scholarly journals A MEMS-BASED RENAL REPLACEMENT SYSTEM

2004 ◽  
Author(s):  
J.T. Borenstein ◽  
M. Kaazempur-Mofrad ◽  
N. Krebs ◽  
J. Vacanti
Keyword(s):  
Replacement System

scholarly journals Phenotypic characterization of missense polymerase-δ mutations using an inducible protein-replacement system

2014 ◽  
Vol 5 (1) ◽  
Author(s):  
Medini Manohar Ghodgaonkar ◽  
Patrick Kehl ◽  
Ilenia Ventura ◽  
Liyan Hu ◽  
Margherita Bignami ◽  
...  
Keyword(s):  
Phenotypic Characterization ◽  
Replacement System ◽  
Inducible Protein

Complications with the Zurich Canine Total Hip Replacement System in an Initial Series of Cases Performed by a Single Surgeon

2021 ◽  
Author(s):  
Samuel P. Franklin ◽  
Nathan A. Miller ◽  
Todd Riecks
Keyword(s):  
Total Hip Replacement ◽  
Hip Replacement ◽  
Weight Bearing ◽  
Normal Function ◽  
High Rate ◽  
Total Hip ◽  
Initial Series ◽  
Major Complications ◽  
Hip Replacements ◽  
Replacement System

Abstract Objective The aim of this study was to quantify the complications using the Zurich total hip replacement system in an initial series of cases performed by a single surgeon who had experience with other total hip replacement systems. Materials and Methods This was a retrospective study in which complications were classified as major if any treatment was needed or if the outcome was less than near-normal function. Complications that did not warrant treatment and that did not result in function that was inferior to near-normal were considered minor. Outcomes were assessed by radiographic review, physical examination, subjective gait evaluation or, in one case, by objective gait analysis. Bilateral total hip replacements were considered separate procedures. Results The first 21 procedures in 19 dogs performed by a single surgeon were included. The mean time to follow-up was 48 weeks (range: 8–120 weeks; standard deviation: 36 weeks). Two cases (of 21) experienced major complications including one dog with excess internal femoral rotation during weight bearing and one dog having luxation. One case (of 21) had a minor complication; femoral fracture in the presence of an intact bone plate that maintained alignment and healed without treatment. Clinical Significance A high rate of successful outcomes with few major complications can be obtained in the initial cases treated using the Zurich total hip replacement system for surgeons with prior experience with other total hip replacement systems.

A targeted-replacement system for identification of signals for de novo methylation in Neurospora crassa

1994 ◽  
Vol 14 (11) ◽  
pp. 7059-7067
Author(s):  
V P Miao ◽  
M J Singer ◽  
M R Rountree ◽  
E U Selker
Keyword(s):  
Dna Methylation ◽  
Neurospora Crassa ◽  
De Novo ◽  
Gene Replacement ◽  
Position Effects ◽  
Efficient Gene ◽  
Bona Fide ◽  
Replacement System ◽  
Methylation Signal ◽  
De Novo Methylation

Transformation of eukaryotic cells can be used to test potential signals for DNA methylation. This approach is not always reliable, however, because of chromosomal position effects and because integration of multiple and/or rearranged copies of transforming DNA can influence DNA methylation. We developed a robust system to evaluate the potential of DNA fragments to function as signals for de novo methylation in Neurospora crassa. The requirements of the system were (i) a location in the N. crassa genome that becomes methylated only in the presence of a bona fide methylation signal and (ii) an efficient gene replacement protocol. We report here that the am locus fulfills these requirements, and we demonstrate its utility with the identification of a 2.7-kb fragment from the psi 63 locus as a new portable signal for de novo methylation.

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