Protective effect of bicyclol on acute hepatic failure induced by lipopolysaccharide and d-galactosamine in mice

2006 ◽  
Vol 534 (1-3) ◽  
pp. 194-201 ◽  
Author(s):  
Huiping Wang ◽  
Yan Li
Keyword(s):  
Protective Effect ◽  
Hepatic Failure ◽  
Acute Hepatic Failure

scholarly journals The protective effect of prostaglandin E1 on experimentally-induced acute hepatic failure.

Kanzo ◽  
1987 ◽  
Vol 28 (4) ◽  
pp. 433-438
Author(s):  
Yasuhiro MIZOGUCHI ◽  
Hiroko TSUTSUI ◽  
Hiroshi KUBOI ◽  
Jae-Dam LEE ◽  
Yumiko FUJINOBU ◽  
...  
Keyword(s):  
Protective Effect ◽  
Hepatic Failure ◽  
Prostaglandin E1 ◽  
Acute Hepatic Failure ◽  
Experimentally Induced

Protective effect of N-acetylcysteine and deferoxamine on carbon tetrachloride-induced acute hepatic failure in rats

2004 ◽  
Vol 32 (10) ◽  
pp. 2079-2083 ◽  
Author(s):  
Cristiane Ritter ◽  
Adalisa Reinke ◽  
Michael Andrades ◽  
Márcio Rodrigo Martins ◽  
João Rocha ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Protective Effect ◽  
Hepatic Failure ◽  
Acute Hepatic Failure

scholarly journals Protective Effect of Danhong Injection on Acute Hepatic Failure Induced by Lipopolysaccharide and D-Galactosamine in Mice

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Ying Wang ◽  
Li-Na Gao ◽  
Yuan-Lu Cui ◽  
Heng-Li Jiang
Keyword(s):  
Protective Effect ◽  
Hepatic Failure ◽  
Interleukin 1 ◽  
Acute Hepatic Failure ◽  
Serum Levels ◽  
Histopathological Analysis ◽  
Potential Candidate ◽  
Glutathione S Transferase ◽  
Danhong Injection ◽  
Hepatic Lipid Peroxidation

Acute hepatic failure (AHF), which leads to an extremely high mortality rate, has become the focus of attention in clinic. In this study, Danhong injection (DHI) was investigated to evaluate the preventive and protective effect on AHF induced by lipopolysaccharide (LPS) and D-galactosamine (GalN) in mice. For AHF induction, ICR mice were intraperitoneally injected with D-GalN (700 mg/kg) and LPS (20 μg/kg). DHI was administrated twice, at 12 and 1 h, respectively, before D-GalN/LPS injection. After stimulation with D-GalN/LPS for 1 and 6 h, serum and livers were collected for analysis. We found that mice administrated with DHI displayed a higher survival rate, lower serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBil), glutathione S-transferase (GST), and tumor necrosis factor (TNF)-α. DHI inhibited the elevations of hepatic lipid peroxidation (malondialdehyde), caspase-8 activity, and mRNA expression levels of inflammatory cytokines (interleukin-1βand interleukin-6) increased by D-GalN/LPS in the liver. Furthermore, liver histopathological analysis indicated that the DHI group showed markedly fewer apoptotic (TUNEL positive) cells and less pathological changes than those in the AHF model group. These results provide a novel insight into the pharmacological actions of DHI as a potential candidate for treating AHF.

Applying the Principles of Bridging Therapy at Concomitant Acute Hepatic Failure

2016 ◽  
Vol 0 (3.74) ◽  
pp. 112
Author(s):  
I.A. Kuchinskaya ◽  
M.V. Bondar ◽  
D.B. Areshnikov ◽  
S.S. Shapoval ◽  
R.D. Dobush
Keyword(s):  
Hepatic Failure ◽  
Acute Hepatic Failure ◽  
Bridging Therapy

scholarly journals Treatment of acute hepatic failure and encephalopathy with extracorporeal ex vivo pig-liver perfusion in the critical care unit

Critical Care ◽  
10.1186/cc560 ◽  
1999 ◽  
Vol 3 (Suppl 1) ◽  
pp. P187
Author(s):  
MC DaSilva ◽  
M Gupta ◽  
MJ Holman ◽  
HG Yang ◽  
RL Conter ◽  
...  
Keyword(s):  
Critical Care ◽  
Hepatic Failure ◽  
Critical Care Unit ◽  
Ex Vivo ◽  
Liver Perfusion ◽  
Acute Hepatic Failure ◽  
Pig Liver

Acute Hepatic Failure in Swine: Hepatectomy Versus Vascular Occlusion

2004 ◽  
Vol 17 (3) ◽  
pp. 163-171 ◽  
Author(s):  
Nils R. Frühauf ◽  
Karl J. Oldhafer ◽  
Stephanie Westermann ◽  
Georgios C. Sotiropoulos ◽  
Gernot M. Kaiser
Keyword(s):  
Hepatic Failure ◽  
Vascular Occlusion ◽  
Acute Hepatic Failure

Acute Fulminant Hepatic Failure in a Woman Treated With Phenytoin and Trimethoprim-Sulfamethoxazole

2000 ◽  
Vol 124 (12) ◽  
pp. 1800-1803 ◽  
Author(s):  
Marius J-M. Ilario ◽  
Jose E. Ruiz ◽  
Constantine A. Axiotis
Keyword(s):  
Liver Injury ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Fulminant Hepatic Failure ◽  
Hepatic Failure ◽  
Acute Hepatic Failure ◽  
Hepatic Necrosis ◽  
Rare Occurrence ◽  
Autopsy Findings ◽  
Massive Hepatic Necrosis

Abstract Massive hepatic necrosis following exposure to phenytoin and trimethoprim-sulfamethoxazole is a rare occurrence and to the best of our knowledge has not been reported previously. Acute hepatic failure following administration of trimethoprim-sulfamethoxazole has rarely been seen, and only 4 cases have been well documented pathologically. We report a case of acute liver failure in a 60-year-old woman following ingestion of phenytoin and trimethoprim-sulfamethoxazole concomitantly over a 9-day period. Autopsy findings revealed acute fulminant hepatic failure. This case demonstrates the effects of chemical-chemical interactions in the potentiation of hepatotoxicity of single agents and specifically illustrates the need for discontinuing trimethoprim-sulfamethoxazole in the presence of early liver injury.

scholarly journals Fatal neurological complication after liver transplantation in acute hepatic failure patient with hepatic encephalopathy

2018 ◽  
Vol 33 (1) ◽  
pp. 96
Author(s):  
Joo-Yun Kim ◽  
Hyun-Su Ri ◽  
Ji-Uk Yoon ◽  
Eun-Ji Choi ◽  
Hye-Jin Kim ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Hepatic Encephalopathy ◽  
Hepatic Failure ◽  
Neurological Complication ◽  
Acute Hepatic Failure
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