scholarly journals Pokazatelji dinamike funkcioniranja selektivne pažnje hrvatskih strojovođa i njihove dobne razlike

Sigurnost ◽  
2017 ◽  
Vol 59 (4) ◽  
pp. 331-354
Author(s):  
Mislav Stjepan Žebec ◽  
Ines Crnko ◽  
Vedrana Palavra ◽  
Davor Sumpor
Keyword(s):  
Traffic Safety ◽  
Aging Process ◽  
Stroop Test ◽  
Aging Effects ◽  
Test Form ◽  
Professional Drivers ◽  
Age Related ◽  
Stability And Resilience ◽  
Age Related Changes ◽  
Dynamic Indicators

SUMMARY: Research that focuses on aging process of selective attention (SA) functioning dynamics is very rare, especially regarding the professional drivers’ population. Given the fact that the consequences of SA functioning in railroad engineers are extremely high for traffic safety, we considered it important to investigate the aging effects on three indicators of SA system functioning dynamics (average efficiency, stability and resilience to the adverse factors effects) with regard to different measures of SA. The study was conducted using two time limited forms of Stroop tests: the first – verbal, uncoloured (lexical) and the second – verbal, coloured paper-pencil form. Both forms were comprised of two parts/components: with incongruent stimuli (measuring SA and processing speed, i.e. PS) and neutral stimuli (measuring only PS). The participants were male railroad engineers, ages 25 to 59, unevenly distributed into 4 age categories distinguished by specific functional characteristics of professional drivers. 50 subjects completed the first test form and 52 the second. The subjects’ task was to cross out as many of the target words in the distractors context in 60 seconds as possible (whereby the distraction was more intense for the incongruent stimuli). All three indicators of SA functioning dynamics are expressed as composites of objective measures of the Stroop test components. They show an unambiguous relation to the magnitude of the associated construct, while low inter-correlations indicate their diversity. With the exception of the relative position of the first test mistake - that could not be used as a measure of resilience due to the extremely small variability - in the selected sample of Croatian railroad engineers most of the other SA dynamic indicators show good statistical features and theoretical merits. Age related changes of the three SA dynamic indicators reflect a non-linear trend that is only partly in line with the expectations, while statistically significant only for SA resilience in the coloured version of the Stroop test. Although these age-related trends were mainly non-significant, average SA efficiency and stability in the coloured version of the test showed significantly different age-related changes in comparison to the lexical version of the test. Additionally, analyses have shown that the average SA efficiency is significantly higher in Stroop test that includes traffic relevant colours, while SA stability and resilience to the adverse factors effects show similar, although not significant, trend. The findings are – with a certain caution related to the lack of control group measurement and other methodological confinements specific for applied research - interpreted by specific railroad engineers experience and are discussed in relation to the theory of cognitive aging in the general population with the implications on the railroad engineers aging process and its consequences – especially regarding traffic safety.

scholarly journals Age-Related Changes in Methylome and Transcriptome of Hematopotietic Stem Cells Underlie Natural Genetic Variations

Blood ◽  
2016 ◽  
Vol 128 (22) ◽  
pp. 2660-2660
Author(s):  
Ying Liang
Keyword(s):  
Dna Methylation ◽  
Stem Cells ◽  
Stem Cell ◽  
Aging Process ◽  
Expression Patterns ◽  
Genetic Variations ◽  
Cell Aging ◽  
Hematopoietic Stem ◽  
Age Related ◽  
Age Related Changes

The aging of hematopoietic stem cells (HSCs) contributes to the aging of blood system and perhaps the whole organism. The aging process is coordinately determined by both genetic and epigenetic factors, and demonstrates inter-individual variations. We used high-throughput sequencing methods to study the age-dependent changes of genome-wide DNA methylation and gene expression patterns in HSCs of C57BL/6 (B6) and DBA/2 mouse strains, which have shown natural variations in HSC aging process. We observed global age-associated decrease of DNA methylation in both strains, but D2 HSCs have a stronger loss of epigenetic control than B6 stem cells during aging. Majority age-related changes of DNA methylation occur from young to mid-aged stages. We identified stable strain-specific differentially methylated regions (DMRs) that overlap with cis-eQTLs. Moreover, transcription factor binding site motifs are more likely to be disrupted in the DMRs, suggesting the potential impact of genetic variations on epigenetic regulation of HSC aging. We further demonstrated that strain-specific DMRs have more profound effects on the aging of B6 HSCs than D2 stem cells. Transposons are differentially regulated by the DMRs in the two strains, in which D2 HSCs are prone to transposon insertion. This study comprehensively investigated the effects of natural genetic and epigenetic variations on HSC aging. Loss of DNA methylation is an epigenetic signature of stem cell aging, and DNA methylation variations correlates with genetic variations, both contributing to inter-individual differences in stem cell and perhaps organismal aging. Disclosures No relevant conflicts of interest to declare.

scholarly journals Spatial and semantic interference on an auditory Stroop test: comparison of young and older adults

2021 ◽  
Author(s):  
Shubhaganga Dhrruvakumar ◽  
Asha Yathiraj
Keyword(s):  
Older Adults ◽  
Young Adults ◽  
Reaction Time ◽  
Spatial Localization ◽  
Stroop Test ◽  
Response Accuracy ◽  
Age Related ◽  
Semantic Localization ◽  
Left Front ◽  
Age Related Changes

Background and Aim: Age related changes in cognitive functioning have been shown to vary depending on the task used. Thus, the study aimed to compare the responses of young and older adults to an auditory Stroop test that asse­ssed spatial (responses to location of the stimuli) and semantic (responses to meaning of the sti­muli) localization. Methods: The “Auditory spatial and semantic localization Stroop test”, developed as a part of the study was administered on 30 young adults aged 18 to 30 years and 30 older adults aged 58 to 70 years having normal hearing. The res­ponse accuracy and reaction time of the parti­cipants were determined for the words “right”, “left”, “front”, and “back.” Results: The older adults had significantly poo­rer response accuracy and reaction time than the young adults for both spatial and semantic loca­lization tasks. Within each participant group, semantic localization had better response accu­racy than spatial localization, while such diffe­rences in reaction time were found only in the older adults. In both groups, a congruency effect was seen for spatial but not for semantic loca­lization when response accuracy was calculated, whereas it was observed only for semantic and not for spatial localization when reaction time was measured. Conclusion: The auditory Stroop test, which measures stimulus interference and cognitive skills, could be used as a simple tool to assess the same for stimuli presented through the audi­tory modality. This would be especially helpful in older adults who may demonstrate cognitive decline with ageing to auditory stimuli. Keywords: Spatial localization; semantic localization; auditory Stroop test; age related changes

scholarly journals Melatonin, aging, and COVID-19: Could melatonin be beneficial for COVID-19 treatment in the elderly?

2020 ◽  
Vol 50 (6) ◽  
pp. 1504-1512
Author(s):  
Güler ÖZTÜRK ◽  
Kazime Gonca AKBULUT ◽  
Şevin GÜNEY
Keyword(s):  
Aging Process ◽  
Biological Process ◽  
The Elderly ◽  
The Body ◽  
Biological Processes ◽  
Therapeutic Approaches ◽  
Free Radical Reactions ◽  
Age Related ◽  
The Relationship ◽  
Age Related Changes

The aim of this review is to summarize current studies on the relationship between melatonin and aging. Nowadays, age-related diseases come into prominence, and identifying age-related changes and developing proper therapeutic approaches are counted as some of the major issues regarding community health. Melatonin is the main hormone of the pineal gland. Melatonin is known to influence many biological processes in the body, including circadian rhythms, the immune system, and neuroendocrine and cardiovascular functions.Melatoninrhythms also reflect the biological process of aging. Aging is an extremely complex and multifactorial process. Melatonin levels decline considerably with aging and its decline is associated with several age-related diseases. Aging is closely associated with oxidative damage and mitochondrial dysfunction. Free radical reactions initiated by the mitochondria constitute the inherent aging process. Melatonin plays a pivotal role in preventing age-related oxidative stress. Coronavirus disease 2019 (COVID-19) fatality rates increase with chronic diseases and age, where melatonin levels decrease. For this reason, melatonin supplementation in elderly could be beneficial in COVID-19 treatment. Therefore, studies on the usage of melatonin in COVID-19 treatment are needed.

Age related changes in the activity-rest circadian rhythms and c-fos expression of ring doves with aging. Effects of tryptophan intake

2006 ◽  
Vol 41 (4) ◽  
pp. 430-438 ◽  
Author(s):  
Celia Garau ◽  
Sara Aparicio ◽  
Rubén V. Rial ◽  
María C. Nicolau ◽  
Susana Esteban
Keyword(s):  
Circadian Rhythms ◽  
Aging Effects ◽  
Age Related ◽  
Fos Expression ◽  
Ring Doves ◽  
Age Related Changes

scholarly journals AGE-RELATED CHANGES IN THE MUSCLE SECRETOME

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S101-S101
Author(s):  
Ning Zhang ◽  
Susan Weintraub ◽  
Nicolas Musi
Keyword(s):  
Mass Spectrometry ◽  
Aging Process ◽  
Young Group ◽  
The Body ◽  
Age Related ◽  
Secretion Profile ◽  
And Function ◽  
Old Mice ◽  
Body Support ◽  
Age Related Changes

Abstract Skeletal muscle is one of the most abundant tissues in the body. In addition to its key roles in body support, movement and metabolic homeostasis, muscle also functions as an endocrine/secretory organ producing and releasing proteins into the circulation that modulate distant tissues (i.e. myokines). Considering that muscle mass and function changes with advancing age, here we tested the hypothesis that aging alters the muscle secretome profile. After euthanasia, soleus muscles from sedentary young and old mice were dissected, and incubated in oxygenated KRB buffer for 2 h. The buffer was subjected to in-gel trypsin-digestion and peptides analyzed by mass spectrometry. The concentration of 36 proteins were significantly (P<0.05) elevated in the young vs. the old group. In contrast, only 7 proteins were significantly elevated in the old group. Some notable differences include those in HSPA1B and HSPA5 that were detected only in the young group. HSPA8 also was significantly elevated by 1.8-fold (P<0.05) in the young versus the old group. Another prominent difference between groups involved translationally controlled tumor protein (TCTP), a critical regulator of apoptosis/carcinogenesis, that was elevated by 7-fold in the young vs. the old group (P<0.05). These results indicate that aging alters the muscle secretion profile. Identified differences in the muscle secretome could reflect intrinsic changes in muscle cells with age. Because these myokines are released into the circulation, it is also possible that myokine secretion is a regulated cellular process by which muscle communicates and modulates the aging process in distant tissues.

scholarly journals LINKING VISUAL-SOMATOSENSORY INTEGRATION TO COGNITIVE AND MOTOR OUTCOMES IN AGING

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S469-S469
Author(s):  
Jeannette R Mahoney
Keyword(s):  
Aging Process ◽  
Multisensory Processing ◽  
Functional Decline ◽  
Daily Functioning ◽  
Younger Adults ◽  
Gait Performance ◽  
Future Studies ◽  
Age Related ◽  
Motor Outcomes ◽  
Age Related Changes

Abstract Ability to successfully integrate simultaneous information relayed across multiple sensory systems is an integral aspect of daily functioning. Unisensory impairments have been individually linked to slower gait, functional decline, and increased risks for falls in aging. Yet, research investigating age-related changes in multisensory integration (MSI) processes still remains relatively scarce. To date, there has been converging evidence for larger behavioral multisensory effects in older compared to younger adults; however, the question of whether larger effects are actually beneficial remains largely unanswered. Findings from our studies provide support for differential multisensory processing in aging, where decreased magnitude of visual-somatosensory integration was associated with worse balance, increased falls, and slower gait. Furthermore, we established a link between visual-somatosensory integration and cognition in aging. That is, magnitude of visual-somatosensory integration was largest in older adults with normal cognitive functioning, and presence of MCI/dementia significantly decreased magnitude of visual-somatosensory integration which in turn adversely impacted balance and gait performance. While the effect of MSI has been attributed to basic degenerative changes in neuronal architecture during the aging process, this speculative interpretation has yet to be formally tested. Future studies are clearly needed to establish the structural and functional correlates of MSI in aging, specifically visual-somatosensory integration, in order to further establish the link between differential multisensory effects with other important age-related clinical outcomes. Nevertheless, these studies stress the importance of successful MSI in aging, and highlight the need for multisensory based interventions that could potentially ameliorate disability.

scholarly journals Interregional causal influences of brain metabolic activity reveal the spread of aging effects during normal aging

2018 ◽  
Author(s):  
Xin Di ◽  
Marie Wölfer ◽  
Mario Amend ◽  
Hans Wehrl ◽  
Tudor M. Ionescu ◽  
...  
Keyword(s):  
Metabolic Activity ◽  
Fdg Pet ◽  
Aging Process ◽  
Brain Aging ◽  
Brain Regions ◽  
Causality Analysis ◽  
Aging Effects ◽  
Activity Data ◽  
Age Related ◽  
Brain Metabolic Activity

AbstractDuring healthy brain aging, different brain regions show anatomical or functional declines at different rates, and some regions may show compensatory increases in functional activity. However, few studies have explored interregional influences of brain activity during the aging process. We proposed a causality analysis framework combining high dimensionality independent component analysis (ICA), Granger causality, and LASSO (least absolute shrinkage and selection operator) regression on longitudinal brain metabolic activity data measured by Fludeoxyglucose positron emission tomography (FDG-PET). We analyzed FDG-PET images from healthy old subjects, who were scanned for at least five sessions with an averaged intersession interval of about one year. The longitudinal data were concatenated across subjects to form a time series, and the first order autoregressive model was used to measure interregional causality among the independent sources of metabolic activity identified using ICA. Several independent sources with reduced metabolic activity in aging, including the anterior temporal lobe and orbital frontal cortex, demonstrated causal influences over many widespread brain regions. On the other hand, the influenced regions were more distributed, and had smaller age related declines or even relatively increased metabolic activity. The current data demonstrated interregional spreads of aging on metabolic activity at the scale of a year, and have identified key brain regions in the aging process that have strong influences over other regions.

scholarly journals Aging Process in Chromatin of Animals

2012 ◽  
Vol 12 (3) ◽  
pp. 301-309
Author(s):  
Maciej Wnuk ◽  
Monika Bugno-Poniewierska ◽  
Anna Lewińska ◽  
Bernadetta Oklejewicz ◽  
Tomasz Ząbek ◽  
...  
Keyword(s):  
Dna Damage ◽  
Somatic Cell ◽  
Cellular Senescence ◽  
Aging Process ◽  
Genetic Factors ◽  
Special Consideration ◽  
Methylation Of Dna ◽  
Age Related ◽  
Biological Aspects ◽  
Age Related Changes

Aging Process in Chromatin of AnimalsThe aging process is a variable, stochastic and pleiotropic phenomenon which is regulated by different environmental and genetic factors. The age-associated changes, which occur at the molecular and cellular levels and disturb biological homeostasis, may directly or indirectly contribute to aging, causing apoptosis or cellular senescence and consequently leading to the death of the organism. In this context, it is particularly interesting to observe changes in somatic cell chromatin. In the present paper, we summarized the knowledge on the biological aspects of aging with special consideration of age-related changes in chromatin like DNA damage, shortening telomeres or age-related changes in methylation of DNA.

scholarly journals Proteomic and transcriptomic profiling reveal different aspects of aging in the kidney

2020 ◽  
Author(s):  
Yuka Takemon ◽  
Joel M. Chick ◽  
Isabela Gerdes Gyuricza ◽  
Daniel A. Skelly ◽  
Olivier Devuyst ◽  
...  
Keyword(s):  
Aging Process ◽  
Biological Processes ◽  
Age Changes ◽  
Molecular Changes ◽  
Protein Levels ◽  
Age Related ◽  
Organ Specific ◽  
Aging Kidney ◽  
Incomplete Picture ◽  
Age Related Changes

AbstractThe kidney is an excellent model for studying organ aging. Kidney function shows steady decline with age and is easy to assay using urine or blood samples. However, little is known about the molecular changes that take place in the kidney during the aging process. In order to better understand the molecular changes that occur with age, we measured mRNA and protein levels in 188 genetically diverse mice at ages 6, 12, and 18 months. We observed distinctive change in mRNA and protein levels as a function of age. Changes in both mRNA and protein are associated with increased immune infiltration and decreases in mitochondrial function. Proteins show a greater extent of change and reveal changes in a wide array of biological processes including unique, organ-specific features of aging in kidney. Most importantly, we observed functionally important age-related changes in protein that occur in the absence of corresponding changes in mRNA. Our findings suggest that mRNA profiling alone provides an incomplete picture of molecular aging in the kidney and that examination of changes in proteins is essential to understand aging processes that are not transcriptionally regulated.

Numerical Cognition during Cognitive Aging

2014 ◽  
Author(s):  
Kim Uittenhove ◽  
Patrick Lemaire
Keyword(s):  
Cognitive Aging ◽  
Numerical Cognition ◽  
Number System ◽  
Future Research ◽  
Aging Effects ◽  
Complex Arithmetic ◽  
Age Related ◽  
Number Comparison ◽  
Performance Variations ◽  
Age Related Changes

This chapter provides an overview of age-related changes and stabilities in numerical cognition. For each component (i.e. approximate and exact number system, quantification, and arithmetic) of numerical cognition, we review changes in participants’ performance during normal and pathological aging in a wide variety of tasks (e.g. number comparison, subitizing, counting, and simple or complex arithmetic problem-solving). We discuss both behavioral and neural mechanisms underlying these performance variations. Moreover, we highlight the importance of taking into account strategic variations. Indeed, investigating strategy repertoire (i.e. how young and older adults accomplish numerical cognitive tasks), selection (i.e. how participants choose strategies on each problem), execution (i.e. how strategies are implemented once selected), and distribution (i.e. how often participants use each available strategy) enables to determine sources of aging effects and individual differences in numerical cognition. Finally, we discuss potential future research to further our understanding of age-related changes in numerical cognition.

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