scholarly journals Caesalpinia volkensii: Unexploited Natural Source of Medicine

2018 ◽  
Vol 7 (3) ◽  
pp. 288-291
Author(s):  
Michael Musila Ndile ◽  
◽  
Wilton Mwema Mbinda ◽  
Mathew Piero Ngugi ◽  
◽  
...  
Keyword(s):  
Antimicrobial Property ◽  
Natural Source ◽  
Phytochemical Analysis ◽  
Traditional Use ◽  
Hypoglycaemic Activity ◽  
Scientific Potential ◽  
Lifestyle Diseases

The plant of the species Caesalpinia volkensii has diverse traditional use. This review aims at providing an overview of the plants traditional utility and scientific potential in managing both infectious and lifestyle diseases. It focuses on the plants hypoglycaemic activity, anti-malarial, anti-nociceptive and anti-inflamatory activity. The review also looks at the antimicrobial property of the plant, phytochemical analysis and safety

scholarly journals In VitroAntimicrobial Activity of Extracts from Plants Used Traditionally in South Africa to Treat Tuberculosis and Related Symptoms

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Balungile Madikizela ◽  
Ashwell Rungano Ndhlala ◽  
Jeffrey Franklin Finnie ◽  
Johannes Van Staden
Keyword(s):  
South Africa ◽  
South African ◽  
Respiratory Infections ◽  
Antimicrobial Properties ◽  
Antimicrobial Activities ◽  
Phytochemical Analysis ◽  
Traditional Use ◽  
Microbial Strains ◽  
African Plants ◽  
Mycobacterium Aurum

Respiratory ailments are major human killers, especially in developing countries. Tuberculosis (TB) is an infectious disease causing a threat to human healthcare. Many South African plants are used in the traditional treatment of TB and related symptoms, but there has not been a sufficient focus on evaluating their antimicrobial properties. The aim of this study was to evaluate the antimicrobial properties of plants used traditionally to treat TB and related symptoms against microorganisms (Klebsiella pneumoniae, Staphylococcus aureus,andMycobacterium aurumA+) associated with respiratory infections using the microdilution assay. Ten plants were selected based on a survey of available literature of medicinal plants used in South Africa for the treatment of TB and related symptoms. The petroleum ether, dichloromethane, 80% ethanol, and water extracts of the selected plants were evaluated for antibacterial activity. Out of 68 extracts tested from different parts of the 10 plant species, 17 showed good antimicrobial activities against at least one or more of the microbial strains tested, with minimum inhibitory concentration ranging from 0.195 to 12.5 mg/mL. The good antimicrobial properties ofAbrus precatorius, Terminalia phanerophlebia, Indigofera arrecta,andPentanisia prunelloidesauthenticate their traditional use in the treatment of respiratory diseases. Thus, further pharmacological and phytochemical analysis is required.

Identification of TRPV1 Ion Channels Agonists of Tropaeolum tuberosum in Human Skin Keratinocytes

Planta Medica ◽  
2020 ◽  
Author(s):  
Luis Apaza Ticona ◽  
Ángel Rumbero Sánchez ◽  
Cristina Thiebaut Estrada ◽  
Olga M. Palomino
Keyword(s):  
Transient Receptor Potential ◽  
Herbal Remedy ◽  
Scientific Evidence ◽  
Receptor Potential ◽  
Transient Receptor Potential Vanilloid ◽  
Phytochemical Analysis ◽  
Traditional Use ◽  
Bladder Pain ◽  
Transient Receptor ◽  
Tropaeolum Tuberosum

Abstract Tropaeolum tuberosum, commonly known as Mashua, is an herbal remedy used in traditional Andean medicine for the relief of kidney and bladder pain, as well as contusions. This study aimed to evaluate the fractions and isolated compounds from T. tuberosum with analgesic activity mediated by the transient receptor potential vanilloid-1 receptor. A bioguided phytochemical analysis based on NMR/MS was performed to identify the compounds of the n-heptane fractions from samples of purple tubers of T. tuberosum. The transient receptor potential vanilloid-1 agonist and antagonist activity were assessed through the measurement of intracellular Ca2+ in HEK001 cells. The chemical structure determination led to the identification of two alkamides: N-(2-hydroxyethyl)-7Z,10Z,13Z,16Z-docosatetraenamide (1) and N-oleoyldopamine (2). Both compounds induced increased intracellular calcium flow with IC50 values of 3.2 nM and 7.9 nM, respectively, thus activating the transient receptor potential vanilloid-1 receptor. Our research is the first report to show that these two compounds isolated from T. tuberosum can act as agonists of the transient receptor potential vanilloid-1 receptor, providing scientific evidence for the traditional use of this species in pain relief.

scholarly journals VALIDATION OF TRIBAL CLAIMS ON MORINGA OLEIFERA LAM. USING PHYTOCHEMICAL ANALYSIS

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Getsial Sabatini Wallace J ◽  
S. Naveen Kumar ◽  
V. Negasta Smila ◽  
T. Nivitha ◽  
Stalin Nithaniyal ◽  
...  
Keyword(s):  
Moringa Oleifera ◽  
Therapeutic Potential ◽  
Biological Activities ◽  
Future Research ◽  
Phytochemical Analysis ◽  
Traditional Use ◽  
Phytochemical Study ◽  
Medicinal Uses ◽  
Pharmacological Significance ◽  
History Of

Moringa is a medicinally important genus that has long history of traditional use as a remedy to cure wounds and various ailments such as colds, diabetes, digestive problems etc. In addition, the species is consumed as a source of nutritive food and used as vegetables worldwide. The genus consists of 13 species that have been cultivated throughout Asia and Africa for their multiple purpose use value. The current study is aimed to validate the traditional medicinal uses of Moringa oleifera, provide scientific insights on the phytochemistry, biological activities and thereby correlating its therapeutic potential for future prospects. Analysis of phytochemical profile showed the presence of the major important bioactive compounds (saponin, tannin, flavonoids, phenolics, and reducing sugar) that were assessed in aqueous, methanolic aqueous and acetone-aqueous extracts following standard procedures. This study provides the foundation to explore the tribal medicinal use complemented with the scientific evaluation. Our study reinforce further phytochemical study with advanced technologies for future research opportunities of this species as it is an interesting plant containing commercially important active compounds that enable to determine pharmacological significance, and socio-economic potential.

scholarly journals Sedative and anxiolytic effect of the methanolic extract of Erythrina edulis Triana ex Micheli in mice

Bionatura ◽  
2018 ◽  
Vol 01 (Bionatura Conference Serie) ◽  
Author(s):  
Josué Sarmiento ◽  
Mariana Saa ◽  
Eugenia Peñaherrera
Keyword(s):  
Anxiolytic Effect ◽  
Artemia Salina ◽  
Anxiolytic Activity ◽  
Phytochemical Analysis ◽  
Traditional Use ◽  
Elevated Plus Maze Test ◽  
Sedative Activity ◽  
The Central Nervous System ◽  
Cd1 Mice ◽  
Traction Test

The traditional use of medicinal plants and its link with pharmacological studies is essential in order to corroborate the effect scientifically. The present work was an experimental study designed to investigate the sedative and anxiolytic effect of the methanol extract of the leaves of Erythrina edulis. The extract was prepared by percolation. Different concentrations: 500, 250 and 125 mg/kg of the extract and diazepam as a controlled drug were administered intraperitoneally to Swiss CD1 mice for both, sedation and anxiety tests. The sleep enhancement test with pentobarbital and the traction test were used for the sedative activity. Results showed that the extract did not possess sedative activity in any of the administered doses. However, the possibility of an opposite effect was observed as an activation of the central nervous system probably. The anxiolytic activity was evaluated by the open field test and the elevated plus maze test, where a behavior with a low level of anxiety was observed. Altogether, the results suggest that the extract has an anxiolytic activity without sedation, which supports traditional use. But, its responses are not dose-dependent, and its mechanism of action is unknown. Besides, toxicity assay was performed in Artemia salina nauplii, resulting in a lethal concentration 50 of 16.570 ug/mL corresponding to zero toxicity. Finally, the phytochemical analysis of the extract revealed the presence of flavonoids (flavonols, flavones and phenolic carboxylic acids), anthrones, anthranols, terpenes (mono and sesquiterpenes), saponins and hydrolysable tannins.

scholarly journals In Vitro Gingival Wound Healing Activity of Extracts from Reynoutria japonica Houtt Rhizomes

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1764
Author(s):  
Izabela Nawrot-Hadzik ◽  
Adam Matkowski ◽  
Artur Pitułaj ◽  
Barbara Sterczała ◽  
Cyprian Olchowy ◽  
...  
Keyword(s):  
Wound Healing ◽  
Laser Scanning ◽  
Immunocytochemical Staining ◽  
Confocal Laser ◽  
Phytochemical Analysis ◽  
Chinese Medicinal Herb ◽  
Traditional Use ◽  
Reynoutria Japonica ◽  
Collagen Iii

Rhizomes of Reynoutria japonica Houtt. are a traditional Chinese medicinal herb (Polygoni cuspidati rhizoma, hu zhang) used for treatment of numerous diseases including wound healing support. The aim of this study was to provide evidence for the value of this herbal drug’s traditional use as a gingival healing treatment as well as to obtain the most active extract. In vitro studies were performed using primary human gingival fibroblasts (HGFs) with determination of viability (MTT assay), cell proliferation (the confocal laser scanning microscope (CLSM) was used to visualize histone 3 expression), cell migration (wound healing assay), and evaluation of the expression of collagen type III (immunocytochemical staining) after incubation with extracts from R. japonica rhizomes (25% or 40% ethanol or 60% acetone). In addition to these extracts, commercial dental rinse (containing chlorhexidine digluconate 0.2%) was tested as the gold standard of choice for gum healing in dental practice. The studied extracts were qualitatively and quantitatively characterized using the validated HPLC/DAD/ESI-HR-QTOF-MS method. Total phenols and tannins content were determined using the Folin–Ciocalteu assay. Low concentration of all extracts after 24 h incubation caused significant increase in HGF viability. This effect was most pronounced at a concentration of 50 µg/mL, which was selected for further experiments. All extracts (at 50 µg/mL) stimulated HGF to proliferate, migrate, and increase collagen III synthesis, but with different strength. The highest stimulated proliferation and migration activity was observed after incubation with 25% EtOH, which according to phytochemical analysis may be related to the highest content of resveratrol and an appropriate composition of procyanidins. The 25% EtOH extract from R. japonica rhizomes appears to be a promising gingival wound healing agent worthy of animal and clinical trials.

scholarly journals Phytochemical analysis and antifungal property of Mallotus oppositifolius (Geiseler) Müll.Arg. (Euphorbiaceae)

2021 ◽  
Vol 15 (2) ◽  
pp. 414-426
Author(s):  
Vincent Ngouana ◽  
Patrick Valere Tsouh Fokou ◽  
Elisabeth Zeuko’o Menkem ◽  
Valerie Flore Donfack Donkeng ◽  
Ghislain Wabo Fotso ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Crude Extract ◽  
Methylene Chloride ◽  
Antifungal Drugs ◽  
Phytochemical Analysis ◽  
Antifungal Property ◽  
Traditional Use ◽  
Trichophyton Soudanense ◽  
Microsporum Audouinii ◽  
Pure Compounds

The emergence of resistant fungi to available drugs highlights the need for new antifungal drugs. The present study aimed to evaluate the antifungal activity of the isolated compounds, fractions and crude extract from the leaf of Mallotus oppositifolius (Geiseler) Müll. Arg. Three pure compounds labelled 1-3 were isolated from the methylene chloride / methanol (1/1) extract of the leaf of this plant using chromatography techniques. These compounds were identified using analytical spectroscopic methods as betulinic acid (1), quercetine (2) and quercitin (3). The crude extract, fractions and compounds were tested against pathogenic yeasts (Candida albicans, Candida glabrata, Candida krusei) and dermatophytes (Trichophyton rubrum, Trichophyton soudanense, Microsporum audouinii, Microsporum langeronii) using agar well diffusion and dilution methods. The safety of the crude extract was studied on Wistar rats according to the WHO guidelines. The minimal inhibitory concentration (MIC) values ranged from 48 to 781 μg/ml against yeasts for crude extract and fractions, and 1.86 to 25000 μg/ml against dermatophytes for pure compounds, fractions and crude extract. The antifungal activity of pure compounds was not determined against yeasts. The crude extract of leaf was found to be safe in rat at up to 12 g/kg. The results achieved supported the traditional use of Mallotus oppositifolius leaf for the treatment of fungal infections.Keywords: Mallotus oppositifolius, antifungal activity, safety, phytochemical screening.

scholarly journals The Phytochemical and Biological Investigation of Jatropha pelargoniifolia Root Native to the Kingdom of Saudi Arabia

Molecules ◽  
2018 ◽  
Vol 23 (8) ◽  
pp. 1892 ◽  
Author(s):  
Hanan Aati ◽  
Ali El-Gamal ◽  
Oliver Kayser ◽  
Atallah Ahmed
Keyword(s):  
Inflammatory Activity ◽  
In Vivo Model ◽  
Phytochemical Analysis ◽  
Dependent Manner ◽  
Isolation And Identification ◽  
Traditional Use ◽  
In Vivo Models ◽  
Induced Hyperthermia ◽  
Anti Inflammatory

Extensive phytochemical analysis of different root fractions of Jatropha pelargoniifolia Courb. (Euphorbiaceae) has resulted in the isolation and identification of 22 secondary metabolites. 6-hydroxy-8-methoxycoumarin-7-O-β-d-glycopyranoside (15) and 2-hydroxymethyl N-methyltryptamine (18) were isolated and identified as new compounds along with the known diterpenoid (1, 3, 4, and 7), triterpenoid (2 and 6), flavonoid (5, 11, 13, 14, and 16), coumarinolignan (8–10), coumarin (15), pyrimidine (12), indole (17, 18), and tyramine-derived molecules (19–22). The anti-inflammatory, analgesic, and antipyretic activities were evaluated for fifteen of the adequately available isolated compounds (1–6, 8–11, 13, 14, 16, 21, and 22). Seven (4, 6, 10, 5, 13, 16, and 22) of the tested compounds showed a significant analgesic effect ranging from 40% to 80% at 10 mg/kg in two in vivo models. Compound 1 could also prove its analgesic property (67.21%) when it was evaluated on a third in vivo model at the same dose. The in vitro anti-inflammatory activity was also recorded where all compounds showed the ability to scavenge nitric oxide (NO) radical in a dose-dependent manner. However, eight compounds (1, 4, 5, 6, 10, 13, 16, and 22) out of the fifteen tested compounds exhibited considerable in vivo anti-inflammatory activity which reached 64.91% for compound 10 at a dose of 10 mg/kg. Moreover, the tested compounds exhibited an antipyretic effect in a yeast-induced hyperthermia in mice. The activity was found to be highly pronounced with compounds 1, 5, 6, 10, 13, and 16 which decreased the rectal temperature to about 37 °C after 2 h of the induced hyperthermia (~39 °C) at a dose of 10 mg/kg. This study could provide scientific evidence for the traditional use of J. pelargoniifolia as an anti-inflammatory, analgesic, and antipyretic.

scholarly journals Fractions of Selaginella convoluta (Arn.) Spring (Selaginellaceae) attenuate the nociceptive behavior events in mice

2020 ◽  
Vol 80 (1) ◽  
pp. 57-65 ◽  
Author(s):  
L. A. R. Oliveira-Macêdo ◽  
A. G. M. Pacheco ◽  
S. R. G. Lima-Saraiva ◽  
J. C. Silva ◽  
R. G. Oliveira-Júnior ◽  
...  
Keyword(s):  
Motor Coordination ◽  
Antinociceptive Effect ◽  
Phytochemical Analysis ◽  
Second Phase ◽  
Significant Activity ◽  
Nociceptive Behavior ◽  
Hot Plate ◽  
Traditional Use ◽  
Rota Rod Test ◽  
Anti Inflammatory

Abstract Selaginella convoluta (Arn.) Spring is a species popularly known as “jericó”, and used in folk medicine as analgesic and anti-inflammatory. This study aimed to investigate in mice the antinociceptive and anti-inflammatory activities of the hexane (Sc-Hex) and chloroform (Sc-CHCl3) fractions (100, 200 and 400 mg/kg) obtained by partition of crude ethanol extract from S. convoluta. The preliminary phytochemical analysis of the fractions was performed. Antinociceptive activity was evaluated by writhing, formalin and hot-plate tests. Anti-inflammatory activity was evaluated using carrageenan-induced pleurisy. The rota-rod test was used to evaluate motor coordination. Preliminary phytochemical screening showed that the Sc-Hex and the Sc-CHCl3 were positive for the presence of flavonoids, anthracene derivatives, quinones, triterpenes and steroids. Inhibition of writhing was observed for fractions tested. The Sc-Hex at all doses tested was effective in reducing the nociceptive behavior produced by formalin only in the second phase. However, the Sc-CHCl3 decreased the paw licking time in the first and second phases. In the hot plate no significant effect was observed for any fraction. In the rota-rod test, treated mice did not demonstrate any significant motor performance changes. In the carrageenan-induced pleurisy, Sc-CHCl3 (200 mg/kg) reduced cell migration to the pleural cavity. These results reveal the antinociceptive properties of S. convoluta , which support, in part, its traditional use, since the fractions did not presented significant activity in the inflammatory response profile. We further verify that this antinociceptive effect could be by activation of nociceptive peripheral pathway.

Sign in / Sign up

Export Citation Format

Share Document