A rapid and sensitive method for simultaneous quantification of seven furfural compounds in milk powder based on GC-MS/MS combined with QuEChERS method

2021 ◽  
Vol 27 (4) ◽  
pp. 671-679
Author(s):  
Qiong Wu ◽  
Xiaomei Shi ◽  
Dandan Ren ◽  
Shuya Wang ◽  
Haijin Liu ◽  
...  
Keyword(s):  
Milk Powder ◽  
Quechers Method ◽  
Simultaneous Quantification ◽  
Sensitive Method

Highly sensitive method for aldehydes detection: Application to furfurals analysis in raisin and bovine milk powder

2017 ◽  
Vol 987 ◽  
pp. 47-55 ◽  
Author(s):  
Yao Sun ◽  
Zhaobing Guan ◽  
Hongwei Cai ◽  
Yiyong Huang ◽  
Yawei Lin ◽  
...  
Keyword(s):  
Bovine Milk ◽  
Milk Powder ◽  
Highly Sensitive ◽  
Sensitive Method

Development and Validation of a Procedure for Determination of Sulfonamide Residues in Pasteurized Milk Using Modified QuEChERS Method and Liquid Chromatography/Tandem Mass Spectrometry

2012 ◽  
Vol 95 (5) ◽  
pp. 1528-1533 ◽  
Author(s):  
Swati Ramkrishna Parab ◽  
Priti Nilesh Amritkar
Keyword(s):  
Matrix Effects ◽  
Milk Powder ◽  
The European Union ◽  
Quechers Method ◽  
High Fat ◽  
Pasteurized Milk ◽  
Modified Quechers ◽  
Liquid Chromatography Tandem Mass ◽  
Sulfonamide Residues

Abstract An LC method for determination of 10 sulfonamides in milk using a modified Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) method was developed. Unlike the standard QuEChERS method, addition of primary secondary amine was not required for the cleanup step. Sulfonamides were analyzed from the acetonitrile layer using LC/MS/MS with electrospray ionization. Sulfonamides studied included sulfanilamide, sulfadiazine, sulfathiazole, sulfamerazine, sulfamethiazole, sulfamethazine, sulfamethoxypyridazine, sulfamethoxazole, sulfadoxin, and sulfamethoxine. Three types of milk matrixes, namely, low- and high-fat liquid pasteurized milk and milk powder, were used in the study. Matrix effects of all three matrixes were studied. The LOQs for the 10 analytes for high-fat milk were 5.3–11.2 μg/L. The combined LOQ of the 10 sulfonamides was 83.15 μg/L, which is below the maximum residue limit recommended by the European Union for sulfonamides in milk.

scholarly journals Development of a Performance Method for Determination of Cis/Trans Isomers of Oleic, Linoleic and Linolenic Acids from Potato Chips by GC-MS

2019 ◽  
Vol 76 (2) ◽  
pp. 114
Author(s):  
Mioara NEGOIȚĂ ◽  
Adriana Laura MIHAI ◽  
Alina Cristina ADASCĂLULUI ◽  
Enuța IORGA
Keyword(s):  
Trans Fatty Acids ◽  
Methyl Esters ◽  
Correlation Coefficients ◽  
Potato Chips ◽  
Trans Isomers ◽  
Simultaneous Quantification ◽  
Validation Parameters ◽  
Total Fat ◽  
Sensitive Method

The aim of this study was to develop and evaluate some validation parameters of a GC-MS sensitive method for the separation, identification, and simultaneous quantification of 18 cis/trans isomers of oleic (FAME C18:1), linoleic (FAME C18:2), and linolenic acid (FAME C18:3) methyl esters. Linearity, sensitivity, and recovery of the developed method were evaluated on calibration solutions. Correlation coefficients (R) were higher than 0.99 in the linear domain for each isomer, the sensitivity of the method was characterized by LOD = 0.03 - 0.05 g/100 g of fat, and LOQ = 0.09 - 0.17 g/100 g of fat, and the recovery ranged between 101.32 - 102.59%. Samples of potato chips were used to demonstrate the applicability of the method and the trans fatty acids (TFA) levels in analyzed sample were below 0.60 g/100 g fat, complying with international recommendations of less than 2 g/100 g of total fat. The proposed GC-MS method allows simultaneous determination of 18 cis/trans isomers (13 trans and 5 cis) of FAME C18 from potato chips.

Determination of N-acyl homoserine lactones in soil using accelerated solvent extraction combined with solid-phase extraction and gas chromatography-mass spectrometry

2017 ◽  
Vol 9 (4) ◽  
pp. 688-696 ◽  
Author(s):  
Hongjie Sheng ◽  
Yang Song ◽  
Yongrong Bian ◽  
Wei Wu ◽  
Leilei Xiang ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Solid Phase ◽  
Soil Samples ◽  
Gas Chromatography Mass Spectrometry ◽  
Phase Extraction ◽  
Homoserine Lactones ◽  
Simultaneous Quantification ◽  
Acyl Homoserine Lactones ◽  
Sensitive Method

A robust and sensitive method is established for the simultaneous quantification of seven AHLs in soil samples.

Development and validation of an LC-MS/MS method for simultaneous quantification of hesperidin and hesperetin in rat plasma for pharmacokinetic studies

2017 ◽  
Vol 9 (22) ◽  
pp. 3329-3337 ◽  
Author(s):  
Jr-Ting Lee ◽  
Li-Heng Pao ◽  
Chang-Da Hsieh ◽  
Pei-Wei Huang ◽  
Oliver Yoa-Pu Hu
Keyword(s):  
Wistar Rats ◽  
Rat Plasma ◽  
Pharmacokinetic Studies ◽  
Simultaneous Quantification ◽  
Development And Validation ◽  
Sensitive Method

A simple and sensitive method for the determination of hesperidin and hesperetin was necessary for a pharmacokinetic (PK) study in Wistar rats.

Relationship Between Total Prothrombin, Native Prothrombin and the International Normalized Ratio (INR)

1992 ◽  
Vol 68 (02) ◽  
pp. 160-164 ◽  
Author(s):  
P J Braun ◽  
K M Szewczyk
Keyword(s):  
Anticoagulant Therapy ◽  
Oral Anticoagulant ◽  
Inverse Relationship ◽  
Low Dose ◽  
Oral Anticoagulant Therapy ◽  
International Normalized Ratio ◽  
Antigen Assay ◽  
Dose Oral ◽  
Anticoagulated Patients ◽  
Sensitive Method

SummaryPlasma levels of total prothrombin and fully-carboxylated (native) prothrombin were compared with results of prothrombin time (PT) assays for patients undergoing oral anticoagulant therapy. Mean concentrations of total and native prothrombin in non-anticoagulated patients were 119 ± 13 µg/ml and 118 ± 22 µg/ml, respectively. In anticoagulated patients, INR values ranged as high as 9, and levels of total prothrombin and native prothrombin decreased with increasing INR to minimum values of 40 µg/ml and 5 µg/ml, respectively. Des-carboxy-prothrombin increased with INR, to a maximum of 60 µg/ml. The strongest correlation was observed between native prothrombin and the reciprocal of the INR (1/INR) (r = 0.89, slope = 122 µg/ml, n = 200). These results indicated that native prothrombin varied over a wider range and was more closely related to INR values than either total or des-carboxy-prothrombin. Levels of native prothrombin were decreased 2-fold from normal levels at INR = 2, indicating that the native prothrombin antigen assay may be a sensitive method for monitoring low-dose oral anticoagulant therapy. The inverse relationship between concentration of native prothrombin and INR may help in identification of appropriate therapeutic ranges for oral anticoagulant therapy.

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