scholarly journals Clinical Significance of Oligohydramnios in Patients with Preterm Premature Rupture of Membranes

2021 ◽  
Vol 6 (2) ◽  
pp. 9-15
Author(s):  
O. M. Chistyakova ◽  
L. V. Gureeva ◽  
O. V. Radkov
Keyword(s):  
Neonatal Intensive Care ◽  
Perinatal Outcomes ◽  
Main Group ◽  
Control Group ◽  
C Reactive Protein ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Amniotic Fluid Index ◽  
Reactive Protein ◽  
Preterm Premature Rupture

Background. Preterm premature rupture of membranes (PPROM) is one of the main causes of perinatal morbidity and mortality. Associated oligohydramnios may further exacerbate the condition leading to intra-amniotic inflammation and adverse obstetric and perinatal outcomes in preterm labor.Aim of the research. To determine an impact of oligohydramnios on patients with preterm premature rupture of membranes.Materials and methods. We performed a retrospective analysis of two groups of patients with PPROM: 56 patients with oligohydramnios were included in the main group, 111 patients without oligohydramnios were included in the control group. The gestational age varied from 24+0 weeks to 33+6 weeks. Amniotic fluid index, endocervical culture, leukogram and neutrophil-to-lymphocyte ratio (NLR), serum procalcitonin and C-reactive protein levels were assessed in all participants.Results. We witnessed a plethora of consequences in the group of women with PPROM and oligohydramnios: shorter latent phase, higher incidence of clinical chorioamnionitis, antenatal fetal distress, higher levels of C-reactive protein, leukocytes, neutrophils and NLR, lower level of lymphocytes, and increased growth of potentially pathogenic cervical flora. Moreover, the patients with oligohydramnios demonstrated a significantly higher rate of cesarean delivery. The combination of PPROM and oligohydramnios also take a toll on the condition of the newborns: they have lower 5-minute Apgar score and higher prevalence of respiratory distress syndrome, congenital pneumonia, and necrotizing enterocolitis. Furthermore, newborns from the main group are more likely to be admitted to the neonatal intensive care unit, compared with newborns from the control group.Conclusion. Oligohydramnios in PPROM is associated with a dramatic rise of numerous complications affecting both the women and the newborns. 

scholarly journals Effect of antibiotics on inflammatory marker (IL-6) and perinatal outcomes in women with preterm premature rupture of membranes

2018 ◽  
Vol 7 (10) ◽  
pp. 4068
Author(s):  
Ashima Arora ◽  
Ratna Biswas ◽  
Bhawna Dubey ◽  
Binita Goswami ◽  
Sonal Saxena
Keyword(s):  
Neonatal Sepsis ◽  
Neonatal Intensive Care ◽  
Inflammatory Marker ◽  
Perinatal Outcomes ◽  
Admission Rate ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Preterm Premature Rupture ◽  
Adverse Perinatal Outcomes ◽  
High Level

Background: The aim is to study the effect of antibiotics on inflammatory marker (IL-6) and perinatal outcomes in women with preterm premature rupture of membranes (PPROM).Methods: 60 women with PPROM at 28–34 weeks of gestation were enrolled in the study. All the women were given antibiotics as per hospital protocol and were subjected to blood sampling for Interleukin -6(IL-6) at admission, delivery and umbilical cord blood. IL-6 levels were assessed for associations with adverse perinatal outcomes and the effect of antibiotic treatment on IL-6 and perinatal outcomes were studied. The data were analyzed using t test and χ2 test.Results: Increased level of IL-6 was associated with chorioamnionitis and neonatal sepsis (p<0.001). High level of IL-6 led to early delivery and complete course of antibiotics suppressed IL-6 (p<0.001) and clinical chorioamnionitis in women with PROM. Full course of antibiotics also decreased the admission rate of babies to neonatal intensive care unit and suppressed respiratory distress syndrome, neonatal sepsis.Conclusions: Increased level of IL-6 is seen in women with chorioamnionitis and neonatal sepsis. Antibiotics suppress the IL-6 levels, chorioamnionitis and neonatal sepsis.

Serum highly sensitive C-reactive protein in preterm premature rupture of membranes

2003 ◽  
Vol 110 (1) ◽  
pp. 26-28 ◽  
Author(s):  
Mikko J. Loukovaara ◽  
Henrik V. Alfthan ◽  
M.Tapio Kurki ◽  
Vilho K. Hiilesmaa ◽  
Sture H.M. Andersson
Keyword(s):  
C Reactive Protein ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Reactive Protein ◽  
Preterm Premature Rupture ◽  
Highly Sensitive

scholarly journals The Effect of Transabdominal Amnioinfusion on Perinatal Outcomes in Preterm Premature Rupture of Membranes

2014 ◽  
Vol 6 (1) ◽  
pp. 28-32
Author(s):  
Nasira Tasnim ◽  
Ghazala Mahmud ◽  
Saba Fatima
Keyword(s):  
Controlled Trial ◽  
Latency Period ◽  
Perinatal Outcomes ◽  
Expectant Management ◽  
Management Control ◽  
Control Group ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Preterm Premature Rupture ◽  
Significant Prolongation

ABSTRACT Objective To evaluate the role of transabdominal amnioinfusion in improving the latency period and perinatal outcomes of pregnancies complicated by preterm premature rupture of membranes (PPROM). Materials and methods A randomized controlled trial was carried out at MCH Centre, Unit I, PIMS, Islamabad, from Jan 2008 to Dec 2008. Sixty women with singleton pregnancies between 28 and 32 completed weeks of gestation, complicated with PPROM was randomly allocated into two groups viz transabdominal amnioinfusion (amnioinfusion group) and expectant management (control group), within 24 hours of admission. Results The demographic characteristics were comparable in both the groups. Amnioinfusion group showed significant improvement in PPROM to delivery interval (18.47 ± 6.699 vs 8.93 ± 4.741 days; p = 0.001), neonatal birth weight (p = 0.019) and Apgar scores at 1 and 5 minutes (p = 0.007 for 1 minute and p = 0.012 for 5 minutes). There was less frequency of respiratory distress syndrome (p = 0.032), neonatal sepsis (p = 0.020) and neonatal jaundice (p = 0.002) in the amnioinfusion group. Fewer neonates were admitted to NICU (p = 0.010) and higher survival rate was found in amnioinfusion group (p = 0.023). Conclusion The treatment with transabdominal amnioinfusion in pregnancies complicated with PPROM resulted in significant prolongation of pregnancy and better neonatal outcomes as compared to women who were managed with traditional expectant management. How to cite this article Fatima S, Tasnim N, Mahmud G. The Effect of Transabdominal Amnioinfusion on Perinatal Outcomes in Preterm Premature Rupture of Membranes. J South Asian Feder Obst Gynae 2014;6(1):28-32.

C-reactive protein in vaginal fluid of patients with preterm premature rupture of membranes

2003 ◽  
Vol 82 (12) ◽  
pp. 1072-1079 ◽  
Author(s):  
Edoardo Di Naro ◽  
Fabio Ghezzi ◽  
Luigi Raio ◽  
Francesco Romano ◽  
Michel D. Mueller ◽  
...  
Keyword(s):  
Vaginal Fluid ◽  
C Reactive Protein ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Reactive Protein ◽  
Preterm Premature Rupture

Maternal C-Reactive Protein at Hospital Admission Is a Simple Predictor of Funisitis in Preterm Premature Rupture of Membranes

2012 ◽  
Vol 74 (2) ◽  
pp. 95-99 ◽  
Author(s):  
Giuseppina Perrone ◽  
Maurizio M. Anceschi ◽  
Oriana Capri ◽  
Paola Galoppi ◽  
Sabrina Pizzulo ◽  
...  
Keyword(s):  
Hospital Admission ◽  
C Reactive Protein ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Reactive Protein ◽  
Preterm Premature Rupture
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