scholarly journals Protective effect of Enhydra fluctuans DC. aerial against insulitis in alloxan-induced diabetic rats

2022 ◽  
Vol 26(1) (26(1)) ◽  
pp. 1197-1205
Author(s):  
Rina DELFITA ◽  
Dahelmi DAHELMI ◽  
Djong Hon TJONG ◽  
Suhatri SUHATRI
Keyword(s):  
Protective Effect ◽  
Diabetic Rats

Testicular Injury Attenuated by Rapamycin Through Induction of Autophagy and Inhibition of Endoplasmic Reticulum Stress in Streptozotocin- Induced Diabetic Rats

2019 ◽  
Vol 19 (5) ◽  
pp. 665-675 ◽  
Author(s):  
Wenjiao Shi ◽  
Zhixin Guo ◽  
Ruixia Yuan
Keyword(s):  
Oxidative Stress ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Protective Effect ◽  
Er Stress ◽  
B Cell Lymphoma ◽  
Diabetic Rats ◽  
Pathological Changes ◽  
Rapamycin Treatment ◽  
Related Proteins

Background and Objective: This study investigated whether rapamycin has a protective effect on the testis of diabetic rats by regulating autophagy, endoplasmic reticulum stress, and oxidative stress. Methods: Thirty male Sprague-Dawley rats were randomly divided into three groups: control, diabetic, and diabetic treated with rapamycin, which received gavage of rapamycin (2mg.kg-1.d-1) after induction of diabetes. Diabetic rats were induced by intraperitoneal injection of streptozotocin (STZ, 65mg.Kg-1). All rats were sacrificed at the termination after 8 weeks of rapamycin treatment. The testicular pathological changes were determined by hematoxylin and eosin staining. The protein or mRNA expression of autophagy-related proteins (Beclin1, microtubule-associated protein light chain 3 (LC3), p62), ER stress marked proteins (CCAAT/enhancer-binding protein (C/EBP) homologous protein (CHOP), caspase-12), oxidative stress-related proteins (p22phox, nuclear factor erythroid2-related factor 2 (Nrf2)) and apoptosis-related proteins (Bax, B cell lymphoma-2 (Bcl-2)) were assayed by western blot or real-time fluorescence quantitative PCR. Results: There were significant pathological changes in the testes of diabetic rats. The expression of Beclin1, LC3, Nrf2, Bcl-2 were significantly decreased and p62, CHOP, caspase12, p22phox, and Bax were notably increased in the testis of diabetic rats (P <0.05). However, rapamycin treatment for 8 weeks significantly reversed the above changes in the testis of diabetic rats (P <0.05). Conclusion: Rapamycin appears to produce a protective effect on the testes of diabetic rats by inducing the expression of autophagy and inhibiting the expression of ER-stress, oxidative stress, and apoptosis.

Protective effect of ginsenoside Rg3 on lung injury in diabetic rats

2018 ◽  
Vol 120 (3) ◽  
pp. 3323-3330 ◽  
Author(s):  
Heyuan Wang ◽  
Wei Wu ◽  
Guixia Wang ◽  
Wenzhou Xu ◽  
Fuqiang Zhang ◽  
...  
Keyword(s):  
Lung Injury ◽  
Protective Effect ◽  
Diabetic Rats ◽  
Ginsenoside Rg3

scholarly journals Protective effect of distillated Nerium oleander on heart of type 2 diabetic rats

2015 ◽  
Vol 116 (07) ◽  
pp. 451-456
Author(s):  
M. Ayaz ◽  
F. Baba ◽  
N. Akgun ◽  
A. L. Bas ◽  
K. Uney ◽  
...  
Keyword(s):  
Protective Effect ◽  
Diabetic Rats ◽  
Nerium Oleander ◽  
Type 2 Diabetic

scholarly journals Short-Term Feeding of Fibre-Enriched Biscuits: Protective Effect against Hepatotoxicity in Diabetic Rats

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Ochuko L. Erukainure ◽  
Osaretin A. T. Ebuehi ◽  
Folasade O. Adeboyejo ◽  
Olufunmilola O. Oladunmoye ◽  
Muhammad Aliyu ◽  
...  
Keyword(s):  
Protective Effect ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hepatic Function ◽  
Treated Group ◽  
Albumin Level ◽  
Diabetic Rats ◽  
Protein Levels ◽  
Significant Difference ◽  
Alloxan Monohydrate

The effects of fibre-enriched biscuit on biomarkers associated with hepatotoxicity in diabetic rats were investigated. Diabetes was induced by single intraperitoneal injection of alloxan monohydrate. Treatment lasted for 14 days after which the rats were sacrificed by cervical dislocation. Blood serum was analyzed to determine hepatic function enzymes. The liver was also analyzed to determine hepatic lipid profile and antioxidant enzymes. Induction of diabetes led to elevated levels of ALP, AST, and ALT. These were, however, significantly (p<0.05) reduced in the fibre-enriched biscuit fed (treated) group. There was no significant difference in the serum bilirubin and total protein levels of the studied groups. Reduced albumin level was observed in the diabetic group; this was further lowered on feeding with fibre-enriched biscuits. Induction of diabetes led to increased hepatic level of cholesterol, triglyceride (TG), low density lipoprotein (LDL), and lipid peroxidation and decreased activities of glutathione (GSH), catalase (CAT), and superoxide dismutase (SOD) and HDL level. These were significantly (p<0.05) reversed on feeding with fibre-enriched biscuit. This study portrays the protective effect of fibre-enriched biscuit on increased oxidative stress and hyperlipidemia in hepatic tissues of alloxan-induced diabetic rats.

scholarly journals Protective effect of aqueous extracts from Canarium odontophyllum Miq. leaf on liver in streptozotocin-induced diabetic rats

2018 ◽  
Vol 2 (1) ◽  
Author(s):  
Siti Balkis Budin ◽  
Shashi Kumar ◽  
Nor Malia Abd Warif ◽  
Shafikha Mohd Saari ◽  
Dayang Fredalina Basri
Keyword(s):  
Protective Effect ◽  
Diabetic Rats ◽  
Aqueous Extracts ◽  
Canarium Odontophyllum
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