scholarly journals Adjuvant chemotherapy for small, lymph node–negative, triple‐negative breast cancer: A single‐center study and a meta‐analysis of the published literature

Cancer ◽  
2020 ◽  
Vol 126 (S16) ◽  
pp. 3837-3846
Author(s):  
Xin An ◽  
Xuefen Lei ◽  
Riqing Huang ◽  
Rongzhen Luo ◽  
Haifeng Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Adjuvant Chemotherapy ◽  
Triple Negative ◽  
Meta Analysis ◽  
Single Center ◽  
Node Negative ◽  
Single Center Study ◽  
Small Lymph Node ◽  
Center Study

Outcomes of patients with triple-negative breast cancer compared to non-triple negative breast cancer: A single-center study.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. 1123-1123
Author(s):  
Caroline M. Hamm ◽  
Maher El-Masri ◽  
Rasna Gupta ◽  
Swati Kulkarni ◽  
Akmal Ghafoor ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Single Center ◽  
Single Center Study ◽  
Center Study

scholarly journals The role of capecitabine-based neoadjuvant and adjuvant chemotherapy in early-stage triple-negative breast cancer: a systematic review and meta-analysis

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xingfa Huo ◽  
Jinming Li ◽  
Fuxing Zhao ◽  
Dengfeng Ren ◽  
Raees Ahmad ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Adjuvant Chemotherapy ◽  
Triple Negative Breast Cancer ◽  
Randomized Clinical Trials ◽  
Triple Negative ◽  
Early Stage ◽  
Meta Analysis ◽  
Disease Free Survival

Abstract Background The role of capecitabine in neoadjuvant and adjuvant chemotherapy for early-stage triple-negative breast cancer (TNBC) is highly controversial. Our meta-analysis was designed to further elucidate the effects of capecitabine on survival in early-stage TNBC patients and its safety. Methods PubMed, Embase, and papers presented at several main conferences were searched up to December 19, 2019, to investigate capecitabine-based versus capecitabine-free neoadjuvant and adjuvant chemotherapy in TNBC patients. Heterogeneity was assessed using I2 test, combined with hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CI) computed for disease-free survival (DFS), overall survival (OS), and over grade 3 adverse events (AEs). Results A total of 9 randomized clinical trials and 3842 TNBC patients were included. Overall, the combined capecitabine regimens in neoadjuvant and adjuvant chemotherapy showed significantly improved DFS (HR = 0.75; 95% CI, 0.65–0.86; P < 0.001) and OS (HR = 0.63; 95% CI, 0.53–0.77; P < 0.001). In subgroup analysis, there were improvements in DFS in the groups with addition of capecitabine (HR = 0.64; 95% CI, 0.53–0.78; P < 0.001), adjuvant chemotherapy (HR = 0.73; 95% CI, 0.63–0.85; P < 0.001), and lymph node positivity (HR = 0.62; 95% CI, 0.44–0.86; P = 0.005). Capecitabine regimens were related to higher risks of diarrhea (OR = 2.88, 95% CI 2.23–3.74, P < 0.001), stomatitis (OR = 2.01, 95% CI 1.53–2.64, P < 0.001) and hand–foot syndrome (OR = 8.67, 95% CI 6.70–11.22, P < 0.001). Conclusion This meta-analysis showed that neoadjuvant and adjuvant chemotherapy combined with capecitabine significantly improved both DFS and OS in early-stage TNBC patients with tolerable AEs. There were benefits to DFS in the groups with the addition of capecitabine, adjuvant chemotherapy, and lymph node positivity.

scholarly journals Assessing the prognostic factors, survival, and recurrence incidence of triple negative breast cancer patients, a single center study in Iran

PLoS ONE ◽  
2019 ◽  
Vol 14 (1) ◽  
pp. e0208701 ◽  
Author(s):  
Seied Asadollah Mousavi ◽  
Amir Kasaeian ◽  
Maziar Pourkasmaee ◽  
Ardeshir Ghavamzadeh ◽  
Kamran Alimoghaddam ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Cancer Patients ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Breast Cancer Patients ◽  
Single Center ◽  
Single Center Study ◽  
Center Study

scholarly journals Patterns of Axillary Lymph Node Metastasis in Breast Cancer: A Prospective Single-Center Study

2018 ◽  
Vol 21 (4) ◽  
pp. 447
Author(s):  
Hee Jun Choi ◽  
Jae-Myung Kim ◽  
Jai Min Ryu ◽  
Isaac Kim ◽  
Seok Jin Nam ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Axillary Lymph Node ◽  
Axillary Lymph Node Metastasis ◽  
Axillary Lymph ◽  
Single Center ◽  
Node Metastasis ◽  
Single Center Study ◽  
Center Study

scholarly journals Chronological Improvement in Survival of Patients with Breast Cancer: A Large-Scale, Single-Center Study

2018 ◽  
Vol 21 (1) ◽  
pp. 70 ◽  
Author(s):  
Sae Byul Lee ◽  
Guiyun Sohn ◽  
Jisun Kim ◽  
Il Yong Chung ◽  
Hee Jeong Kim ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Large Scale ◽  
Single Center ◽  
Single Center Study ◽  
Improvement In Survival ◽  
Center Study

scholarly journals The Relationship Between Breast Cancer and Risk Factors: A Single-Center Study

2017 ◽  
Vol 13 (3) ◽  
pp. 145-149 ◽  
Author(s):  
Arzu Ozsoy ◽  
Nurdan Barca ◽  
Betul Akdal Dolek ◽  
Hafize Aktas ◽  
Eda Elverici ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Single Center ◽  
Single Center Study ◽  
The Relationship ◽  
Center Study
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