scholarly journals Spontaneous chordoma: a case report on a female UM-HET3 mouse from the SLAM study

2020 ◽  
Vol 2 (4) ◽  
pp. 219-222
Author(s):  
Eleonora Duregon ◽  
◽  
Camila Vieira Ligo Teixeira ◽  
Rafael de Cabo
Keyword(s):  
Spinal Cord ◽  
Case Report ◽  
Clinical Finding ◽  
Hind Limb ◽  
Histological Analysis ◽  
Tumor Burden ◽  
Limb Weakness ◽  
Intervertebral Disks ◽  
Spontaneous Neoplasm

A female UM-HET3 mouse from the Study of Longitudinal Aging in Mice (SLAM) was euthanized at 164 weeks of age due to hind limb weakness. Necropsy and histological analysis revealed that the most probable cause of the clinical finding was the compression of the thoracolumbar segment of the spinal cord by herniated intervertebral disks. In addition, a spontaneous chordoma was incidentally found in the coccygeal bones. Given the rarity of this type of tumor, bio-clinical annotations acquired throughout lifespan, detailed histopathological assessment, and comparative clinical-pathological correlations for this mouse are presented and discussed. Keywords: Geropathology, geroscience, study of longitudinal aging in mice (SLAM), spontaneous neoplasm, tumor burden, chordoma

scholarly journals Metastatic epidural spinal cord compression

2020 ◽  
Vol 2020 (8) ◽  
Author(s):  
Preci Hamilton ◽  
Peyton Lawrence ◽  
Christian Valentin Eisenring
Keyword(s):  
Spinal Cord ◽  
Stereotactic Radiosurgery ◽  
Spinal Cord Compression ◽  
Scoring Systems ◽  
Cord Compression ◽  
Tumor Burden ◽  
Pedicle Screw Fixation ◽  
Limb Weakness ◽  
Neoplastic Lesion ◽  
Spinal Sagittal Alignment

Abstract Up-to-date management for metastatic epidural spinal cord compression is based on appropriate scoring systems. In this case, separation surgery and stereotactic radiosurgery achieved an optimized outcome. A 75-year-old man had thoracic band-like pain, left lower limb weakness and difficulty ambulating for 6 weeks. Spinal images showed a T4 metastatic epidural spinal cord compression with a pathological fracture of T4 and T10 and L3 lytic lesions. There was no other neoplastic lesion. The metastasized T4 was decompressed by a posterolateral right costotransversectomy, vertebrectomy and insertion of an expandable titanium cage. The spinal sagittal alignment was restored with T1–T7 pedicle screw fixation. Post-operatively the pain and motor power improved significantly so that the patient was discharged home. Separation surgery and adjuvant stereotactic radiosurgery of the spine successfully improved tumor burden, pain control and overall prognosis.

Intramedullary Clear Cell Ependymoma in the Cervical Spinal Cord: Case Report

Neurosurgery ◽  
2000 ◽  
Vol 47 (6) ◽  
pp. 1434-1434 ◽  
Author(s):  
Hiroyoshi Akutsu ◽  
Yasushi Shibata ◽  
Masao Okazaki ◽  
Akio Hyodo ◽  
Akira Matsumura
Keyword(s):  
Spinal Cord ◽  
Case Report ◽  
Histological Analysis ◽  
Clinical Presentation ◽  
Clear Cell ◽  
Cervical Spinal Cord ◽  
Intramedullary Tumor ◽  
Intramedullary Spinal Cord ◽  
First Case ◽  
Clear Cell Ependymoma

ABSTRACT OBJECTIVE AND IMPORTANCE Clear cell ependymoma of the spinal cord has not been reported in the literature, although ependymoma in the cerebral and cerebellar hemispheres has been described. We present the first case report of this rare histological type of ependymoma arising in the cervical spinal cord and emphasize the importance of recognizing this histological entity. CLINICAL PRESENTATION A 42-year-old woman presented with numbness in both upper limbs and spastic gait. Magnetic resonance imaging revealed an intramedullary tumor at the C6–T1 level with syringomyelia. INTERVENTION The tumor was totally removed. Histological analysis revealed that the tumor was composed of round cells with perinuclear halos similar to those observed in oligodendroglioma. However, we diagnosed clear cell ependymoma because these tumor cells exhibited epithelial features and ependymal rosettes under light microscopic examination. CONCLUSION Histological diagnosis was crucial to our determining whether to perform postoperative adjuvant therapy in this patient. Neurosurgeons should be aware of the possibility of this histological entity among intramedullary spinal cord tumors.

scholarly journals Multilobed Supernumerary Teeth with Talon: Pioneer Case Report

2008 ◽  
Vol 2 (1) ◽  
pp. 13-15 ◽  
Author(s):  
Mahesh Goel ◽  
Samir Dutta ◽  
Rosy Arora
Keyword(s):  
Case Report ◽  
Clinical Finding ◽  
Rare Case ◽  
Histological Analysis ◽  
Supernumerary Teeth ◽  
Supernumerary Tooth ◽  
Rare Case Report

ABSTRACT A rare case report of a multi-lobed supernumerary tooth having talon cusp is being reported. The tooth was extracted to correct the existing malocclusion and a complete radiographic and histological analysis of the extracted tooth was done to confirm the clinical finding of supernumerary tooth with incomplete lobes associated with talon cusp exhibiting pulpal extension.

Spontaneous Herniation of the Thoracic Spinal Cord: A Case Report

2001 ◽  
Vol 45 (4) ◽  
pp. 353 ◽  
Author(s):  
Sung Chan Jin ◽  
Seoung Ro Lee ◽  
Dong Woo Park ◽  
Kyung Bin Joo
Keyword(s):  
Spinal Cord ◽  
Case Report ◽  
Thoracic Spinal Cord ◽  
Thoracic Spinal ◽  
Spontaneous Herniation

Odontoid cervical gout causing atlantoaxial instability: case report

2019 ◽  
Vol 30 (4) ◽  
pp. 541-544
Author(s):  
Justin Slavin ◽  
Marcello DiStasio ◽  
Paul F. Dellaripa ◽  
Michael Groff
Keyword(s):  
Rheumatoid Arthritis ◽  
Spinal Cord ◽  
Case Report ◽  
Physical Examination ◽  
Odontoid Process ◽  
Signs And Symptoms ◽  
Cord Compression ◽  
Atlantoaxial Instability ◽  
Posterior Stabilization ◽  
Rotatory Subluxation

The authors present a case report of a patient discovered to have a rotatory subluxation of the C1–2 joint and a large retroodontoid pannus with an enhancing lesion in the odontoid process eventually proving to be caused by gout. This patient represented a diagnostic conundrum as she had known prior diagnoses of not only gout but also sarcoidosis and possible rheumatoid arthritis, and was in the demographic range where concern for an oncological process cannot fully be ruled out. Because she presented with signs and symptoms of atlantoaxial instability, she required posterior stabilization to reduce the rotatory subluxation and to stabilize the C1–2 instability. However, despite the presence of a large retroodontoid pannus, she had no evidence of spinal cord compression on physical examination or imaging and did not require an anterior procedure to decompress the pannus. To confirm the diagnosis but avoid additional procedures and morbidity, the authors proceeded with the fusion as well as a posterior biopsy to the retroodontoid pannus and confirmed a diagnosis of gout.

Atypical pilocytic astrocytoma of adult spinal cord: A case report

2018 ◽  
pp. 1-2
Keyword(s):  
Spinal Cord ◽  
Young Adults ◽  
Case Report ◽  
Pilocytic Astrocytoma ◽  
Treatment Protocol ◽  
Pilomyxoid Astrocytoma ◽  
Standardized Treatment ◽  
Children And Young Adults ◽  
Adult Spinal Cord

Pilomyxoid astrocytoma (PMA) is an atypical subtype of pilocytic astrocytoma (PA), which presents in children and young adults. The incidence of PMA is low, so there is no standardized treatment protocol for it. Here, we present a 62-year-old woman with recurrent PMA, which is important for the understanding and treatment of the disease.

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