scholarly journals Different Effects of the Insulin Receptor Isoforms on 32D Cell Growth and Differentiation

2017 ◽  
pp. 1-9 ◽  
Keyword(s):  
Cell Growth ◽  
Insulin Receptor ◽  
Receptor Isoforms ◽  
Insulin Receptor Isoforms ◽  
Cell Growth And Differentiation

scholarly journals Insulin Receptor Isoforms in Cancer

2018 ◽  
Vol 19 (11) ◽  
pp. 3615 ◽  
Author(s):  
Veronica Vella ◽  
Agostino Milluzzo ◽  
Nunzio Scalisi ◽  
Paolo Vigneri ◽  
Laura Sciacca
Keyword(s):  
Insulin Receptor ◽  
Cancer Cells ◽  
Predictive Biomarker ◽  
Point Of View ◽  
Receptor Isoforms ◽  
Insulin Receptor Isoforms ◽  
Target Therapies ◽  
Isoform Expression ◽  
Exon 11 ◽  
Clinical Conditions

The insulin receptor (IR) mediates both metabolic and mitogenic effects especially when overexpressed or in clinical conditions with compensatory hyperinsulinemia, due to the metabolic pathway resistance, as obesity diabetes. In many cancers, IR is overexpressed preferentially as IR-A isoform, derived by alternative splicing of exon 11. The IR-A overexpression, and the increased IR-A:IR-B ratio, are mechanisms that promote the mitogenic response of cancer cells to insulin and IGF-2, which is produced locally by both epithelial and stromal cancer cells. In cancer IR-A, isoform predominance may occur for dysregulation at both mRNA transcription and post-transcription levels, including splicing factors, non-coding RNAs and protein degradation. The mechanisms that regulate IR isoform expression are complex and not fully understood. The IR isoform overexpression may play a role in cancer cell stemness, in tumor progression and in resistance to target therapies. From a clinical point of view, the IR-A overexpression in cancer may be a determinant factor for the resistance to IGF-1R target therapies for this issue. IR isoform expression in cancers may have the meaning of a predictive biomarker and co-targeting IGF-1R and IR-A may represent a new more efficacious treatment strategy.

scholarly journals Differential Expression of IGF Components and Insulin Receptor Isoforms in Human Seminoma Versus Normal Testicular Tissue

Neoplasia ◽  
2005 ◽  
Vol 7 (5) ◽  
pp. 446-456 ◽  
Author(s):  
Tanja Pascale Neuvians ◽  
Isabella Gashaw ◽  
Andrea Hasenfus ◽  
Axel Häcker ◽  
Elke Winterhager ◽  
...  
Keyword(s):  
Insulin Receptor ◽  
Differential Expression ◽  
Testicular Tissue ◽  
Receptor Isoforms ◽  
Insulin Receptor Isoforms

scholarly journals IGF1 and IGF2 specificities to the two insulin receptor isoforms are determined by insulin receptor amino acid 718

PLoS ONE ◽  
2017 ◽  
Vol 12 (6) ◽  
pp. e0178885 ◽  
Author(s):  
Mie Andersen ◽  
Dorte Nørgaard-Pedersen ◽  
Jakob Brandt ◽  
Ingrid Pettersson ◽  
Rita Slaaby
Keyword(s):  
Amino Acid ◽  
Insulin Receptor ◽  
Receptor Isoforms ◽  
Insulin Receptor Isoforms

scholarly journals DM1 CTG expansions affect insulin receptor isoforms expression in various tissues of transgenic mice

2007 ◽  
Vol 1772 (11-12) ◽  
pp. 1183-1191 ◽  
Author(s):  
Céline Guiraud-Dogan ◽  
Aline Huguet ◽  
Mário Gomes-Pereira ◽  
Edith Brisson ◽  
Guillaume Bassez ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Insulin Receptor ◽  
Receptor Isoforms ◽  
Insulin Receptor Isoforms
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