Long-term administration of acetylsalicylic acid in impaired glucose tolerance in addition to the diet: Effects and limits

1981 ◽  
Vol 18 (3) ◽  
pp. 225-233 ◽  
Author(s):  
Francesco Caviezel ◽  
Anna Giulia Cattaneo ◽  
Guido Pozza
Keyword(s):  
Glucose Tolerance ◽  
Acetylsalicylic Acid ◽  
Impaired Glucose Tolerance ◽  
Term Administration

Long-term administration of PACAP receptor antagonist, PACAP(6-27), impairs glucose tolerance and insulin sensitivity in obese diabetic ob/ob mice

Peptides ◽  
2006 ◽  
Vol 27 (9) ◽  
pp. 2343-2349 ◽  
Author(s):  
Brian D. Green ◽  
Nigel Irwin ◽  
Roslyn S. Cassidy ◽  
Victor A. Gault ◽  
Peter R. Flatt
Keyword(s):  
Insulin Sensitivity ◽  
Glucose Tolerance ◽  
Receptor Antagonist ◽  
Term Administration

scholarly journals Adult offspring of high-fat diet-fed dams can have normal glucose tolerance and body composition

2014 ◽  
Vol 5 (3) ◽  
pp. 229-239 ◽  
Author(s):  
K. M. Platt ◽  
R. J. Charnigo ◽  
K. J. Pearson
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
High Fat Diet ◽  
High Fat ◽  
High Fat Diets ◽  
Normal Glucose ◽  
Fat Diets

Maternal high-fat diet consumption and obesity have been shown to program long-term obesity and lead to impaired glucose tolerance in offspring. Many rodent studies, however, use non-purified, cereal-based diets as the control for purified high-fat diets. In this study, primiparous ICR mice were fed purified control diet (10–11 kcal% from fat of lard or butter origin) and lard (45 or 60 kcal% fat) or butter (32 or 60 kcal% fat)-based high-fat diets for 4 weeks before mating, throughout pregnancy, and for 2 weeks of nursing. Before mating, female mice fed the 32 and 60% butter-based high-fat diets exhibited impaired glucose tolerance but those females fed the lard-based diets showed normal glucose disposal following a glucose challenge. High-fat diet consumption by female mice of all groups decreased lean to fat mass ratios during the 4th week of diet treatment compared with those mice consuming the 10–11% fat diets. All females were bred to male mice and pregnancy and offspring outcomes were monitored. The body weight of pups born to 45% lard-fed dams was significantly increased before weaning, but only female offspring born to 32% butter-fed dams exhibited long-term body weight increases. Offspring glucose tolerance and body composition were measured for at least 1 year. Minimal, if any, differences were observed in the offspring parameters. These results suggest that many variables should be considered when designing future high-fat diet feeding and maternal obesity studies in mice.

Impaired glucose tolerance: do pharmacological therapies correct the underlying metabolic disturbance?

2003 ◽  
Vol 3 (1_suppl) ◽  
pp. S24-S40 ◽  
Author(s):  
Ralph A Defronzo
Keyword(s):  
Type 2 Diabetes ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Beta Cell Function ◽  
Diabetes Prevention ◽  
Cell Function ◽  
Pharmacologic Therapy ◽  
Exercise Regimen

Lifestyle intervention prevents or delays the conversion from impaired glucose tolerance (IGT) to type 2 diabetes. However, many subjects fail to achieve and/or maintain long-term weight loss and to follow a regular exercise regimen may require pharmacologic therapy. Insulin resistance in liver, muscle and fat, along with impaired beta-cell function, plays a central role in the pathogenesis of type 2 diabetes. Insulin sensitising drugs, including metformin and the thiazolidinediones, have significantly reduced the conversion rate of IGT to type 2 diabetes in subjects in several large, well designed clinical trials. Insulin-sensitising drugs are likely to play an important role in future strategies for diabetes prevention.

Long-term administration of maxadilan improves glucose tolerance and insulin sensitivity in mice

Peptides ◽  
2008 ◽  
Vol 29 (8) ◽  
pp. 1347-1353 ◽  
Author(s):  
Rongjie Yu ◽  
Tianhong Yi ◽  
Shanshan Xie ◽  
An Hong
Keyword(s):  
Insulin Sensitivity ◽  
Glucose Tolerance ◽  
Term Administration
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