scholarly journals The protective effect of prostaglandin E1 on experimentally-induced acute hepatic failure.

Kanzo ◽  
1987 ◽  
Vol 28 (4) ◽  
pp. 433-438
Author(s):  
Yasuhiro MIZOGUCHI ◽  
Hiroko TSUTSUI ◽  
Hiroshi KUBOI ◽  
Jae-Dam LEE ◽  
Yumiko FUJINOBU ◽  
...  
Keyword(s):  
Protective Effect ◽  
Hepatic Failure ◽  
Prostaglandin E1 ◽  
Acute Hepatic Failure ◽  
Experimentally Induced

scholarly journals Effects of Lipo prostaglandin E1 in an experimentally-induced acute hepatic failure model.

Ensho ◽  
1990 ◽  
Vol 10 (2) ◽  
pp. 115-118
Author(s):  
Yasuhiro Mizoguchi ◽  
Hiroshi Kuboi ◽  
Norifumi Kawada ◽  
Kenzo Kobayashi ◽  
Seiji Morisawa
Keyword(s):  
Hepatic Failure ◽  
Prostaglandin E1 ◽  
Acute Hepatic Failure ◽  
Failure Model ◽  
Experimentally Induced

An experimentally-induced acute hepatic failure model in various strains of mice

1989 ◽  
Vol 24 (5) ◽  
pp. 519-522 ◽  
Author(s):  
Yasuhiro Mizoguchi ◽  
Hiroshi Kuboi ◽  
Hiroko Tsutsui ◽  
Shuichi Seki ◽  
Kenzo Kobayashi ◽  
...  
Keyword(s):  
Hepatic Failure ◽  
Acute Hepatic Failure ◽  
Failure Model ◽  
Experimentally Induced

Effect of prostaglandin E1 on experimental acute hepatic failure in rabbits: prostaglandin E1 prevents the development of multiple-organ failure

1994 ◽  
Vol 20 (4) ◽  
pp. 478-482 ◽  
Author(s):  
Eiryo Kikuchi ◽  
Hiroshi Fukui ◽  
Masami Matsumoto ◽  
Shigenobu Tsujita ◽  
Munesuke Matsumoto ◽  
...  
Keyword(s):  
Multiple Organ Failure ◽  
Organ Failure ◽  
Hepatic Failure ◽  
Prostaglandin E1 ◽  
Acute Hepatic Failure ◽  
Multiple Organ

Problems in Treating Experimentally Induced Acute Hepatic Failure by Hemoperfusion or Cross Circulation

Hepatology ◽  
2007 ◽  
Vol 3 (5) ◽  
pp. 696-700 ◽  
Author(s):  
Robert A. F. M. Chamuleau ◽  
Robert J. Popken ◽  
Ellen C. Beyerbacht ◽  
Henk W. M. De Koning
Keyword(s):  
Hepatic Failure ◽  
Acute Hepatic Failure ◽  
Experimentally Induced

Protective effect of N-acetylcysteine and deferoxamine on carbon tetrachloride-induced acute hepatic failure in rats

2004 ◽  
Vol 32 (10) ◽  
pp. 2079-2083 ◽  
Author(s):  
Cristiane Ritter ◽  
Adalisa Reinke ◽  
Michael Andrades ◽  
Márcio Rodrigo Martins ◽  
João Rocha ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Protective Effect ◽  
Hepatic Failure ◽  
Acute Hepatic Failure

Effects of irsoglandine maleate in an experimentally-induced acute hepatic failure model using mice

1991 ◽  
Vol 26 (2) ◽  
pp. 177-181 ◽  
Author(s):  
Yasuhiro Mizoguchi ◽  
Norifumi Kawada ◽  
Yuzo Ichikawa ◽  
Kenzo Kobayashi ◽  
Seiji Morisawa
Keyword(s):  
Hepatic Failure ◽  
Acute Hepatic Failure ◽  
Failure Model ◽  
Experimentally Induced

scholarly journals Protective Effect of Danhong Injection on Acute Hepatic Failure Induced by Lipopolysaccharide and D-Galactosamine in Mice

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Ying Wang ◽  
Li-Na Gao ◽  
Yuan-Lu Cui ◽  
Heng-Li Jiang
Keyword(s):  
Protective Effect ◽  
Hepatic Failure ◽  
Interleukin 1 ◽  
Acute Hepatic Failure ◽  
Serum Levels ◽  
Histopathological Analysis ◽  
Potential Candidate ◽  
Glutathione S Transferase ◽  
Danhong Injection ◽  
Hepatic Lipid Peroxidation

Acute hepatic failure (AHF), which leads to an extremely high mortality rate, has become the focus of attention in clinic. In this study, Danhong injection (DHI) was investigated to evaluate the preventive and protective effect on AHF induced by lipopolysaccharide (LPS) and D-galactosamine (GalN) in mice. For AHF induction, ICR mice were intraperitoneally injected with D-GalN (700 mg/kg) and LPS (20 μg/kg). DHI was administrated twice, at 12 and 1 h, respectively, before D-GalN/LPS injection. After stimulation with D-GalN/LPS for 1 and 6 h, serum and livers were collected for analysis. We found that mice administrated with DHI displayed a higher survival rate, lower serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBil), glutathione S-transferase (GST), and tumor necrosis factor (TNF)-α. DHI inhibited the elevations of hepatic lipid peroxidation (malondialdehyde), caspase-8 activity, and mRNA expression levels of inflammatory cytokines (interleukin-1βand interleukin-6) increased by D-GalN/LPS in the liver. Furthermore, liver histopathological analysis indicated that the DHI group showed markedly fewer apoptotic (TUNEL positive) cells and less pathological changes than those in the AHF model group. These results provide a novel insight into the pharmacological actions of DHI as a potential candidate for treating AHF.

scholarly journals Effects of an immunostimulant, OK432, in an experimentally-induced acute hepatic failure model.

Kanzo ◽  
1988 ◽  
Vol 29 (8) ◽  
pp. 1038-1042
Author(s):  
Yasuhiro MIZOGUCHI ◽  
Hiroshi KUBOI ◽  
Yoshihide SAKAGAMI ◽  
Shuichi SEKI ◽  
Kenzo KOBAYASHI ◽  
...  
Keyword(s):  
Hepatic Failure ◽  
Acute Hepatic Failure ◽  
Failure Model ◽  
Experimentally Induced
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