scholarly journals Phase Manifestation and Formation of Nanoemulsions Composed of Imidazolium-based Ionic Liquid, Tween 80/Span 80 and Labrafac Lipophile WL 1349

2017 ◽  
Vol 32 (2) ◽  
pp. 85
Author(s):  
S. H. Ng ◽  
P. M. WOI ◽  
C. C. ENG
Keyword(s):  
Ionic Liquid ◽  
Phase Diagrams ◽  
Ternary Phase ◽  
Single Phase ◽  
Tween 80 ◽  
Continuous Phase ◽  
Good Stability ◽  
Sorbitan Monooleate ◽  
Ternary Phase Diagrams ◽  
Span 80

onic liquids (ILs) can enhance topical and transdermal delivery, as well as increase the solubility of sparingly soluble drugs. In the present work, pseudo-ternary phase diagrams of emulsions were composed of a mixture of non-ionic surfactants, polyoxyethylene sorbitan monooleate (Tween 80®) and sorbitan monooleate (Span 80®) in weight fraction: 1:1, 1:2, 2:1 and 2:3, LabrafacTM Lipophile WL 1349 as an oil phase and 1-hexyl-3-methylimidazolium chloride [(HMIM) (Cl)] as a continuous phase. Emulsion formulations were selected with 10% surfactants from the pseudo-ternary phase diagrams and further prepared at 298.2 ± 0.1 K. Acoustic emulsificationmethod was used to prepare nanoemulsions that were mixed with freshly prepared hydrocolloid gum. The area of the single-phase zone in pseudo-ternary phase diagrams that varied with Tween 80® /Span 80® ratio in the order of 2:1 > 1:1 > 2:3 > 1:2 where Span 80® was replaced by an equivalent weight of Tween 80®  to form IL-based nanoemulsions. [HMIM] [Cl] tended to create a two-phase system. Addition of carbopol® ultrez 20 copolymer into the continuous phase of the formulations gave single-phase nanoemulsions with good stability. The mixture of surfactants with weight ratio of 1:2 (Tween 80®/Span 80®) showed a good stability with the smallest particle size and greater surface charges in the system. These ionic liquid-based nanoemulsions might have the potential in drug delivery systems.

Effects of Various Co-Surfactants and Oils on Microemulsion Formation in Decylglucoside System

2013 ◽  
Vol 747 ◽  
pp. 653-656 ◽  
Author(s):  
Natthida Pakpayat ◽  
Prapaporn Boonme
Keyword(s):  
Phase Diagrams ◽  
Ternary Phase ◽  
Isopropyl Myristate ◽  
Ionic Surfactant ◽  
Sorbitan Monooleate ◽  
Ternary Phase Diagrams ◽  
Two Systems ◽  
Low Toxic ◽  
Biodegradable Surfactant

Decylglucoside is a non-ionic, non-toxic, biodegradable surfactant. This work aimed to establish composition where stable microemulsions could form using hydrophilic lipophilic deviation (HLD) concept to optimise the formulations. Scanning for suitable ratios of surfactant and co-surfactant was carried out by altering the surfactant/co-surfactant (S/CoS) ratios with two co-surfactants and seven different oils in order to find the optimum formulations. From the optimal S/CoS ratios, pseudo-ternary phase diagrams by dilution were subsequently performed, leading to obtain microemulsion zones. The zones of microemulsions could be observed in the systems composed of decylglucoside/sorbitan monooleate/isopropyl myristate/water at the 0.10/0.90 and 0.20/0.80 S/CoS ratios and decylglucoside/sorbitan monooleate /isopropyl palmitate/water at the 0.10/0.90, 0.15/0.85 and 0.20/0.80 S/CoS ratios. The microemulsion zones of two systems were similar and found at high surfactant concentrations. However, the studied decylglucoside microemulsion systems were interesting in drug and cosmetic applications because it consisted of non-ionic surfactant and co-surfactant, resulting low toxic products.

The use of acoustic spectroscopy in the characterisation of ternary phase diagrams

2013 ◽  
Vol 441 (1-2) ◽  
pp. 603-610 ◽  
Author(s):  
Giulia Bonacucina ◽  
Marco Cespi ◽  
Giovanna Mencarelli ◽  
Luca Casettari ◽  
Giovanni F. Palmieri
Keyword(s):  
Phase Diagrams ◽  
Ternary Phase ◽  
Ternary Phase Diagrams ◽  
Acoustic Spectroscopy

Effect of short-chain alcohols as co-surfactants on pseudo-ternary phase diagrams containing lecithin

1999 ◽  
Vol 16 (3) ◽  
pp. 377-381 ◽  
Author(s):  
Suk-Young Choi ◽  
Seong-Geun Oh ◽  
Seong-Youl Bae ◽  
Sei-Ki Moon
Keyword(s):  
Phase Diagrams ◽  
Ternary Phase ◽  
Short Chain ◽  
Ternary Phase Diagrams

scholarly journals A New 1:1 Drug-Drug Cocrystal of Theophylline and Aspirin: Discovery, Characterization, and Construction of Ternary Phase Diagrams

2018 ◽  
Vol 18 (12) ◽  
pp. 7526-7532 ◽  
Author(s):  
Shaza Darwish ◽  
Jacek Zeglinski ◽  
Gamidi Rama Krishna ◽  
Rahamatullah Shaikh ◽  
Majeda Khraisheh ◽  
...  
Keyword(s):  
Phase Diagrams ◽  
Ternary Phase ◽  
Ternary Phase Diagrams

scholarly journals Ternary Phase Diagrams that Relate to the Plutonium Immobilization Ceramic

2001 ◽  
Author(s):  
B b Ebbinghaus ◽  
O H Krikorian ◽  
E R Vance ◽  
M W Stewart
Keyword(s):  
Phase Diagrams ◽  
Ternary Phase ◽  
Ternary Phase Diagrams

scholarly journals Production, characterization and application of ternary phase diagrams for the purification of biodiesel produced from tropical almond seed oil

2021 ◽  
Vol 39 (4) ◽  
pp. 1066-1075
Author(s):  
K.K. Adama ◽  
U.P. Onochie ◽  
E. Gbeinzi
Keyword(s):  
Phase Diagrams ◽  
Ternary Phase ◽  
Seed Oil ◽  
Ternary Phase Diagram ◽  
Solubility Curve ◽  
Separation And Purification ◽  
Components Separation ◽  
Ternary Phase Diagrams ◽  
C 30 ◽  
Gas Chromatographic Method

This study presents the application of ternary phase diagrams to tropical almond biodiesel components separation and purification at two temperatures. The seed oil was extracted mechanically and alkaline transesterified to produce biodiesel. The oil and biodiesel were characterized using standard methods. Tie lines and binodal solubility curve data were determined using modified cloud point titration procedures. Gas chromatographic method was employed in the analysis of the phase compositions. The mixture of biodiesel, methanol and glycerol were investigated at 20 °C, 30 °C and withdrawal times of 2 to 32 minutes at 2 minutes intervals. Distribution coefficient, K and solvent selectivity, S analysis were performed. Results obtained showed that S > 1 indicating the ability of methanol to promote phase separation and purification. K < 1 implying that there was lower quantities of methanol solubilized in the biodiesel phase. The ternary phase diagrams provided the means of predicting the components distribution. Keywords: Production, Characterization, Tropical Almond Biodiesel, Purification, Ternary Phase Diagram

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