Deoxynivalenol and Deepoxy-Deoxynivalenol- Induced Alterations in Theca Cell Function as a Major Cause of Infertility in Dairy Cows

2021 ◽  
Vol 5 (4) ◽  
Keyword(s):  
Dairy Cows ◽  
Cell Function ◽  
Theca Cell

Effects of beta-OH Butyrate on Bovine Granulosa and Theca Cell Function in Vitro

2006 ◽  
Vol 41 (1) ◽  
pp. 39-40 ◽  
Author(s):  
T Vanholder ◽  
JLMR Leroy ◽  
A Soom ◽  
M Coryn ◽  
A Kruif ◽  
...  
Keyword(s):  
Cell Function ◽  
Theca Cell

scholarly journals Associations between Circulating IGF-1 Concentrations, Disease Status and the Leukocyte Transcriptome in Early Lactation Dairy Cows

Ruminants ◽  
2021 ◽  
Vol 1 (2) ◽  
pp. 147-177
Author(s):  
D. Claire Wathes ◽  
Frank Becker ◽  
Laura Buggiotti ◽  
Mark A. Crowe ◽  
Conrad Ferris ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dairy Cows ◽  
Cell Function ◽  
Aerobic Glycolysis ◽  
Disease Status ◽  
Global Gene Expression ◽  
Clinical Mastitis ◽  
Negative Energy ◽  
Immune Defense ◽  
Early Lactation

Peripartum dairy cows commonly experience negative energy balance (EB) and immunosuppression together with high incidences of infectious and metabolic disease. This study investigated mechanisms linking EB status with immune defense in early lactation. Data were collected from multiparous Holstein cows from six herds and leukocyte transcriptomes were analyzed using RNA sequencing. Global gene expression was related to circulating IGF-1 (as a biomarker for EB) by subdividing animals into three groups, defined as IGF-1 LOW (<35 ng/mL, n = 35), MODERATE (35–100 ng/mL, n = 92) or HIGH (>100 ng/mL, n = 43) at 14 ± 4 days in milk (DIM). Differentially expressed genes between groups were identified using CLC Genomics Workbench V21, followed by cluster and KEGG pathway analysis, focusing on the comparison between LOW and HIGH IGF-1 cows. LOW cows were older and had significantly lower dry matter intakes and EB values, whereas HIGH cows produced more milk. During the first 35 DIM, 63% of LOW cows had more than one health problem vs. 26% HIGH cows, including more with clinical mastitis and uterine infections. Gene expression analysis indicated that leukocytes in LOW cows switched energy metabolism from oxidative phosphorylation to aerobic glycolysis (PGM, LDH, and PDK4). Many antimicrobial peptides were up-regulated in LOW cows (e.g., PTX3, DMBT1, S100A8, and S100A9) together with genes associated with inflammation, platelet activation and the complement cascade. HIGH cows had greater expression of genes regulating T and B cell function and the cytoskeleton. Overall, results suggested an ongoing cycle of poor EB and higher infection rates in LOW IGF-1 cows which was reflected in altered leukocyte functionality and reduced milk production.

Effect of resistin on granulosa and theca cell function in cattle

2011 ◽  
Vol 124 (1-2) ◽  
pp. 19-27 ◽  
Author(s):  
Leon J. Spicer ◽  
Nicole B. Schreiber ◽  
Dana V. Lagaly ◽  
Pauline Y. Aad ◽  
Laura B. Douthit ◽  
...  
Keyword(s):  
Cell Function ◽  
Theca Cell

scholarly journals Effects of angiogenin on granulosa and theca cell function in cattle

animal ◽  
2017 ◽  
Vol 11 (5) ◽  
pp. 811-819 ◽  
Author(s):  
J.L. Dentis ◽  
N.B. Schreiber ◽  
A.M. Burress ◽  
L.J. Spicer
Keyword(s):  
Cell Function ◽  
Theca Cell

Effect of melatonin on bovine theca cells in vitro

2018 ◽  
Vol 30 (4) ◽  
pp. 643 ◽  
Author(s):  
T. Feng ◽  
L. F. Schutz ◽  
B. C. Morrell ◽  
M. C. Perego ◽  
L. J. Spicer
Keyword(s):  
Cell Proliferation ◽  
Cytochrome P450 ◽  
Ovarian Function ◽  
Cell Function ◽  
Regulatory Protein ◽  
Theca Cell ◽  
Theca Cells ◽  
Dependent Inhibition ◽  
Steroidogenic Acute Regulatory

Melatonin affects granulosa cell function in several species but its function in theca cells is less clear, particularly in monotocous animals. Thus, the objectives of this study were to determine the effects of melatonin on theca cell steroidogenesis, gene expression and cell proliferation in a monotocous species, namely cattle. Ovaries were collected from a local bovine abattoir, from which theca cells were isolated from large (8–22 mm) follicles and treated with various hormones in serum-free medium for 24 h or 48 h. Melatonin caused a dose-dependent inhibition (P < 0.05) of LH+insulin-like growth factor 1 (IGF1)-induced androstenedione and progesterone production. Also, melatonin inhibited (P < 0.05) LH+IGF1-induced expression of steroidogenic acute regulatory protein (StAR) mRNA (via real-time polymerase chain reaction) in theca cells, but it had no effect (P > 0.10) on cytochrome P450 11A1 (CYP11A1) and cytochrome P450 17A1 (CYP17A1) mRNA abundance. In LH+IGF1-treated theca cells, melatonin decreased caspase 3 (CASP3) mRNA to levels similar to those observed in LH-treated theca cells. In contrast, melatonin increased (P < 0.05) the number of bovine theca cells in both LH- and LH+IGF1-treated cultures. In conclusion, melatonin may act as an endocrine regulator of ovarian function in cattle by stimulating theca cell proliferation and inhibiting differentiation via inhibition of hormone-induced steroidogenesis.

scholarly journals Assessment of theca cell function prior to controlled ovarian stimulation: the predictive value of serum basal/stimulated steroid levels

2009 ◽  
Vol 25 (1) ◽  
pp. 228-234 ◽  
Author(s):  
J.-N. Hugues ◽  
L. Theron-Gerard ◽  
C. Coussieu ◽  
M. Pasquier ◽  
D. Dewailly ◽  
...  
Keyword(s):  
Ovarian Stimulation ◽  
Predictive Value ◽  
Cell Function ◽  
Theca Cell ◽  
Controlled Ovarian Stimulation

BMP-2 and -6 modulate porcine theca cell function alone and co-cultured with granulosa cells

2005 ◽  
Vol 29 (4) ◽  
pp. 593-604 ◽  
Author(s):  
Victoria Brankin ◽  
Ruth L. Quinn ◽  
Robert Webb ◽  
Morag G. Hunter
Keyword(s):  
Granulosa Cells ◽  
Cell Function ◽  
Theca Cell
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