Synchronous Bilateral Solid Papillary Carcinoma of Breast: A Rare Case Report

2020 ◽  
pp. 1-3
Author(s):  
Ayşe Nur Uğur Kılınç ◽  
Ayşe Nur Uğur Kılınç ◽  
Zeynep Bayramoğlu ◽  
Yaşar Ünlü ◽  
Nergis Aksoy ◽  
...  

Background: Solid papillary carcinoma is a rare type of carcinoma that accounts for less than 1% of all breast cancers and mostly seen in postmenopausal women. This report presents a rare case of synchronous bilateral solid papillary carcinoma of the breast. Case Report: A 74-year-old female patient had a mass in her right and left breast. Bilateral total mastectomy and sentinel lymph node biopsy were performed. The pathologic diagnosis was synchronous bilateral solid papillary carcinoma. No lymph node metastasis was detected in either of the breasts. Conclusion: To our knowledge, little is known about simultaneous bilateral solid papillary carcinomas. Solid papillary carcinoma should be kept in mind in the differential diagnosis of bilateral breast masses with neuroendocrine differentiation in elderly patients.

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Xue Lin ◽  
Yoshiaki Matsumoto ◽  
Tomomi Nakakimura ◽  
Kazuo Ono ◽  
Shigeaki Umeoka ◽  
...  

2021 ◽  
Author(s):  
Zhaorui Wang ◽  
Jingjing Wang ◽  
Yubo Pan ◽  
Jing Pei

Abstract Introduction: Encapsulated papillary carcinoma (EPC)of the breast is a rare type of breast cancer with excellent prognosis. It is usually considered a variant of ductal carcinoma in situ (DCIS). However, no consensus on EPC treatment and management has been achieved. We provide some data from our clinical centers to help better manage this disease.Methods: We performed a retrospective analysis of patients diagnosed with EPC from March 2015 to December 2019 at The First Affiliated Hospital of Anhui Medical University. Demographic information, tumor details, immunohistochemical markers, clinical data, stage of the disease, treatment modalities, and oncological outcomes were collected.Results: Eleven cases were included in this retrospective study: three cases had pure EPC, six cases had EPC associated with DCIS, and two cases had EPC associated with invasive cancer. Among the patients, two had lymph node metastases. The mean age of female patients at diagnosis was 53.6 years. The one male patient was 48 years old. The mean tumor size was 2.4 cm. Myoepithelial cell layers were completely absent in all cases. Ten patients were estrogen receptor and progesterone receptor positive and human epidermal growth factor receptor-2 negative. Nine patients underwent mastectomy, and two underwent breast-conserving surgery.Conclusion: Adequate local therapy results in excellent prognosis. Radiation therapy should be offered to patients with EPC who undergo breast-conserving surgery. Immunohistochemistry is necessary in diagnosing EPC and excluding other papillary lesions. Excisional biopsy should be performed to achieve comprehensive diagnosis. Sentinel lymph node biopsy is recommended for patients with EPC.


2017 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Arzu Ozsoy ◽  
Nurdan Barca ◽  
Betul Akdal ◽  
Serra Kayacetin ◽  
Levent Araz

2011 ◽  
Vol 20 (1) ◽  
pp. 97-100
Author(s):  
Cunxian Zhang ◽  
M. Ruhul Quddus ◽  
C. James Sung ◽  
Richard G. Moore ◽  
W. Dwayne Lawrence

2016 ◽  
Vol 4 (12) ◽  
pp. 1301-1305
Author(s):  
Dr.Amreen Brown ◽  
◽  
Dr.Parul Gupta ◽  
Dr.Shruti Singh ◽  
Dr.Nirupma Lal ◽  
...  

2018 ◽  
Vol 26 (6) ◽  
pp. 573-577 ◽  
Author(s):  
Hideharu Domoto ◽  
Akiko Watanabe ◽  
Michio Sakata ◽  
Akihiko Shimada ◽  
Kiyoshi Mukai

We report a case of invasive solid papillary carcinoma (SPC) of the nipple with Pagetoid extension to the skin and lymph node metastasis. SPC is an uncommon primary breast cancer accounting for less than 1% of all breast cancers. Only 2 cases occurring in the nipple have been reported. However, both cases were without Pagetoid extension or lymph node metastasis. The presently reported tumor consisted of irregularly shaped solid cell nests with delicate fibrovascular cores. The tumor cells had round nuclei with low-grade atypia and eosinophilic cytoplasm. Neuroendocrine differentiation was confirmed by immunohistochemical positivity for CD56, synaptophysin, and chromogranin A. Immunohistochemistry also confirmed the absence of myoepithelial cells around the tumor cell nests. Therefore, a diagnosis of invasive SPC was made. Additionally, tumor cell deposits in the intramammary and axillary lymph nodes were identified, and these deposits had the same histological characteristics as the invasive SPC of the nipple. The invasiveness of SPC can be difficult to determine. However, the tumor cell nests in the current case exhibited a retraction artifact, which is known to be associated with invasive carcinoma and a poor prognosis, as well as morphological patterns that have been previously identified as characteristic of invasive SPC. Although SPC is widely recognized as having a favorable outcome, the existence of exceptionally aggressive cases occurring in the nipple must be recognized. Additional cases of invasive SPC of the nipple are needed to analyze the clinicopathological correlation.


We report a very rare case of squamous cell cancer of the right foot which had metastasize to the ipsilateral popliteal lymph node after initial diagnosis and treatment for the loco-regional disease.


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