scholarly journals Dry Eye Disease among Pregnant Women at a Tertiary Care Hospital in Kathmandu

2020 ◽  
Vol 22 (3) ◽  
pp. 146-152
Author(s):  
Aparna Rizyal ◽  
B Shrestha ◽  
A Khadka
Keyword(s):  
Pregnant Women ◽  
Dry Eye ◽  
Tertiary Care ◽  
College Teaching ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Care Hospital ◽  
Dry Eyes ◽  
Schirmer’S Test ◽  
Woman's Body

Pregnancy is characterized by many significant changes in a woman’s body which helps develop the fetus optimally. During pregnancy, there is marked maternal endocrine upregulation, hormonal profile modifications and interactions leading to dry eyes. Pregnancy causes most parts of a woman’s body to change, and the eyes are no exception. Dry eye disease is a common pregnancy problem that usually begins towards the end of the first trimester. Since, there is a dearth of literature on dry eye disease during pregnancy in Nepal, a study was conducted to estimate the prevalence of dry eyes disease among pregnant women and to find its association with socio-demographic characteristics and their gestation period, at Nepal Medical College Teaching Hospital. A total of 84 pregnant women in different trimesters volunteered for this study. The upper and lower limits for estimated mean age were 26.67 years to 25.03 years at 95% confidence level. The prevalence of dry eyes was 89.3% by tear break up time test and 27.4% by Schirmer’s test respectively. The association between gestational age and dry eyes by Schirmer’s test was statistically significant.

Frequency and impact of individual symptoms on quality of life in dry eye disease in patients presenting to a tertiary care hospital

2021 ◽  
pp. 1-16
Author(s):  
Saba Ali Arif ◽  
Muhammad Ifraheem Khan ◽  
Muhammad Salman Abid ◽  
Ayla Babar ◽  
Mohammad Ali Arif ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Dry Eye ◽  
Tertiary Care ◽  
Tear Film ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Care Hospital ◽  
Cross Sectional ◽  
Department Of Ophthalmology

Abstract Objective: To assess the frequency of symptoms and impact on quality of life in individuals with dry eye disease. Methods: The cross-sectional, study was conducted from December 2018 to June 2019 at the outpatient clinic of the Department of Ophthalmology, Pakistan Institute of Medical Sciences, Islamabad, Pakistan, and comprised dry eye disease patients aged at least 13 years with ocular burning sensation, lacrimation, grittiness, photophobia, redness or itching. Tear Film Breakup time <10 sec and / or positive ocular surface staining >5 corneal spots, >9 conjunctival spots, lid margin staining ?2mm in length were used to diagnose the disease. Data was collected using the Dry Eye Quality of Life Score questionnaire. Data was analysed using SPSS 25. Results: of the 191 patients, 135(71%) were females and 56(29%) were males. The overall mean age was 39.8±16.6 years. Itching 155(81.2%), watering 151(79.1%) and burning 124(64.9%) were the most frequent symptoms, with watering (p<0.001) and photophobia (p=0.012) significantly impacting quality of life. Conclusions: The most common symptoms among patients of dry eye disease affecting their quality of life were itching, watering, burning, photophobia and low mood. Key Words: Quality of life in dry eye disease, Dry eye disease, Lacrimation, Photophobia, Continuous...

scholarly journals Comparative analysis of efficacy and adverse effects of tacrolimus vs cyclosporine in chronic dry eye disease: a tertiary care hospital based study

2018 ◽  
Vol 7 (11) ◽  
pp. 2216
Author(s):  
Zeenat Fatima ◽  
Rakesh Chandra Chaurasia ◽  
Satya Prakash Singh
Keyword(s):  
Dry Eye ◽  
Tertiary Care ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Eye Drops ◽  
Care Hospital ◽  
Ocular Surface Disease Index ◽  
Presenting Symptoms ◽  
Group 2 ◽  
Group 1

Background: Dry eye disease (DED) is the very common and underdiagnosed ocular condition affecting vision, quality of life, and the outcomes of cataract or refractive surgery. Dry eye disease (DED), either alone or in combination with other conditions, is a frequent cause of ocular irritation that leads the patients to seek ophthalmic care. Due to a wide variety of presenting symptoms, it is often unrecognized and this causes great frustration of the patient and treating physician. While these symptoms often improve with appropriate treatment, usually in majority of the cases the disease may not be curable. Aim of the study was to compare the efficacy of tacrolimus and cyclosporine in dry eye disease.Methods: This was a single centred, 3 months prospective study. Patients with unilateral or bilateral dry eye disease and an ocular surface disease index score >12, atleast one eye with schirmer score <5mm and TBUT <10 s were enrolled in the study. The enrolled patients were randomly divided into two groups, twenty-five patients in Group 1 and twenty three patients in Group 2 completed the follow up. Group 1(n =25) who received 0.03% tacrolimus eye ointment twice daily for consecutive 3 months and Group 2 (n= 23) received 0.05% cyclosporine eye drops twice daily for consecutive 3 months the primary efficacy outcome was Schirmer score after 3 months. The secondary outcomes were TBUT and adverse effects.Results: After 3 months, both the treatment groups showed significant improvement in mean Schirmer score (p<0.001) and mean TBUT (p <0.0001). However, on comparing both the groups, mean Schirmer score and mean TBUT, results were comparable. No patient discontinued treatment because of minor ocular adverse effects.Conclusions: Dry eye patients demonstrated improvement in Schirmer score and TBUT after 3 months of treatment with tacrolimus 0.03% ointment and cyclosporine 0.05% eye drops.

scholarly journals DRY-EYE DISEASE AMONG MEDICAL PROFESSIONALS IN A TERTIARY CARE HOSPITAL IN WESTERN UP DURING THE LOCKDOWN PERIOD 2020 – A CROSSSECTIONAL STUDY.

2020 ◽  
pp. 1-4
Author(s):  
Neelima Mehrotra ◽  
Amrita Bajpai Mishra ◽  
Alia Yamin ◽  
Ruchi Saxena ◽  
Ashwani Srivastava
Keyword(s):  
Dry Eye ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Medical Professionals ◽  
Care Hospital ◽  
Human Beings ◽  
Ocular Surface Disease Index ◽  
Cross Sectional

Objective : To estimate the prevalence of dry-eye disease (DED) among medical professionals in a tertiary care hospital in Western UP during the lockdown period 2020. Materials & Methods : This was a cross-sectional hospital-based, observational study from 7th May 2020 till 14th May 2020, that included 50 medical professionals as subjects. The study compares the increase in the number of hours spent on Visual Display Terminals (VDTs) before and during the lockdown period 2020. This in-turn led to numerous ill-effects on human beings, out of which ocular manifestations like dry-eye disease has been on the rise. The study has been carried out in the form of questionnaire survey data – Ocular Surface Disease Index (OSDI) asking about the symptoms and various other parameters, related to dry eye. Results : The mean number of hours spent on VDTs before lockdown was 2.82±1.32 hours and during lockdown was 6.26±4.76 hours. In accordance with the OSDI scoring, 23/50 subjects developed DED. Out of these, 28% (14/50) had mild DED, 16% (8/50) had moderate DED, and only 2% (1/50) had severe DED. Prevalence of dry eye was directly proportionate to exposure time to VDT during the lockdown. Conclusion : The prevalence of dry-eye disease (DED) among medical professionals during the lockdown period 2020 was 46%. This was attributed to the increased dependence on VDTs for various purposes.

scholarly journals A comparative assessment of dry eye disease among outdoor street sweepers and indoor office cleaners

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Chigozie I. Echieh ◽  
Bassey A. Etim ◽  
Chidiebere Peter Echieh ◽  
Taiwo Oyeniyi ◽  
Jeff Ajewole
Keyword(s):  
Dry Eye ◽  
Cross Sectional Study ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Ocular Surface Disease Index ◽  
Simultaneous Exposure ◽  
Cross Sectional ◽  
Systematic Random Sampling ◽  
Schirmer’S Test ◽  
Multi Stage

Abstract Background Occupational predisposition to dry eye disease is known. Simultaneous exposure to multiple factors may pose more risk. Street sweepers are exposed to sunlight in addition to dust which all sweepers are exposed to. Tropical climate predisposes to significant exposure to sunlight. Combined exposure to dust and sunlight may lead to a synergy of factors. This study aims to assess the prevalence of dry eye disease (DED) amongst Street sweepers and Office cleaners in Calabar metropolis. Methods A cross-sectional study was conducted among street sweepers and office cleaners. A systematic random sampling and multi-stage sampling method were used to select street sweepers (n = 115) and office cleaners (n = 115) respectively for the study. A pretested semi-structured interviewer-administered questionnaire was used to obtain information after which the respondents had an ophthalmic examination. An assessment of DED was done with Ocular Surface Disease Index (OSDI) questionnaire, Schirmer’s test, and tear break up time (TBUT). OSDI scores of 33 and above; Schirmer’s test readings of < 10 mm wetting in 5 min and a TBUT of less than 10s in either eye were considered as positive dry eye disease. Results The majority of respondents were females 215(93.5%) compared to males 15 (6.5%). The overall mean age of respondents was 40.96 ± 9.8 years. The average OSDI score, Schirmer’s test as well as TBUT among participants was 26.4 ± 16.0, 16.44 ± 9.52 mm, and 12.38 ± 4.53 s respectively. The prevalence of DED among Street sweepers was 35.7% compared to 20% among office cleaners using the OSDI questionnaire (p = 0.352). The prevalence of DED among street sweepers was 32.2% compared to 30.4% among Office cleaners using the Schirmer’s test. (p = 0.73) The TBUT reported a prevalence of 38.3% of DED among Street sweepers compared to 32.2% in office cleaners. (p = 0.48) Overall; the prevalence of dry eye disease among Street sweepers and office cleaners using OSDI score, Schirmers test, as well as TBUT were not statistically significant (> 0.05) Street Sweepers had higher odds of developing dry eye disease compared to office cleaners (OR = 2.085; C.I. =1.106–3.929; p = 0.02). Negative correlation coefficient was observed between TBUT and OSDI (rs = − 0.102; p = 0.125). This was not statistically significant. Conclusion Street sweepers had a higher prevalence of dry eye disease compared to office cleaners due to a higher risk of increased exposure to environmental factors such as dust, smoke, and sunlight. This effect is possibly due to a synergy of factors. Studies on dose-response are warranted.

scholarly journals Frequency of efficacy of topical cyclosporine 0.05% eye drops in the management of dry eyes

2021 ◽  
Vol 15 (6) ◽  
pp. 1384-1386
Author(s):  
M. Khalid ◽  
M. Rizwan ◽  
S. Khurshid
Keyword(s):  
Dry Eye ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Eye Drops ◽  
Care Hospital ◽  
Improvement Rate ◽  
Female Patients ◽  
Department Of Ophthalmology ◽  
Male Patients ◽  
Efficacy Of Treatment

Aim: To determine the efficacy of cyclosporine 0.05% for the management of patients of dry-eye disease presenting at tertiary care hospital. Methods: This cross sectional study was conducted at Department of Ophthalmology, Sahiwal Medical College, Sahiwal from March 2020 to September 2020 over the period of 6 months.Total 310 patients of dry eye were included in this study after scrutinized by inclusion criteria. All the selected patients were managed with cyclosporine 0.05% and efficacy of the drug was assessed. Results: Total 310 patients of dry eye disease were recruited. Mean age was 47.15 ± 3.61 years and mean duration of dry eye disease was 11.10 ± 1.75 months. Out of 310 patients, treatment was found effective in 225 (73%) patients. Efficacy of treatment was noted in 172(96.63%) male patients and in 53(40.15%) female patients. Significantly higher rate of efficacy was noted in male patients as compared to female patients with p value 0.000. Conclusion: Results of present study showed higher improvement rate of dry eye symptoms in cases of dry eye managed with cyclosporine 0.05%. Male patients were more victim of dry eye as compared to female patients and statistically significant association of efficacy with gender was observed. No association of efficacy of treatment with age group and duration of disease was observed. Keywords: Dry eye, cyclosporine, inflammation, immunomodulator agents.

scholarly journals Defining the needs and preferences of patients with dry eye disease

2019 ◽  
Vol 4 (1) ◽  
pp. e000315
Author(s):  
Penny Asbell ◽  
Elisabeth Messmer ◽  
Colin Chan ◽  
Gary Johnson ◽  
Brigitte Sloesen ◽  
...  
Keyword(s):  
Dry Eye ◽  
Treatment Effectiveness ◽  
Visual Disturbance ◽  
Dry Eye Disease ◽  
Phone Call ◽  
Eye Disease ◽  
Online Questionnaire ◽  
Dry Eyes ◽  
Substantial Impact ◽  
Emerging Trends

ObjectiveDry eye disease is a multifactorial chronic disease, leading to ocular discomfort and visual disturbance with a substantial impact on quality of life. Therefore, the patient’s perspective should be taken into account early in the drug development process. We have developed a step-by-step methodology based on the self-explicated conjoint approach to assess the needs and preferences of patients with moderate-to-severe dry eye disease.Methods and AnalysisFollowing a literature review and social media listening (step 0), qualitative phone call interviews were conducted with 12 patients (step 1). Patients’ responses underwent content analysis and were coded, quantified and displayed as charts. Based on the emerging trends and attributes identified as relevant in steps 0 and 1, a quantitative online questionnaire was designed and conducted with 160 patients across four countries (step 2).ResultsThe online questionnaire was rated as easy/very easy to understand by 60% of respondents, 62% rated the survey as easy/very easy to complete and 71% rated it as interesting/very interesting. Treatment satisfaction was the most important aspect for patients, and the three most relevant attributes were as follows (with the most important indexed to 100%): ‘treatment effectiveness on symptoms of dry eyes’ (100%), ‘frequency of treatment use’ (96%) and ‘how the treatment works’ (95%).ConclusionOur methodology was well received by patients, and the results will help inform future clinical trial development and discussions with health technology assessment bodies and regulators on unmet needs and product attributes that are of most value to patients with dry eye disease.

scholarly journals Characteristics and Utility of Fluorescein Breakup Patterns among Dry Eyes in Clinic-Based Settings

Diagnostics ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 711
Author(s):  
Chika Shigeyasu ◽  
Masakazu Yamada ◽  
Norihiko Yokoi ◽  
Motoko Kawashima ◽  
Kazuhisa Suwaki ◽  
...  
Keyword(s):  
Diagnostic Test ◽  
Dry Eye ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Subjective Symptoms ◽  
Clinical Tool ◽  
Likelihood Ratios ◽  
Dry Eyes ◽  
Post Test ◽  
Breakup Time

(1) Background: To evaluate the characteristics of fluorescein breakup patterns (FBUPs) among patients with dry eye disease (DED) and efficacy of FBUPs as a diagnostic test for DED subgroups. (2) Methods: The study enrolled 449 patients with DED. FBUPs were categorized as follows: area break (AB), line break (LB), spot break (SB), dimple break (DB), and random break (RB). Schirmer value, fluorescein breakup time (FBUT), keratoconjunctival score, DED subgroups and subjective symptoms were examined. (3) Results: LB patients presented with short FBUT and high keratoconjunctival score. AB patients presented with short FBUT, high cornea and keratoconjunctival scores. SB patients were young with short FBUT. DB patients exhibited low keratoconjunctival score. RB patients were young, with long FBUT and low keratoconjunctival scores. Among DED subgroups, LB and AB constituted 74.7% of aqueous-deficiency dry eye (ADDE). SB and DB constituted 42.4% of short FBUT dry eye (short FBUT-DE). Post-test probabilities and positive likelihood ratios for ADDE were 58.7% and 1.63, respectively; those for short FBUT-DE were 46.3% and 2.02, respectively. Patients with SB and AB exhibited significantly severe subjective symptoms than other FBUPs. (4) Conclusions: FBUPs are associated with both objective findings and symptoms of DED and may be a clinical tool for identification of DED subgroups.

scholarly journals Determination of Risk Factors and Treatment of Dry Eye Disease in Type 1 Diabetes Before Corneal Complications at Sindh Institute of Ophthalmology And Visual Sciences

2017 ◽  
Vol 11 (1) ◽  
pp. 355-361 ◽  
Author(s):  
Shehnilla Shujaat ◽  
Muhammad Jawed ◽  
Shahzad Memon ◽  
Khalid Iqbal Talpur
Keyword(s):  
Risk Factors ◽  
Type 1 Diabetes ◽  
Dry Eye ◽  
Tear Film ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Diabetic Patients ◽  
Dry Eyes ◽  
Department Of Ophthalmology

Objective: The objective of this study was to assess and determine the risk factors and treatment of dry eye disease in type 1 diabetes before any ocular surface or corneal complication occurs. This study was conducted at Sindh Institute of Ophthalmology And Visual Sciences, Hyderabad, Pakistan. Methodology: Subjects and methods for observational study were undertaken at the Department of Ophthalmology Sindh Institute Of Ophthalmology And Visual Sciences, Hyderabad, Pakistan. Hundred confirmed cases of type 1 diabetes were included in the study by non probability convenience sampling. Tear film breakup time and schrimer test were carried out to determine dry eye disease. Data was collected by self-prepared questionnaire and entered and analyzed by using Statistical Program for Social Sciences (SPSS, version 20.0). The frequencies and percentage were recorded and any associations with predisposing factors were statistically analyzed by t test. Results: Out of hundred patients, 71 (71%) were found to have dry eyes (P<0.001). The mean age of the subject in this study was 50.97 years (range 30-70 years). Old age was related to high risk of dry eye disease (P<0.001). There was no big difference in the incidence of dry eyes in males and females. Long duration was found to be related with increased occurrence of dry eyes (P<0.001). We found higher values for abnormal tear film break up time than schirmer test values leading to increased occurrence of evaporative dry eyes. Conclusion: There is marked increase in frequency/ risk of developing dry eye disease in type 1 diabetes patients. Therefore, it is recommended to have periodic ophthalmic examination for type 1 diabetic patients.

Sign in / Sign up

Export Citation Format

Share Document