Anti-hyperglycemic Activity and Inhibition of Advanced Glycation End Products by Lonicera japonica Thunb. in Streptozotocin-induced Diabetic Rats

2020 ◽  
Vol 26 (6) ◽  
pp. 825-835
Author(s):  
Yuko Shimamura ◽  
Masaharu Shibata ◽  
Midori Sato ◽  
Ryoji Nagai ◽  
Ping Yang ◽  
...  
Keyword(s):  
Advanced Glycation End Products ◽  
Diabetic Rats ◽  
Lonicera Japonica ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products

Accumulation of fructosyl-lysine and advanced glycation end products in the kidney, retina and peripheral nerve of streptozotocin-induced diabetic rats

2003 ◽  
Vol 31 (6) ◽  
pp. 1423-1425 ◽  
Author(s):  
N. Karachalias ◽  
R. Babaei-Jadidi ◽  
N. Ahmed ◽  
P.J. Thornalley
Keyword(s):  
Peripheral Neuropathy ◽  
Sciatic Nerve ◽  
Peripheral Nerve ◽  
Plasma Protein ◽  
Advanced Glycation End Products ◽  
Diabetic Rats ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products ◽  
Carboxymethyl Lysine

The accumulation of AGEs (advanced glycation end products) in diabetes mellitus has been implicated in the biochemical dysfunction associated with the chronic development of microvascular complications of diabetes – nephropathy, retinopathy and peripheral neuropathy. We investigated the concentrations of fructosyl-lysine and AGE residues in protein extracts of renal glomeruli, retina, peripheral nerve and plasma protein of streptozotocin-induced diabetic rats and normal healthy controls. Glycation adducts were determined by LC with tandem MS detection. In diabetic rats, the fructosyl-lysine concentration was increased markedly in glomeruli, retina, sciatic nerve and plasma protein. The concentrations of N∊-carboxymethyl-lysine and N∊-carboxyethyl-lysine were increased in glomeruli, sciatic nerve and plasma protein, and N∊-carboxymethyl-lysine also in the retina. Hydroimidazolone AGEs derived from glyoxal, methylglyoxal and 3-deoxylglucosone were major AGEs quantitatively. They were increased in the retina, nerve, glomeruli and plasma protein. AGE accumulation in renal glomeruli, retina, peripheral nerve and plasma proteins is consistent with a role for AGEs in the development of nephropathy, retinopathy and peripheral neuropathy in diabetes. High-dose therapy with thiamine and Benfotiamine suppressed the accumulation of AGEs, and is a novel approach to preventing the development of diabetic complications.

Ellagic acid inhibits non-enzymatic glycation and prevents proteinuria in diabetic rats

2016 ◽  
Vol 7 (3) ◽  
pp. 1574-1583 ◽  
Author(s):  
G. Raghu ◽  
Sneha Jakhotia ◽  
P. Yadagiri Reddy ◽  
P. Anil Kumar ◽  
G. Bhanuprakash Reddy
Keyword(s):  
Diabetic Nephropathy ◽  
Characteristic Feature ◽  
Advanced Glycation End Products ◽  
Ellagic Acid ◽  
Diabetic Rats ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products

The formation of advanced glycation end products (AGEs) is a characteristic feature of diabetic tissues and accumulation of AGEs been implicated in the pathogenesis of diabetic nephropathy (DN). Ellagic acid prevented the accumulation of AGEs and in turn ameliorated proteinurea in diabetic rats.

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