scholarly journals Somatometric and Index Indicators for Assessing the Physical State of Patients with Gastric Cancer

2019 ◽  
Vol 3 (6) ◽  
pp. 77-81
Author(s):  
Е. A. Gorbunova ◽  
N. N. Medvedeva ◽  
G. N. Filkin
Keyword(s):  
Gastric Cancer ◽  
Stomach Cancer ◽  
Physical State ◽  
The Elderly ◽  
Overweight And Obesity ◽  
Cancer Development ◽  
Physical Status ◽  
Gender Dimorphism ◽  
Increased Risk ◽  
Sex Inversion

The purpose of the research was to study physical health of patients with gastric cancer, the identification of markerspredictors of gastric cancer.Material and methods. This article presents the results of a survey with 150 patients diagnosed with stomach cancer. The research was conducted on the basis of the department of oncoabdominal surgery of Krasnoyarsk Regional Clinical Oncological Hospital named after A.I. Kryzhanovskiy in the period from 2016 to 2017. Patients with established gastric cancer, awaiting for surgical treatment, were examined using anthropometric methods of research. We evaluated the physical status of patients of different age diagnosed with stomach cancer. We also calculated body mass index and Tanner’s index of sexual dimorphism (1968), according to the last we determined the type of gender dimorphism. Distribution of healthy men and women in the population of the Krasnoyarsk Territory was taken for comparison.Results. We have obtained the following markers: overweight and obesity, sex inversion in men of the II period of adulthood and the elderly to gynecomorphy, and in women of the II period of adulthood – to mesomorphy.Conclusions. These markers are used for assessment of the physical status of patients with stomach cancer. They, together with the already known risk factors of gastric cancer development, will help to identify groups with an increased risk for gastric cancer development at the stage of medical examination of the population.

Pathophysiology of intestinal metaplasia of the stomach: emphasis on CDX2 regulation

2010 ◽  
Vol 38 (2) ◽  
pp. 358-363 ◽  
Author(s):  
Rita Barros ◽  
Vânia Camilo ◽  
Bruno Pereira ◽  
Jean-Noel Freund ◽  
Leonor David ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Intestinal Metaplasia ◽  
De Novo ◽  
Current Knowledge ◽  
Regulatory Mechanisms ◽  
Cancer Development ◽  
Molecular Pathways ◽  
Neoplastic Lesion ◽  
Increased Risk

IM (intestinal metaplasia) of the stomach is a pre-neoplastic lesion that usually follows Helicobacter pylori infection and that confers increased risk for gastric cancer development. After setting the role played by CDX2 (Caudal-type homeobox 2) in the establishment of gastric IM, it became of foremost importance to unravel the regulatory mechanisms behind its de novo expression in the stomach. In the present paper, we review the basic pathology of gastric IM as well as the current knowledge on molecular pathways involved in CDX2 regulation in the gastric context.

LIVING AND HEALTH CONDITIONS ASSOCIATED WITH OVERWEIGHT AND OBESITY AMONG ELDERLY

2015 ◽  
pp. 1-9
Author(s):  
B.F. DO NASCIMENTO JACINTO DE SOUZA ◽  
L. MARÍN-LEON
Keyword(s):  
Chronic Diseases ◽  
Eating Behaviors ◽  
Multinomial Logistic Regression ◽  
The Elderly ◽  
Cross Sectional Study ◽  
Overweight And Obesity ◽  
Related Factors ◽  
Cross Sectional ◽  
Increased Risk ◽  
Health Related

Background: The epidemiological and nutritional transition processes in the last decades underlie the rising trend of obesity in the elderly and is related to increased risk of chronic non-communicable diseases and decreased functional status. Objective: To analyze the association of demographic, socioeconomic, lifestyle and health-related factors with overweight and obesity in elderly. Design: Cross-sectional study. Setting: Carried out in Campinas-São Paulo, Brazil, in 2011. Participants: 452 non-institutionalized elderly (aged ≥60 years), half were users of a government-run soup kitchen and the other half were neighbors of the same sex. Results:Overweight frequency (BMI ≥25 and <30 kg/m2) was 44.5% and obesity (BMI ≥30 kg/m2) was 21.7%. In the multiple multinomial logistic regression model adjusted for sex, age group and economic class, there was greater chance of overweight among those that reported dyslipidemia; those that reported arthritis/ arthrosis/rheumatism and that once or more per week replaced supper by a snack were more likely to be obese. Elderly who did not leave home daily and reported diabetes had higher chance of overweight and obesity. Conclusions: Overweight and obesity are associated with worse living and health-related conditions, such as physical inactivity, changes in eating behaviors, and chronic diseases. Public health policies should encourage regular physical activity and healthy eating behaviors, focusing on traditional diet, through nutritional education, in order to reduce the prevalence of overweight and obesity and chronic diseases.

Is the ABCB1 Gene Associated with the Increased Risk of Gastric Cancer Development?—Preliminary Research

2014 ◽  
Vol 210 (12) ◽  
pp. 872-878 ◽  
Author(s):  
M. Zebrowska ◽  
A. Salagacka ◽  
A. Jelen ◽  
D. Jesionek-Kupnicka ◽  
M. Mirowski ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Development ◽  
Abcb1 Gene ◽  
Increased Risk ◽  
Preliminary Research

Body mass index and white matter lesions in elderly women. An 18-year longitudinal study

2004 ◽  
Vol 16 (3) ◽  
pp. 327-336 ◽  
Author(s):  
D. R. Gustafson ◽  
B. Steen ◽  
I. Skoog
Keyword(s):  
Body Mass Index ◽  
White Matter ◽  
Body Mass ◽  
Elderly Women ◽  
White Matter Lesions ◽  
Vascular Risk Factor ◽  
The Elderly ◽  
Overweight And Obesity ◽  
Increased Risk ◽  
Blood Pressures

Background: We investigated the longitudinal relationship between body mass index (BMI), a major vascular risk factor, and white matter lesions (WMLs) in older women.Methods: Twenty-seven Swedish women were followed from age 70 to 88. Measurements of BMI, and systolic and diastolic blood pressures were conducted at 70, 75, 79, 85, and 88 years. WMLs were measured using computerized tomography at age 85 and 88 (85/88).Results: Women with any WMLs at age 85/88 had higher BMI at age 70 (p=0.003) and 75 (p=0.006), compared to women without WMLs. Increasing severity of WMLs was related to BMI at age 70 (p<0.001), 75 (p<0.001), 79 (p=0.017), and 85 (p=0.025). After consideration of other vascular factors, BMI at age 70, 75, and 79 was most significantly related to WML at 85/88. Every 1.0 kg/m2 increase in BMI at age 70 increased risk of WMLs twofold.Conclusions: Overweight and obesity may be important contributors to the presence of WMLs in the elderly.

scholarly journals ANTHROPOMETRIC AND BIO-IMPEDANSOMETRIC PARAMETERS AS DIAGNOSTIC PREDICTORS IN PATIENTS WITH GASTRIC CANCER

2021 ◽  
Vol 28 (4) ◽  
pp. 18-24
Author(s):  
Ekaterina A. Gorbunova ◽  
Armen R. Karakhanyan ◽  
Yana A. Yankina ◽  
Nadezhda N. Medvedeva ◽  
Ruslan A. Zukov
Keyword(s):  
Gastric Cancer ◽  
Stomach Cancer ◽  
Discriminant Function ◽  
Statistical Significance ◽  
Men And Women ◽  
Cancer Group ◽  
Increased Risk ◽  
Shoulder Diameter ◽  
Discriminant Models

The study of anthropometric and bioimpedance parameters in assessing the physical development of patients helps to clarify the diagnosis, predict the course of the disease, and identify groups of increased risk for the development of the disease. The aim of this study was to identify anthropometric and bioimpedance metrics in patients with stomach cancer. Anthropometric and bioimpedansometric examination of 250 patients with verified gastric cancer, 123 men and 127 women was carried out. As a comparison group, the study used the results of anthropometric and bioimpedance measurements of healthy 221 men and 267 women of the same age in the Krasnoyarsk Territory population. To determine a set of anthropometric and bioimpedansometric variables, allowing to classify the observed people depending on the presence (group of patients with gastric cancer) or the absence of stomach cancer (group of healthy people), the method of discriminant analysis was applied. To test the hypothesis about the homogeneity of the covariance matrices of the compared groups, the multidimensional Box M-criterion was used. The statistical significance of the power of the discriminant function was assessed using the Wilks test. For each discriminant function, the role of its components was assessed by comparing the matrices of total variances and covariances using the F-test. Shoulder diameter for men and women, chest diameter (transverse size) for men and women, waist circumference for men, waist / hip ratio for men and women; lean mass in men, total fluid in men, fat mass in women, phase angle in men and women are statistically significantly different in the observed groups. The developed discriminant models with an accuracy of 75-77% suggest the presence of gastric cancer in patients and can be used in clinical practice at the stage of general medical examination in groups at increased risk of developing the disease.

scholarly journals Endoscopic Submucosal Dissection for Early Gastric Cancer in Elderly vs. Non-Elderly Patients: A Systematic Review and Meta-Analysis

2022 ◽  
Vol 11 ◽  
Author(s):  
Jiting Zhao ◽  
Zhen Sun ◽  
Junwei Liang ◽  
Song Guo ◽  
Di Huang
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Elderly Patients ◽  
Subgroup Analysis ◽  
Meta Analysis ◽  
The Elderly ◽  
Complete Resection ◽  
En Bloc ◽  
Increased Risk ◽  
Significant Difference

ObjectiveThis study aimed to review the applicability and complications rate associated with endoscopic submucosal dissection (ESD) for early gastric cancer in elderly patients.MethodsDatabases of PubMed, Embase, CENTRAL, and ScienceDirect were searched till 15th April 2021. All types of studies comparing ESD in the elderly vs non-elderly were included. Subgroup analysis was conducted for the following groups: ≥80 years vs &lt;80 years, ≥75 years vs &lt; 75 years, and ≥65 years vs &lt;65 years.Results17 studies were included. Meta-analysis indicated no statistically significant difference in the en-bloc resection rates (OR: 0.92 95% CI: 0.68, 1.26 I2 = 8% p=0.62) and histological complete resection rates (OR: 0.93 95% CI: 0.75, 1.15 I2 = 26% p=0.50) between elderly and non-elderly patients. The results were non-significant even on subgroup analysis. Overall, we found a non-significant but a tendency of increased perforation rates in the elderly as compared to non-elderly patients (OR: 1.22 95% CI: 0.99, 1.52 I2 = 0% p=0.06). However, there was a significantly increased risk of perforation in elderly patients aged ≥80 years as compared to patients &lt;80 years (OR: 1.50 95% CI: 1.00, 2.24 I2 = 3% p=0.05). Bleeding rates were not different in the two groups (OR: 1.07 95% CI: 0.87, 1.32 I2 = 19% p=0.52). Pooled analysis indicated a statistically significantly increased risk of pneumonia in elderly patients (OR: 2.52 95% CI: 1.72, 3.70 I2 = 7% p&lt;0.00001). Length of hospital stay was reported only by five studies. Meta-analysis indicated no significant difference between the two study groups (MD: 0.67 95% CI: -0.14, 1.48 I2 = 83% p=0.10).ConclusionEn-bloc and histological complete resection rates do not differ between elderly and non-elderly patients undergoing ESD for early gastric cancer. Elderly patients have a small tendency of increased risk of perforation with significantly increased rates in the super-elderly (≥80 years of age). The risk of pneumonia is significantly higher in elderly patients but the rates of bleeding do not differ. The certainty of evidence is “very low” and there is a need for high-quality studies taking into account confounding factors to enhance the quality of evidence.

TLR1 and PRKAA1 Gene Polymorphisms in the Development of Atrophic Gastritis and Gastric Cancer

2018 ◽  
Vol 27 (4) ◽  
pp. 363-369 ◽  
Author(s):  
Gintare Dargiene ◽  
Greta Streleckiene ◽  
Jurgita Skieceviciene ◽  
Marcis Leja ◽  
Alexander Link ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Atrophic Gastritis ◽  
Genetic Polymorphisms ◽  
Association Studies ◽  
Control Group ◽  
Similar Distribution ◽  
Genome Wide Association Studies ◽  
Increased Risk ◽  
Infection Susceptibility ◽  
H Pylori

Background & Aims: Previous genome-wide association studies showed that genetic polymorphisms in toll-like receptor 1 (TLR1) and protein kinase AMP-activated alpha 1 catalytic subunit (PRKAA1) genes were associated with gastric cancer (GC) or increased Helicobacter pylori (H. pylori) infection susceptibility. The aim of this study was to evaluate the association between TLR1 and PRKAA1 genes polymorphisms and H.pylori infection, atrophic gastritis (AG) or GC in the European population.Methods: Single-nucleotide polymorphisms (SNPs) were analysed in 511 controls, 340 AG patients and 327 GC patients. TLR1 C>T (rs4833095) and PRKAA1 C>T (rs13361707) were genotyped by the real-time polymerase chain reaction. H. pylori status was determined by testing for anti-H. pylori IgG antibodies in the serum.Results: The study included 697 (59.2%) H. pylori positive and 481 (40.8%) H. pylori negative cases. We observed similar distribution of TLR1 and PRKAA1 alleles and genotypes in H. pylori positive and negative cases. TLR1 and PRKAA1 SNPs were not linked with the risk of AG. TC genotype of TLR1 gene was more prevalent in GC patients compared to the control group (29.7% and 22.3% respectively, p=0.002). Carriers of TC genotype had a higher risk of GC (aOR=1.89, 95% CI: 1.26–2.83, p=0.002). A similar association was observed in a dominant inheritance model for TLR1 gene SNP, where comparison of CC+TC vs. TT genotypes showed an increased risk of GC (aOR=1.86, 95% CI: 1.26–2.75, p=0.002). No association between genetic polymorphism in PRKAA1 gene and GC was observed.Conclusions: TLR1 rs4833095 SNP was associated with an increased risk of GC in a European population, while PRKAA1 rs13361707 genetic variant was not linked with GC. Both genetic polymorphisms were not associated with H. pylori infection susceptibility or the risk of AG.

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