scholarly journals The Occupational Hazards of Exposure to Antineoplastic and Chemotherapy Drugs in Nurses. A systematic review

2019 ◽  
Vol 1 (3) ◽  
pp. 20-28
Author(s):  
N Nejat1 ◽  
F Mehrabi ◽  
◽  
Keyword(s):  
Systematic Review ◽  
Occupational Hazards ◽  
Chemotherapy Drugs

A systematic review on informal waste picking: Occupational hazards and health outcomes

2021 ◽  
Vol 126 ◽  
pp. 291-308
Author(s):  
Tara Rava Zolnikov ◽  
Frances Furio ◽  
Vanessa Cruvinel ◽  
June Richards
Keyword(s):  
Systematic Review ◽  
Health Outcomes ◽  
Occupational Hazards

scholarly journals Clinical Theragnostic Potential of Diverse miRNA Expressions in Prostate Cancer: A Systematic Review and Meta-Analysis

Cancers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1199 ◽  
Author(s):  
Rama Jayaraj ◽  
Greg Raymond ◽  
Sunil Krishnan ◽  
Katherine S. Tzou ◽  
Siddhartha Baxi ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Systematic Review ◽  
Meta Analysis ◽  
Bibliographic Databases ◽  
Prognostic Impact ◽  
Eligibility Criteria ◽  
Chemotherapy Drugs ◽  
Newcastle Ottawa Scale ◽  
Methodological Assessment ◽  
Trim And Fill

Background: Prostate cancer (PrC) is the second-most frequent cancer in men, its incidence is emerging globally and is the fifth leading cause of death worldwide. While diagnosis and prognosis of PrC have been studied well, the associated therapeutic biomarkers have not yet been investigated comprehensively. This systematic review and meta-analysis aim to evaluate the theragnostic effects of microRNA expressions on chemoresistance in prostate cancer and to analyse the utility of miRNAs as clinical theragnostic biomarkers. Methods: A systematic literature search for studies reporting miRNA expressions and their role in chemoresistance in PrC published until 2018 was collected from bibliographic databases. The evaluation of data was performed as per PRISMA guidelines for systematic review and meta-analysis. Meta-analysis was performed using a random-effects model using Comprehensive Meta-Analysis (CMA) software. Heterogeneity between studies was analysed using Cochran’s Q test, I2 and the Tau statistic. Quality assessment of the studies was performed using the Newcastle–Ottawa Scale (NOS) for the methodological assessment of cohort studies. Publication bias was assessed using Egger’s bias indicator test, Orwin and classic fail-safe N test, Begg and Mazumdar rank collection test, and Duval and Tweedie’s trim and fill methods. Findings: Out of 2909 studies retrieved, 79 studies were shortlisted and reviewed. A total of 17 studies met our eligibility criteria, from which 779 PrC patients and 17 chemotherapy drugs were examined, including docetaxel and paclitaxel. The majority of the drug regulatory genes reported were involved in cell survival, angiogenesis and cell proliferation pathways. We studied 42 miRNAs across all studies, out of which two miRNAs were found to be influencing chemosensitivity, while 21 were involved in chemoresistance. However, the remaining 19 miRNAs did not appear to have any theragnostic effects. Besides, the prognostic impact of the miRNAs was evaluated and had a pooled HR value of 1.960 with 95% CI (1.377–2.791). Interpretation: The observation of the current study depicts the significance of miRNA expression as a theragnostic biomarker in medical oncology. This review suggests the involvement of specific miRNAs as predictors of chemoresistance and sensitivity in PrC. Hence, the current systematic review and meta-analysis provide insight on the use of miRNA as PrC biomarkers, which can be harnessed as molecular candidates for therapeutic targeting.

scholarly journals Robotics in neurointerventional surgery: a systematic review of the literature

2021 ◽  
pp. neurintsurg-2021-018096
Author(s):  
William Crinnion ◽  
Ben Jackson ◽  
Avnish Sood ◽  
Jeremy Lynch ◽  
Christos Bergeles ◽  
...  
Keyword(s):  
Systematic Review ◽  
Carotid Artery ◽  
Success Rate ◽  
Cerebral Angiography ◽  
Clinical Success ◽  
Robotic Systems ◽  
Occupational Hazards ◽  
Review Of The Literature ◽  
Neurointerventional Procedures ◽  
Manual Assistance

BackgroundRobotically performed neurointerventional surgery has the potential to reduce occupational hazards to staff, perform intervention with greater precision, and could be a viable solution for teleoperated neurointerventional procedures.ObjectiveTo determine the indication, robotic systems used, efficacy, safety, and the degree of manual assistance required for robotically performed neurointervention.MethodsWe conducted a systematic review of the literature up to, and including, articles published on April 12, 2021. Medline, PubMed, Embase, and Cochrane register databases were searched using medical subject heading terms to identify reports of robotically performed neurointervention, including diagnostic cerebral angiography and carotid artery intervention.ResultsA total of 8 articles treating 81 patients were included. Only one case report used a robotic system for intracranial intervention, the remaining indications being cerebral angiography and carotid artery intervention. Only one study performed a comparison of robotic and manual procedures. Across all studies, the technical success rate was 96% and the clinical success rate was 100%. All cases required a degree of manual assistance. No studies had clearly defined patient selection criteria, reference standards, or index tests, preventing meaningful statistical analysis.ConclusionsGiven the clinical success, it is plausible that robotically performed neurointerventional procedures will eventually benefit patients and reduce occupational hazards for staff; however, there is no high-level efficacy and safety evidence to support this assertion. Limitations of current robotic systems and the challenges that must be overcome to realize the potential for remote teleoperated neurointervention require further investigation.

scholarly journals Multiple Exposures and Coexposures to Occupational Hazards Among Agricultural Workers: A Systematic Review of Observational Studies

2018 ◽  
Vol 9 (3) ◽  
pp. 239-248 ◽  
Author(s):  
Thi-Hai-Yen Nguyen ◽  
Mélanie Bertin ◽  
Julie Bodin ◽  
Natacha Fouquet ◽  
Nathalie Bonvallot ◽  
...  
Keyword(s):  
Systematic Review ◽  
Observational Studies ◽  
Agricultural Workers ◽  
Occupational Hazards ◽  
Multiple Exposures

Systematic review of occupational hazards at postharvest grain operations

2021 ◽  
pp. injuryprev-2021-044273
Author(s):  
Sabrina Dalla Corte Bellochio ◽  
Paulo Carteri Coradi
Keyword(s):  
Systematic Review ◽  
Occupational Safety ◽  
Occupational Hazards ◽  
Occupational Risks ◽  
Safety And Health ◽  
Agricultural Safety ◽  
Monitoring Technologies ◽  
Real Time Information ◽  
And Storage ◽  
Time Information

IntroductionAgriculture stands out in relation to the high number of occupational incidents and diseases. In this sense, grains postharvest operations, such as receiving, precleaning, drying, storage and shipping the grains, are highlighted in the number of injuries and fatalities.AimTo identify and extract qualitative and quantitative data related to the main occupational hazards present in grains postharvest operations at preprocessing and storage facilities.MethodsA systematic review was carried out in the databases of Science Direct, Scopus and Web of Science for papers published between 1980 and 2019. The abstract should have described a study related to any occupational hazard (physical, chemical, biological, ergonomic and mechanical) and at least one of the occupational hazards should be related to any postharvest operations.Results and discussionsIn total, 42% of 38 analysed papers were published between 2015 and 2019. Three journals were responsible for 45% of publications related to occupational hazards present in grains postharvest operations. The most part of analysed publications related to confined spaces, grain entrapment, machine entanglement and falls hazards are related to Purdue University’s Agricultural Safety and Health Program which applied research in occupational safety at grains postharvest.ConclusionsThe creation of standardised internationals can collaborate to reduce occupational risks in grain storage units. It is suggested the development of monitoring technologies to obtain real-time information on noise, dust, gases and heat in postharvest operations and equipment. The use of intelligent algorithms can create prevention mechanisms for possible occupational risks and avoid injuries to employees.

Epidemiology, Risk Factors and Occupational Hazards—A Systematic Review

2019 ◽  
pp. 49-51
Author(s):  
Sanchia S. Goonewardene ◽  
Raj Persad ◽  
Hanif Motiwala ◽  
David Albala
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Occupational Hazards

scholarly journals Can environmental or occupational hazards alter the sex ratio at birth? A systematic review

2011 ◽  
Vol 4 (1) ◽  
pp. 7109 ◽  
Author(s):  
Metrecia L. Terrell ◽  
Kathleen P. Hartnett ◽  
Michele Marcus
Keyword(s):  
Systematic Review ◽  
Sex Ratio ◽  
Occupational Hazards ◽  
Sex Ratio At Birth

scholarly journals A Systematic Review of Nutritional Lab Correlates with Chemotherapy Induced Peripheral Neuropathy

2022 ◽  
Vol 11 (2) ◽  
pp. 355
Author(s):  
Cindy Tofthagen ◽  
Mary Tanay ◽  
Adam Perlman ◽  
Jason Starr ◽  
Pooja Advani ◽  
...  
Keyword(s):  
Systematic Review ◽  
Peripheral Neuropathy ◽  
Good Evidence ◽  
Cancer Treatments ◽  
Chemotherapy Drugs ◽  
Low Levels ◽  
The Relationship ◽  
Common Laboratory ◽  
Laboratory Measures

Chemotherapy induced peripheral neuropathy (CIPN) is a dose-limiting side effect of chemotherapy for which no prevention or cure exists. Cancer and cancer treatments can adversely affect nutritional status. Nutrition may play a role in development of CIPN, yet the relationship between nutrition and CIPN is not well understood. Common laboratory values measuring various aspects of nutrition (hemoglobin/hematocrit, vitamin B12, calcium, and magnesium) may be associated with CIPN. The aim of this systematic review is to evaluate the empirical evidence surrounding the relationship between laboratory measures of nutrition and CIPN among persons with cancer who received neurotoxic chemotherapy drugs. We conducted an extensive review of the literature to identify articles that evaluated relationships between laboratory measures of nutrition and CIPN. A total of eleven articles satisfied the inclusion/exclusion criteria. Participants in the studies had breast or colorectal cancer, lymphoma or multiple myeloma and were receiving a variety of neurotoxic drugs. Hemoglobin/hematocrit, vitamin D, albumin, and magnesium were associated with CIPN. The quality of the studies ranges from fair to good. Evidence suggests that low levels of the above-mentioned tests could be associated with CIPN but additional research is needed.

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