scholarly journals A Retrospective Single Center Study Investigating the Clinical Significance of Grade in Triple Negative Breast Cancer

2021 ◽  
Vol 6 (3) ◽  
2014 ◽  
Vol 32 (15_suppl) ◽  
pp. 1123-1123
Author(s):  
Caroline M. Hamm ◽  
Maher El-Masri ◽  
Rasna Gupta ◽  
Swati Kulkarni ◽  
Akmal Ghafoor ◽  
...  

PLoS ONE ◽  
2019 ◽  
Vol 14 (1) ◽  
pp. e0208701 ◽  
Author(s):  
Seied Asadollah Mousavi ◽  
Amir Kasaeian ◽  
Maziar Pourkasmaee ◽  
Ardeshir Ghavamzadeh ◽  
Kamran Alimoghaddam ◽  
...  

2018 ◽  
Vol 21 (1) ◽  
pp. 70 ◽  
Author(s):  
Sae Byul Lee ◽  
Guiyun Sohn ◽  
Jisun Kim ◽  
Il Yong Chung ◽  
Hee Jeong Kim ◽  
...  

2017 ◽  
Vol 13 (3) ◽  
pp. 145-149 ◽  
Author(s):  
Arzu Ozsoy ◽  
Nurdan Barca ◽  
Betul Akdal Dolek ◽  
Hafize Aktas ◽  
Eda Elverici ◽  
...  

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e5344 ◽  
Author(s):  
Junnan Wang ◽  
Yiran Wang ◽  
Fei Long ◽  
Fengshang Yan ◽  
Ning Wang ◽  
...  

BackgroundGrowth arrest and DNA-damage-inducible protein 45 alpha (GADD45A) was previously found to be associated with risk of several kinds of human tumors. Here, we studied the expression and clinical significance of GADD45A in breast cancer.MethodsWe performed an immunohistochemical study of GADD45A protein from 419 breast cancer tissues and 116 adjacent non-neoplastic tissues.ResultsSignificantly high GADD45A expression were observed in breast cancer tissues compared with adjacent non-neoplastic tissues (P < 0.001) and were independently correlative with estrogen receptor negative (P = 0.028) and high Ki-67 index (P < 0.001). Kaplan–Meier survival analysis revealed that patients with high GADD45A expression levels had a worse long-term prognosis in triple negative breast cancer (P = 0.041), but it was not an independent prognostic factor in multivariate analysis (P = 0.058).ConclusionsGADD45A expression levels are significantly correlative with estrogen receptor status and Ki-67 index in human breast cancer. Patients with triple negative breast cancer might be stratified into high risk and low risk groups based on the GADD45A expression levels.


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