scholarly journals THE POTENTIAL ADVANTAGES OF LIPID NANOPARTICLES IN TREATMENT OF ACNE

2019 ◽  
pp. 6-13
Author(s):  
Vipul Ajit Sansare ◽  
Abhijeet Mohan Kanavaje
Keyword(s):  
Film Formation ◽  
Acne Vulgaris ◽  
Physical Stability ◽  
Lipid Nanoparticles ◽  
Current Review ◽  
Acne Rosacea ◽  
Poor Patient Compliance ◽  
Common Prefix ◽  
Conventional Drug ◽  
Potential Use

Acne is a disfiguring disorder of the skin with significant cosmetic morbidity that may lead to serious psychological and social dysfunction. The skin disease comes in two forms. The most well-known form is Acne vulgaris (referred to as acne), which mostly manifests in teens but may continue into the early 20s. The second form is called Acne rosacea (referred to as rosacea) and mostly affects 30- to 60-year-olds. The two forms, despite sharing a common prefix, are quite unrelated in their respective pathophysiology, have different approaches to treatment and hence are considered two separate conditions. The conventional drug delivery system is efficient in the management of acne but poor patient compliance and adverse effects limit its efficacy. Lipid nanoparticles are novel nano lipid carriers made from biocompatible lipid which reduces toxicity; improve physical stability, skin hydration, and film formation. Furthermore, lipid nanoparticles protect the encapsulated drug from degradation. Thus current review focused on the potential use of lipid nanoparticles for the management of acne.

scholarly journals Sorafenib Repurposing for Ophthalmic Delivery by Lipid Nanoparticles: A Preliminary Study

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1956
Author(s):  
Angela Bonaccorso ◽  
Veronica Pepe ◽  
Cristina Zappulla ◽  
Cinzia Cimino ◽  
Angelo Pricoco ◽  
...  
Keyword(s):  
Uveal Melanoma ◽  
Physical Stability ◽  
Malignant Tumour ◽  
Lipid Nanoparticles ◽  
Resistance Mechanisms ◽  
Cationic Lipids ◽  
Ophthalmic Delivery ◽  
Preliminary Study ◽  
Prolonged Drug Release ◽  
Potential Use

Uveal melanoma is the second most common melanoma and the most common intraocular malignant tumour of the eye. Among various treatments currently studied, Sorafenib was also proposed as a promising drug, often administered with other compounds in order to avoid resistance mechanisms. Despite its promising cellular activities, the use of Sorafenib by oral administration is limited by its severe side effects and the difficulty to reach the target. The encapsulation into drug delivery systems represents an interesting strategy to overcome these limits. In this study, different lipid nanoparticulate formulations were prepared and compared in order to select the most suitable for the encapsulation of Sorafenib. In particular, two solid lipids (Softisan or Suppocire) at different concentrations were used to produce solid lipid nanoparticles, demonstrating that higher amounts were able to achieve smaller particle sizes, higher homogeneity, and longer physical stability. The selected formulations, which demonstrated to be biocompatible on Statens Seruminstitut Rabbit Cornea cells, were modified to improve their mucoadhesion, evaluating the effect of two monovalent cationic lipids with two lipophilic chains. Sorafenib encapsulation allowed obtaining a sustained and prolonged drug release, thus confirming the potential use of the developed strategy to topically administer Sorafenib in the treatment of uveal melanoma.

scholarly journals A review of the preparation, characterization and application of nanostructured lipid carriers

2020 ◽  
Vol 11 (1) ◽  
pp. 1130-1135 ◽  
Author(s):  
Asha Spandana K M ◽  
Jawahar Natarajan ◽  
Shailesh Thirumaleshwar ◽  
Hemanth Kumar S
Keyword(s):  
Drug Delivery ◽  
Drug Loading ◽  
Physical Stability ◽  
Pulmonary Delivery ◽  
Lipid Nanoparticles ◽  
Nanostructured Lipid Carriers ◽  
Solid Matrix ◽  
Conventional Drug ◽  
Preparation Techniques ◽  
Carrier Systems

Lipid Nanoparticles have gained increased attention during the last few decades. These carrier systems offer many advantages over conventional drug delivery system, including protection of the entrapped active ingredient from environmental (pH) or physiological (immune system, enzymes) degradations, improved bioavailability, prolonged circulation time, sustained release of drug and site specific drug delivery, reduced dose and side effects.  Solid Lipid Nanoparticles (SLN), has been reported as an alternative carrier system to liposomes.  However, SLN show some disadvantages such as drug expulsion during storage, low drug loading and aggregation of the particles. Nanostructured lipid carriers are evolved as second generation lipid nanoparticles to overcome the limitations of SLN, by modifying SLN by incorporating liquid lipid to the solid matrix for better drug accommodation to increase drug loading and prevent drug leakage while preserving the physical stability of the formulation. This article describes the features, various preparation techniques, characterization techniques and the therapeutic applications of NLCs in topical drug delivery, brain, oral and pulmonary delivery.

State of the Art on Carbonic Anhydrase Modulators for Biomedical Purposes

2019 ◽  
Vol 26 (15) ◽  
pp. 2558-2573 ◽  
Author(s):  
Murat Bozdag ◽  
Abdulmalik Saleh Alfawaz Altamimi ◽  
Daniela Vullo ◽  
Claudiu T. Supuran ◽  
Fabrizio Carta
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
State Of The Art ◽  
Cellular Level ◽  
Hydration Reaction ◽  
Carbonic Anhydrases ◽  
Crucial Importance ◽  
Learning Impairments ◽  
Current Review ◽  
Potential Use

The current review is intended to highlight recent advances in the search of new and effective modulators of the metalloenzymes Carbonic Anhydrases (CAs, EC 4.2.1.1) expressed in humans (h). CAs reversibly catalyze the CO2 hydration reaction, which is of crucial importance in the regulation of a plethora of fundamental processes at cellular level as well as in complex organisms. The first section of this review will be dedicated to compounds acting as activators of the hCAs (CAAs) and their promising effects on central nervous system affecting pathologies mainly characterized from memory and learning impairments. The second part will focus on the emerging chemical classes acting as hCA inhibitors (CAIs) and their potential use for the treatment of diseases.

Rheological and morphological characterizations on physical stability of gamma-oryzanol-loaded solid lipid nanoparticles (SLNs)

Micron ◽  
2010 ◽  
Vol 41 (1) ◽  
pp. 51-58 ◽  
Author(s):  
Nispa Seetapan ◽  
Piyawan Bejrapha ◽  
Wanwisa Srinuanchai ◽  
Uracha Rungsardthong Ruktanonchai
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Physical Stability ◽  
Lipid Nanoparticles ◽  
Solid Lipid ◽  
Gamma Oryzanol

Zastosowanie kwasu azelainowego w wybranych schorzeniach dermatologicznych

2018 ◽  
Vol 21 (4) ◽  
Author(s):  
Paula Dębek ◽  
Anna Piotrowska ◽  
Magdalena Nastałek ◽  
Natalia Totko-Borkusiewicz ◽  
Olga Czerwińska-Ledwig ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Trials ◽  
Mechanism Of Action ◽  
Azelaic Acid ◽  
Acid Treatment ◽  
Wide Spectrum ◽  
Acne Vulgaris ◽  
Acne Rosacea

Introduction. Dermatoses, such as acne vulgaris, acne rosacea and hyperpigmentations, are an increasingly common problem, their chronic character affecting the quality of life of the affected people. One of the substances with a multidirectional mechanism of action and a wide spectrum of applications is azelaic acid. Aim. The aim of this paper was to present azelaic acid as a substance suitable for treatment of many skin problems. Material and methods. The authors have analyzed the literature from 1986-2018, looking for works indicating the mechanism, effectiveness and safety of azelaic acid treatment in selected diseases. Results. This ingredient proved to meet the high requirements. Conclusions. Systematic use of azelaic acid reduces acne lesions, lightens discolorations and eliminates most of the symptoms of rosacea. It is used alone or in polytherapy, however combined therapies require further clinical trials indicating the directionality of such treatment.

scholarly journals MicroRNAs-Based Nano-Strategies as New Therapeutic Approach in Multiple Myeloma to Overcome Disease Progression and Drug Resistance

2020 ◽  
Vol 21 (9) ◽  
pp. 3084 ◽  
Author(s):  
Vanessa Desantis ◽  
Ilaria Saltarella ◽  
Aurelia Lamanuzzi ◽  
Assunta Melaccio ◽  
Antonio Giovanni Solimando ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Drug Resistance ◽  
Cancer Progression ◽  
Tumor Suppressors ◽  
Therapeutic Approach ◽  
Physical Stability ◽  
Cellular Processes ◽  
Non Coding Rnas ◽  
Potential Use ◽  
Nuclease Degradation

MicroRNAs (miRNAs, or miRs) are single-strand short non-coding RNAs with a pivotal role in the regulation of physiological- or disease-associated cellular processes. They bind to target miRs modulating gene expression at post-transcriptional levels. Here, we present an overview of miRs deregulation in the pathogenesis of multiple myeloma (MM), and discuss the potential use of miRs/nanocarriers association in clinic. Since miRs can act as oncogenes or tumor suppressors, strategies based on their inhibition and/or replacement represent the new opportunities in cancer therapy. The miRs delivery systems include liposomes, polymers, and exosomes that increase their physical stability and prevent nuclease degradation. Phase I/II clinical trials support the importance of miRs as an innovative therapeutic approach in nanomedicine to prevent cancer progression and drug resistance. Results in clinical practice are promising.

Synergistic Antitumor Efficacy of Magnetohyperthermia and Poly(lactic-co-glycolic acid)-Encapsulated Selol in Ehrlich Breast Adenocarcinoma Treatment in Elderly Swiss Mice

2020 ◽  
Vol 16 (2) ◽  
pp. 179-192 ◽  
Author(s):  
Willie O. Pinheiro ◽  
Maria L. Fascineli ◽  
Khellida L. V. Ramos ◽  
Laise R. de Andrade ◽  
Gabriel R. Farias ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Incidence ◽  
Breast Adenocarcinoma ◽  
Breast Cancer Patients ◽  
Ehrlich Tumor ◽  
Cancer Treatments ◽  
Conventional Drug ◽  
Tnf Α ◽  
Traditional Therapies ◽  
Potential Use

Nanobiotechnology strategies for cancer treatments are currently being tested with increasing interest, except in elderly groups. It is well established that breast cancer incidence increases with age and that traditional therapies usually generate severe adverse effects, especially for elderly groups. To investigate if the benefits of nanotechnology could be extended to treating cancer in this group, citrate-coated maghemite nanoparticles (NpCit) were used for magnetohyperthermia (MHT) in combination with the administration of PLGA-Selol nanocapsule (NcSel), a formulation with antioxidant and antitumor activity. The combined therapies significantly inhibited breast Ehrlich tumor growth and prevented metastases to the lymph nodes, liver and lungs until 45 days after tumor induction, a better result than the group undergoing conventional drug treatment. The levels of TNF-α, associated with poor prognosis in Ehrlich tumor, were also normalized. Therefore, the results evidenced the potential use of these therapies for future clinical trials in elderly breast cancer patients.

Controlled Release of Natural Polyphenols in Oral Cavity Using Starch Pickering Emulsion

2014 ◽  
Vol 1688 ◽  
Author(s):  
Min S. Wang ◽  
Amol Chaudhari ◽  
Yuanjie Pan ◽  
Stephen Young ◽  
Nitin Nitin
Keyword(s):  
Phase Separation ◽  
Controlled Release ◽  
Oral Cavity ◽  
Oxygen Permeability ◽  
Physical Stability ◽  
Pickering Emulsion ◽  
Natural Polyphenols ◽  
Oil In Water ◽  
Complete Disruption ◽  
Potential Use

ABSTRACTThe goal of this study was to determine the potential use of starch Pickering emulsion as a vehicle to deliver a natural phenolic compound, curcumin in the oral cavity. To this end, an oil-in-water (o/w) emulsion was prepared using starch molecules as the stabilizer/emulsifier. The physical stability, oxygen permeability and release of curcumin from the starch Pickering emulsion in simulated saliva fluid (SSF) were determined. The results of this study showed that the starch stabilized o/w emulsions were stable for up to 2 weeks. The starch Pickering emulsion also provided better protection against oxidation than a surfactant-stabilized emulsion, and the digestion of the starch Pickering emulsion using amylase led to the complete disruption and phase separation of the emulsion.

scholarly journals Case studies of enhanced pharmacodynamic activity of poorly oral bioavailable drugs via solid lipid nanoparticles

2021 ◽  
Vol 11 (2) ◽  
pp. 204-208
Author(s):  
D Raju
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Oral Absorption ◽  
Lipid Nanoparticles ◽  
Lymphatic Transport ◽  
Therapeutic Effectiveness ◽  
Therapeutic Activity ◽  
Solid Lipid ◽  
Current Review ◽  
Colloidal Carrier ◽  
Carrier Systems

Solid lipid nanoparticles (SLNs) considered as an alternative vehicle for the enhanced oral absorption of drugs, and also to enhance therapeutic effectiveness after oral administration. Pharmacodynamic activity of drug is mainly describes the pharmacological and therapeutic activity of drug to the biological system. Lipid nanoparticles especially SLNs made of physiological inert lipid molecules and helps the lymphatic transport. Numerous literatures is available on the effect of SLNs and other colloidal carrier systems on the pharmacokinetic activity of poorly bioavailable drugs, to improve their oral absorption and also respective mechanisms for the improved oral bioavailability. However, very few literatures is reported on the pharmacodynamic activity and the effect of dose on the pharmacodynamic activity. Therefore, the current review is mainly dealing with the effect of SLNs on the pharmacodynamic activity discussed.   Keywords: Oral absorption, solid lipid nanoparticles, lymphatic transport, pharmacokinetics, pharmacodynamics.

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