Synthesis and study of structural, morphological, optical and toxicological properties of ferromagnetic cobalt oxide nanoparticles in liver carcinoma cell line

Author(s):  
Seemab Iqbal ◽  
Muhammad Fakhar-e-Alam ◽  
N. Amin ◽  
M. Ismail ◽  
G. Mustafa ◽  
...  
Cell Research ◽  
1993 ◽  
Vol 3 (1) ◽  
pp. 75-83 ◽  
Author(s):  
Yonghua Xu ◽  
Wanli Jiang ◽  
Sufeng Peng ◽  
Yinghua Chen

2009 ◽  
Vol 72 (4) ◽  
pp. 616-627 ◽  
Author(s):  
Sérgio Mota ◽  
Marta Mendes ◽  
Natália Freitas ◽  
Deborah Penque ◽  
Ana V. Coelho ◽  
...  

Marine Drugs ◽  
2019 ◽  
Vol 17 (5) ◽  
pp. 294 ◽  
Author(s):  
Rui-Jun Wang ◽  
Shao-Yong Zhang ◽  
Yang-Hui Ye ◽  
Zhen Yu ◽  
Huan Qi ◽  
...  

The mangrove ecosystem is a rich resource for the discovery of actinomycetes with potential applications in pharmaceutical science. Besides the genus Streptomyces, Micromonospora is also a source of new bioactive agents. We screened Micromonospora from the rhizosphere soil of mangrove plants in Fujian province, China, and 51 strains were obtained. Among them, the extracts of 12 isolates inhibited the growth of human lung carcinoma A549 cells. Strain 110B exhibited better cytotoxic activity, and its bioactive constituents were investigated. Consequently, three new isoflavonoid glycosides, daidzein-4′-(2-deoxy-α-l-fucopyranoside) (1), daidzein-7-(2-deoxy-α-l-fucopyranoside) (2), and daidzein-4′,7-di-(2-deoxy-α-l-fucopyranoside) (3) were isolated from the fermentation broth of strain 110B. The structures of the new compounds were determined by spectroscopic methods, including 1D and 2D nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HR-ESIMS). The result of medium-changing experiments implicated that these new compounds were microbial biotransformation products of strain M. aurantiaca 110B. The three compounds displayed moderate cytotoxic activity to the human lung carcinoma cell line A549, hepatocellular liver carcinoma cell line HepG2, and the human colon tumor cell line HCT116, whereas none of them showed antifungal or antibacterial activities.


2018 ◽  
Vol 118 ◽  
pp. 1763-1772 ◽  
Author(s):  
Mina Nouri ◽  
Narges Esfahanizadeh ◽  
Mahsa Ghofrani Shahpar ◽  
Farnoosh Attar ◽  
Nasrin Sartipnia ◽  
...  

2017 ◽  
Vol 4 (S) ◽  
pp. 86
Author(s):  
John Paul Tosoc

C. olitorius are used as herbal medicine and eaten as vegetable by local people in Philippines.  The T’boli tribe commonly uses this plant to treat common illnesses such as pimples, wounds, boils, and inflammations. According to studies, the leaves of C. olitorius has properties to treat demulcent, diuretic, febrifuge, chronic cystitis, dysuria and even tumor. The aim of this study is to evaluate the cytotoxicity properties of the crude aqueous extract of C. olitorius leaf against colon (HCT116), breast (MCF-7), and liver (HepG2) carcinoma cell-lines using the MTT cell proliferation assay. The results showed that the aqueous extract has potential cytotoxicity activity against the three-carcinoma cell-lines. The aqueous extract was most bioactive in the colon carcinoma cell-line (HCT116) with cell viability percentage of 23.53 and 32.48 in 100 and 10 µg/mL, respectively. It was then followed by the breast carcinoma cell-line (MCF7) with cell viability percentage of 16.23 and 30.25 in 100 and 10 µg/mL, respectively. The extract was least but still bioactive in the liver carcinoma cell-line (HepG2) with cell viability percentage of 91.20 and 132.76 in 100 and 10 µg/mL, respectively. This study illustrates the importance of toxicological screening to confirm the safety and efficacy of the medicinal plant commonly used in the traditional medicine system in the treatment and management of illnesses by the T’boli tribe in South Cotabato


2003 ◽  
Vol 46 (16) ◽  
pp. 3502-3507 ◽  
Author(s):  
Junyong Zhang ◽  
Xiaoyong Wang ◽  
Chao Tu ◽  
Jun Lin ◽  
Jian Ding ◽  
...  

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