Cadherin 5 is differentially expressed in non-small cell lung cancer and associates with patient survival.
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Non-small cell lung cancer (NSCLC) is the leading cause of cancer death in the United States (1). We mined published microarray data (2, 3, 4) to identify differentially expressed genes in NSCLC. We found that the gene encoding cadherin 5 (Cdh5) was among those whose expression was most quantitatively different in human NSCLC tumors as compared to the lung. Cdh5 expression levels were significantly decreased in NSCLC tumors as compared to the lung, and lower expression of Cdh5 in patient tumors was significantly associated with worse overall survival. Cdh5 may be important for initiation or progression of non-small cell lung cancer in humans.
2020 ◽
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2020 ◽
Keyword(s):
2020 ◽
Keyword(s):
2020 ◽
Keyword(s):
2020 ◽
2020 ◽
2020 ◽
2020 ◽
2020 ◽