pardo ◽  
Sara E. Rubio ◽  
Lucile Marion-Poll ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Memory Formation

Ascorbic acid and CoQ10 ameliorate the reproductive ability of superoxide dismutase 1-deficient female mice†

2019 ◽  
Author(s):  
Naoki Ishii ◽  
Takujiro Homma ◽  
Jaeyong Lee ◽  
Hikaru Mitsuhashi ◽  
Ken-ichi Yamada ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Superoxide Dismutase ◽  
Coenzyme Q10 ◽  
Knockout Mice ◽  
Knockout Mouse ◽  
Superoxide Dismutase 1 ◽  
Wild Type ◽  
Positive Effects ◽  
Reproductive Ability ◽  
Ascorbic Acid Supplementation

Abstract Superoxide dismutase 1 suppresses oxidative stress within cells by decreasing the levels of superoxide anions. A dysfunction of the ovary and/or an aberrant production of sex hormones are suspected causes for infertility in superoxide dismutase 1-knockout mice. We report on attempts to rescue the infertility in female knockout mice by providing two antioxidants, ascorbic acid and/or coenzyme Q10, as supplements in the drinking water of the knockout mice after weaning and on an investigation of their reproductive ability. On the first parturition, 80% of the untreated knockout mice produced smaller litter sizes compared with wild-type mice (average 2.8 vs 7.3 pups/mouse), and supplementing with these antioxidants failed to improve these litter sizes. However, in the second parturition of the knockout mice, the parturition rate was increased from 18% to 44–75% as the result of the administration of antioxidants. While plasma levels of progesterone at 7.5 days of pregnancy were essentially the same between the wild-type and knockout mice and were not changed by the supplementation of these antioxidants, sizes of corpus luteum cells, which were smaller in the knockout mouse ovaries after the first parturition, were significantly ameliorated in the knockout mouse with the administration of the antioxidants. Moreover, the impaired vasculogenesis in uterus/placenta was also improved by ascorbic acid supplementation. We thus conclude that ascorbic acid and/or coenzyme Q10 are involved in maintaining ovarian and uterus/placenta homeostasis against insults that are augmented during pregnancy and that their use might have positive effects in terms of improving female fertility.

scholarly journals Ascorbic Acid Attenuates Acute Ethanol-Induced Liver Injury in SMP30 Knockout Mice

2017 ◽  
Vol 08 (12) ◽  
pp. 1114-1126
Author(s):  
Eun-Mi Cho ◽  
H. M. Arif Ullah ◽  
Ahmed K. Elfadl ◽  
Myung-Jin Chung ◽  
Soong-Koo Kim ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Liver Injury ◽  
Knockout Mice ◽  
Acute Ethanol

Blockade of N-methyl-d-aspartate receptors in the insular cortex disrupts taste aversion and spatial memory formation

Neuroscience ◽  
1999 ◽  
Vol 89 (3) ◽  
pp. 751-758 ◽  
Author(s):  
H Gutiérrez ◽  
E Hernández-Echeagaray ◽  
V Ramı́rez-Amaya ◽  
F Bermúdez-Rattoni
Keyword(s):  
Spatial Memory ◽  
Taste Aversion ◽  
Insular Cortex ◽  
Memory Formation

scholarly journals Spatial memory formation requires netrin-1 expression by neurons in the adult mammalian brain

2019 ◽  
Vol 26 (3) ◽  
pp. 77-83 ◽  
Author(s):  
Edwin W. Wong ◽  
Stephen D. Glasgow ◽  
Lianne J. Trigiani ◽  
Daryan Chitsaz ◽  
Vladimir Rymar ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Memory Formation ◽  
Mammalian Brain ◽  
Adult Mammalian Brain

scholarly journals Decrease of Rab11 prevents the correct dendritic arborization, synaptic plasticity and spatial memory formation

2020 ◽  
Vol 1867 (9) ◽  
pp. 118735 ◽  
Author(s):  
Sebastian O. Siri ◽  
Victoria Rozés-Salvador ◽  
Emilce Artur de la Villarmois ◽  
Marisa S. Ghersi ◽  
Gonzalo Quassollo ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Spatial Memory ◽  
Memory Formation ◽  
Dendritic Arborization
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