scholarly journals Improvement of Glucose Metabolism in Patients with Impaired Glucose Tolerance or Diabetes by Long-Term Administration of a Palatinose-Based Liquid Formula as a Part of Breakfast

2009 ◽  
Vol 45 (2) ◽  
pp. 155-162 ◽  
Author(s):  
Masae Sakuma ◽  
Hidekazu Arai ◽  
Akira Mizuno ◽  
Makiko Fukaya ◽  
Motoi Matsuura ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Term Administration

Long-Term Effects of Combined Chelation Therapy on Glucose Metabolism of Thalassemic Patients.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 2770-2770
Author(s):  
Kalistheni Farmaki ◽  
Nicholas Angelopoulos ◽  
Vasilios Berdoukas ◽  
Ioanna Tsoumari ◽  
Christina Pappa ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Glucose Metabolism ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Chelation Therapy ◽  
Fasting Glucose ◽  
Long Term Effects ◽  
Glucose Response

Abstract • The incidence of impaired glucose tolerance and diabetes in thalassemiamajor patients varied from 9% to 15%, depending on the age of assessment and intensity (and compliance) of chelation and transfusion. It is uncertain whether early assessment and tailored chelation can prevent diabetes and preserve pancreatic reserve. There are now reports of endocrine improvements with intense chelation in regards to glucose metabolism which are limited to 3 years of follow up. However, whether the pancreas may regenerate or remodel even with reduction in hemosiderosis is unknown and questions have arisen whether these are lasting improvements reflecting an overtime advantage earned by the intensification of chelation. The aim was to determine the long-term effects of combined chelation therapy on glucose metabolism in beta-thalassaemic patients • From January 2001 to October 2003, 42 thalassemic patients (initially treated with deferoxamine DFO monotherapy) were gradually switched to an individually tailored combined regimen with DFO and deferiprone. Glucose metabolism characteristics were evaluated by Oral glucose tolerance test (OGTT). Each patient was assessed separately before initiating combined therapy, and all patients were thereafter yearly reassessed (June 2005, June 2006 and June 2007). Full biochemical data (4 consecutive measurements) were available in 30 patients (3 got pregnant during this period, 5 denied repeated OGTT and 4 patients with severe and sustained hyperglycaemia started antidiabetic drugs after the second assessment in 2006). Insulin sensitivity and beta-cell function were assessed by calculated indices, using the most widely applied insulin sensitivity index - the homeostasis assessment model (ISI HOMA) which is based on fasting glucose and insulin alone. The area under the curve (AUC) was also calculated for estimating integrated response during OGTT for both glucose and insulin. Significant variations over time for each parameter were examined with ANOVA (general linear model) for repeated measurements. Ferritin levels were significantly decreased (P<0.01),AUCglu decreased (P=0.002)and SCHoma increased (P=0.004) as illustrated in Table 1. 70% of patients had abnormal glucose response during the first OGTT (diabetic response, Impaired glucose tolerance or impaired fasting glucose, according to the latest criteria of the American Diabetes Association published in September 2005). In May 2007, only 20% exhibited abnormal glucose response with the same provocative test (P<0.001,non-parametric McNemar test). Our 6-year follow-up demonstrates that use of combined chelation therapy continues to be of benefit in terms of glucose metabolism in thalassemic patients. Parameters (Mean value) 1st assessment 2005 2006 2007 Ferritin 2960 551 585 629 SCHoma 133.4 215.6 200.6 209.9 ISI Homa 1.101 0.964 1.085 0.886 AUCglucose 18217 16166 16526 15655

Long-term administration of PACAP receptor antagonist, PACAP(6-27), impairs glucose tolerance and insulin sensitivity in obese diabetic ob/ob mice

Peptides ◽  
2006 ◽  
Vol 27 (9) ◽  
pp. 2343-2349 ◽  
Author(s):  
Brian D. Green ◽  
Nigel Irwin ◽  
Roslyn S. Cassidy ◽  
Victor A. Gault ◽  
Peter R. Flatt
Keyword(s):  
Insulin Sensitivity ◽  
Glucose Tolerance ◽  
Receptor Antagonist ◽  
Term Administration

scholarly journals Adult offspring of high-fat diet-fed dams can have normal glucose tolerance and body composition

2014 ◽  
Vol 5 (3) ◽  
pp. 229-239 ◽  
Author(s):  
K. M. Platt ◽  
R. J. Charnigo ◽  
K. J. Pearson
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
High Fat Diet ◽  
High Fat ◽  
High Fat Diets ◽  
Normal Glucose ◽  
Fat Diets

Maternal high-fat diet consumption and obesity have been shown to program long-term obesity and lead to impaired glucose tolerance in offspring. Many rodent studies, however, use non-purified, cereal-based diets as the control for purified high-fat diets. In this study, primiparous ICR mice were fed purified control diet (10–11 kcal% from fat of lard or butter origin) and lard (45 or 60 kcal% fat) or butter (32 or 60 kcal% fat)-based high-fat diets for 4 weeks before mating, throughout pregnancy, and for 2 weeks of nursing. Before mating, female mice fed the 32 and 60% butter-based high-fat diets exhibited impaired glucose tolerance but those females fed the lard-based diets showed normal glucose disposal following a glucose challenge. High-fat diet consumption by female mice of all groups decreased lean to fat mass ratios during the 4th week of diet treatment compared with those mice consuming the 10–11% fat diets. All females were bred to male mice and pregnancy and offspring outcomes were monitored. The body weight of pups born to 45% lard-fed dams was significantly increased before weaning, but only female offspring born to 32% butter-fed dams exhibited long-term body weight increases. Offspring glucose tolerance and body composition were measured for at least 1 year. Minimal, if any, differences were observed in the offspring parameters. These results suggest that many variables should be considered when designing future high-fat diet feeding and maternal obesity studies in mice.

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