scholarly journals Effects of Food Proteins and Peptides on Immunoglobulin Production in Mouse Spleen Lymphocytes.

2003 ◽  
Vol 50 (2) ◽  
pp. 72-77 ◽  
Author(s):  
Takeaki Okamoto ◽  
Kazuma Yoshimi ◽  
Hirofumi Tachibana ◽  
Koji Yamada
Keyword(s):  
Mouse Spleen ◽  
Food Proteins ◽  
Immunoglobulin Production ◽  
Spleen Lymphocytes ◽  
Proteins And Peptides

scholarly journals Oxidative Stress by Visible Light Irradiation Suppresses Immunoglobulin Production in Mouse Spleen Lymphocytes

2001 ◽  
Vol 65 (3) ◽  
pp. 593-598 ◽  
Author(s):  
Yoshiyuki MIYAZAKI ◽  
Masao YAMASAKI ◽  
Hiroko MISHIMA ◽  
Keiko MANSHO ◽  
Hirofumi TACHIBANA ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Visible Light ◽  
Visible Light Irradiation ◽  
Light Irradiation ◽  
Mouse Spleen ◽  
Immunoglobulin Production ◽  
Spleen Lymphocytes

UVC-induced damage in mouse spleen lymphocytes and anti-radiation effect of exogenous nucleotides

2014 ◽  
Author(s):  
Cuilin Cheng ◽  
Zhenyu Wang ◽  
Haitian Zhao ◽  
Aiju Hou ◽  
Rongchun Wang ◽  
...  
Keyword(s):  
Radiation Effect ◽  
Mouse Spleen ◽  
Spleen Lymphocytes

Density Gradient Electrophoresis of Mouse Spleen Lymphocytes

1980 ◽  
Vol 63 (3) ◽  
pp. 258-265 ◽  
Author(s):  
C.D. Platsoucas ◽  
S.G. Robbins ◽  
N. Catsimpoolas
Keyword(s):  
Density Gradient ◽  
Mouse Spleen ◽  
Gradient Electrophoresis ◽  
Spleen Lymphocytes

scholarly journals Food Proteins and Peptides

2015 ◽  
pp. 309-357 ◽  
Author(s):  
Roberto Samperi ◽  
Anna Laura Capriotti ◽  
Chiara Cavaliere ◽  
Valentina Colapicchioni ◽  
Riccardo Zenezini Chiozzi ◽  
...  
Keyword(s):  
Food Proteins ◽  
Proteins And Peptides

Inhibition of proliferative responses of mouse spleen lymphocytes and rabbit Peyer's patch cells by bovine milk caseins and their digests

1995 ◽  
Vol 62 (2) ◽  
pp. 339-348 ◽  
Author(s):  
Hajime Otani ◽  
Isao Hata
Keyword(s):  
Colorimetric Assay ◽  
Bovine Milk ◽  
Inhibitory Effect ◽  
Mouse Spleen ◽  
Pokeweed Mitogen ◽  
Peyer’S Patch ◽  
Peyer's Patch ◽  
Diphenyltetrazolium Bromide ◽  
Spleen Lymphocytes ◽  
Milk Casein

SUMMARYThe modulating effect of bovine milk casein components and their digests on the proliferative responses of mouse spleen lymphocytes and rabbit Peyer's patch cells induced or not induced by mitogens has been studied with a colorimetric assay using 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide. All the casein components and their digests tested had little mitogenic effect on the proliferative responses of mouse spleen lymphocytes and rabbit Peyer's patch cells. Intact κ-casein significantly inhibited the proliferative responses of mouse spleen lymphocytes and Peyer's patch cells induced by mitogens such as lipopolysaccharide fromSalmonella typhimurium, concanavalin A, phytohaemagglutinin and pokeweed mitogen. In contrast, intact αsl-casein and β-casein had little effect. κ-Casein had an inhibitory effect after digesti on by pancreatin or trypsin, but not after pepsin or chymotrypsin digestion. Both pancreatin and trypsin digests of αsl-casein and -casein significantly inhibited the proliferative responses of mouse spleen lymphocytes and rabbit Peyer's patch cells induced by mitogens, whereas pepsin and chymotrypsin digests of both caseins were without effect. Moreover, the trypsin digest of each casein component had an inhibitory effect on mouse spleen lymphocyte proliferation in the absence of mitogen. Since trypsin is a major proteinase in pancreatin, the substrate specificity of trypsin seems to be important for the formation of the inhibitory peptides from casein components. These observations suggest that intact κ-casein and some peptides formed from milk casein components by the action of trypsin may suppress the immune responsiveness of neonates.

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