Anthropometric measurements in infants conceived by assisted reproductive techniques versus spontaneous conception

2013 ◽  
Vol 27 (13) ◽  
pp. 1309-1311
Author(s):  
Rinat Gabbay-Benziv ◽  
Arnon Wiznitzer ◽  
Benjamin Fisch ◽  
Avi Ben-Haroush
2020 ◽  
Author(s):  
Virág Márton

A retrospective cohort study was carried out to reveal the characteristics and the perinatal outcome of vanishing twin pregnancies after spontaneous conception and after assisted reproductive techniques (ART). Vanishing twin (VT) syndrome, defined as the disappearance of one of two embryos with the survival of the co-twin during the first trimester, has been known for more than four decades. Due to the high and ever growing number of assisted reproductive treatments, the incidence of twin pregnancies and thus of vanishing twin syndrome is high. Recent studies have only examined vanishing twins after ART, but we hypothesized that there is a difference in perinatal outcomes between VT pregnancies, depending on the mode of conception, possibly reflecting the potential differences between underlying pathomechanisms. Our study consisted of two parts. We initiated the first study to compare obstetric and neonatal outcomes between the survivors of VT pregnancies and matched originally singleton control pregnancies, and a second study to evaluate whether VT pregnancies after spontaneous conception have a more adverse perinatal outcome than those conceived after assisted reproductive techniques. The study involved 316 VT pregnancies: 81 after in-vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) and 235 after spontaneous conception. Their data were derived from databases in a 22-year study period at the Department of Obstetrics and Gynecology, University of Szeged, Szeged, Hungary. Our results proved that the frequency of VT pregnancies was significantly higher after natural conception than after ART. A comparison of VT pregnancies demonstrated a higher rate in pregestational and gestational diabetes mellitus (GDM) in IVF/ICSI cases than in spontaneously conceived VT pregnancies. Significant differences in the prevalences of pregnancies and intrapartum complications, and adverse neonatal outcomes were observed in vanishing twins born after IVF/ICSI as compared with those born after implantation without medical assistance, suggesting that adverse perinatal outcome in IVF/ICSI VT pregnancies may be more related to ART or infertility and underlying chronic diseases. Previous induced abortion and second-trimester fetal loss indicated an increased risk of VT pregnancies, while GDM and prematurity of previous pregnancies predicted VT and growth retardation, particularly in the spontaneously conceived VT group. Diabetes is classically defined as being associated with a higher miscarriage rate. We observed a higher recurrence rate of gestational diabetes and increased incidence of pregestational and gestational diabetes mostly in IVF/ICSI VT pregnancies, suggesting that diabetes may share a pathomechanism with VT. After identifying the causes that lead to vanishing twin syndrome, GDM, chronic maternal diseases, advanced maternal age and placentation anomalies all represented independent risk factors for VT following IVF/ICSI. It can be established that the VT phenomenon was a major prognosticator of intrauterine growth restriction for the remaining fetus in VT pregnancies after ART. In conclusion, according to our results, VT is quite frequent. VT pregnancies had a lower prevalence and a worse perinatal outcome following IVF/ICSI as compared with those of their spontaneously conceived counterparts.


Medicina ◽  
2021 ◽  
Vol 57 (5) ◽  
pp. 483
Author(s):  
Brîndușa Cimpoca ◽  
Amira Moldoveanu ◽  
Nicolae Gică ◽  
Corina Gică ◽  
Anca Marina Ciobanu ◽  
...  

Heterotopic pregnancy is the condition where both intrauterine and ectopic pregnancy are present. It rarely occurs after natural conception, but is more common with assisted reproductive techniques, when more than one embryo is transferred. Quadruplet heterotopic pregnancy is exceedingly rare. Methods: A literature review was conducted aiming to highlight the diagnosis difficulties and the management options in heterotopic quadruplet pregnancies. Results: Nine relevant studies were identified by researching PubMed up to 2021 for “heterotopic quadruplet pregnancy”, “quadruplet intrauterine and ectopic pregnancy”, “synchronous intrauterine and ectopic pregnancy”. Conclusions: In this paper, we present a case of heterotopic quadruplet pregnancy and address the difficulty in diagnosing this condition and make formal recommendations.


2021 ◽  
Vol 12 (4) ◽  
pp. 240-247
Author(s):  
Mădălin-Marius Margan ◽  
Roxana Margan ◽  
Fira-Mladinescu Corneluta ◽  
Putnoky Salomeia ◽  
Tuta-Sas Ioana ◽  
...  

Objective: The aim of this paper is to illustrate the main points of interest regarding the way treatment of infertility impacts the life of couples who struggle with this condition in Romania. The unique aspects and specific challenges regarding social, financial and psychological implications that affect Romanian couples who access specialized treatment for infertility will be thoroughly discussed. Methods: This study is a descriptive cross-sectional research. The sample population included patients who attended specialized infertility treatment (Assisted Reproductive Techniques - ART) in Fertility Clinics from Romania. The study was conducted between 2017 and 2019 and data was gathered through two infertility questionnaires. Results: The questionnaire for women was filled in by 829 female participants who struggled with infertility and resorted to ART and the questionnaire for men was completed by 227 male participants, as partners of the women, some of them as well with fertility issues. We analysed the results regarding all aspects surrounding infertility and ART, such as: psychological implications, impact of stress, access to specialized treatment, costs for treatment. Conclusion: The results showed that couples who struggle with infertility have to deal with high costs for specialized infertility treatments, in addition to stress related to treatment, creating a combination which negatively impacts their future chances of getting a pregnancy.


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