scholarly journals Factors associated with neonatal mortality in the African Great Lakes region: A pooled analysis of national surveys

2019 ◽  
Author(s):  
Blessing Jaka Akombi ◽  
Pramesh Raj Ghimire ◽  
Andre Masumbuko Renzaho
Keyword(s):  
Great Lakes ◽  
Neonatal Mortality ◽  
Pooled Analysis ◽  
Great Lakes Region ◽  
African Great Lakes ◽  
National Surveys ◽  
Factors Associated

scholarly journals Stillbirth in the African Great Lakes region: A pooled analysis of Demographic and Health Surveys

PLoS ONE ◽  
2018 ◽  
Vol 13 (8) ◽  
pp. e0202603 ◽  
Author(s):  
Blessing Jaka Akombi ◽  
Pramesh Raj Ghimire ◽  
Kingsley Emwinyore Agho ◽  
Andre Masumbuko Renzaho
Keyword(s):  
Great Lakes ◽  
Health Surveys ◽  
Pooled Analysis ◽  
Demographic And Health Surveys ◽  
Great Lakes Region ◽  
African Great Lakes

scholarly journals A sister lineage of the Mycobacterium tuberculosis complex discovered in the African Great Lakes region

2020 ◽  
Author(s):  
Jean Claude Semuto Ngabonziza ◽  
Chloé Loiseau ◽  
Michael Marceau ◽  
Agathe Jouet ◽  
Fabrizio Menardo ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Great Lakes ◽  
Mycobacterium Tuberculosis Complex ◽  
Phylogenetic Reconstruction ◽  
Multidrug Resistant ◽  
Great Lakes Region ◽  
Tuberculosis Complex ◽  
Genome Region ◽  
African Great Lakes ◽  
Molecular Events

AbstractThe human- and animal-adapted lineages of the Mycobacterium tuberculosis complex (MTBC) are thought to have clonally expanded from a common progenitor in Africa. However, the molecular events that accompanied this emergence remain largely unknown. Here, we describe two MTBC strains isolated from patients with multidrug-resistant tuberculosis, representing an as-yet-unknown lineage, named Lineage 8 (L8), seemingly restricted to the African Great Lakes region. Using genome-based phylogenetic reconstruction, we show that L8 is a sister clade to the known MTBC lineages. Comparison with other complete mycobacterial genomes indicate that the divergence of L8 preceded the loss of the cobF genome region - involved in the cobalamin/vitamin B12 synthesis - and gene interruptions in a subsequent common ancestor shared by all other known MTBC lineages. This discovery further supports an East African origin for the MTBC and provides additional molecular clues on the ancestral genome reduction associated with adaptation to a pathogenic lifestyle.

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