scholarly journals Development of nanogel engineering for new protein drug delivery system and medical applications

2014 ◽  
Vol 29 (4) ◽  
pp. 323-332
Author(s):  
Kazunari Akiyoshi
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Medical Applications ◽  
Protein Drug ◽  
Protein Drug Delivery ◽  
New Protein

A Novel Oral Protein-Drug Delivery System with Bilayer Shell-Core Structure

2020 ◽  
Author(s):  
Xuan Zhang ◽  
Yanjun Tong ◽  
Xiaomei Lyu ◽  
Jianfen Ye ◽  
Ruijin Yang
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Core Structure ◽  
Protein Drug ◽  
Protein Drug Delivery

Multistage pH-responsive mucoadhesive nanocarriers prepared by aerosol flow reactor technology: A controlled dual protein-drug delivery system

Biomaterials ◽  
2015 ◽  
Vol 68 ◽  
pp. 9-20 ◽  
Author(s):  
Neha Shrestha ◽  
Mohammad-Ali Shahbazi ◽  
Francisca Araújo ◽  
Ermei Mäkilä ◽  
Janne Raula ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Flow Reactor ◽  
Protein Drug ◽  
Ph Responsive ◽  
Aerosol Flow ◽  
Reactor Technology ◽  
Protein Drug Delivery

Calcium Alginate Nanoparticles Synthesized Through a Novel Interfacial Cross-Linking Method as a Potential Protein Drug Delivery System

2012 ◽  
Vol 101 (6) ◽  
pp. 2177-2184 ◽  
Author(s):  
Jerry Nesamony ◽  
Priti R. Singh ◽  
Shadia E. Nada ◽  
Zahoor A. Shah ◽  
William M. Kolling
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Calcium Alginate ◽  
Cross Linking ◽  
Protein Drug ◽  
Protein Drug Delivery

Quaternized chitosan (QCS)/poly (aspartic acid) nanoparticles as a protein drug-delivery system

2009 ◽  
Vol 344 (7) ◽  
pp. 908-914 ◽  
Author(s):  
Tie wei Wang ◽  
Qing Xu ◽  
Yan Wu ◽  
Ai jun Zeng ◽  
Mingjun Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Aspartic Acid ◽  
Delivery System ◽  
Protein Drug ◽  
Quaternized Chitosan ◽  
Protein Drug Delivery

scholarly journals Promising Applications of Nanoparticles in the Treatment of Hearing Loss

2021 ◽  
Vol 9 ◽  
Author(s):  
Zilin Huang ◽  
Qiang Xie ◽  
Shuang Li ◽  
Yuhao Zhou ◽  
Zuhong He ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hearing Loss ◽  
Inner Ear ◽  
Drug Delivery System ◽  
Clinical Application ◽  
Delivery System ◽  
Diagnosis And Treatment ◽  
Biological Research ◽  
Medical Applications ◽  
Traditional Treatment

Hearing loss is one of the most common disabilities affecting both children and adults worldwide. However, traditional treatment of hearing loss has some limitations, particularly in terms of drug delivery system as well as diagnosis of ear imaging. The blood–labyrinth barrier (BLB), the barrier between the vasculature and fluids of the inner ear, restricts entry of most blood-borne compounds into inner ear tissues. Nanoparticles (NPs) have been demonstrated to have high biocompatibility, good degradation, and simple synthesis in the process of diagnosis and treatment, which are promising for medical applications in hearing loss. Although previous studies have shown that NPs have promising applications in the field of inner ear diseases, there is still a gap between biological research and clinical application. In this paper, we aim to summarize developments and challenges of NPs in diagnostics and treatment of hearing loss in recent years. This review may be useful to raise otology researchers’ awareness of effect of NPs on hearing diagnosis and treatment.

scholarly journals Photo-Responsive Polymersomes as Drug Delivery System for Potential Medical Applications

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 5147
Author(s):  
Wanting Hou ◽  
Ruiqi Liu ◽  
Siwei Bi ◽  
Qian He ◽  
Haibo Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Drug Delivery System ◽  
Delivery System ◽  
Raft Polymerization ◽  
Amphiphilic Block Copolymers ◽  
Medical Applications ◽  
Drug Molecules ◽  
Reversible Addition ◽  
Raft Agent

Due to a strong retardation effect of o-nitrobenzyl ester on polymerization, it is still a great challenge to prepare amphiphilic block copolymers for polymersomes with a o-nitrobenzyl ester-based hydrophobic block. Herein, we present one such solution to prepare amphiphilic block copolymers with pure poly (o-nitrobenzyl acrylate) (PNBA) as the hydrophobic block and poly (N,N’-dimethylacrylamide) (PDMA) as the hydrophilic block using bulk reversible addition-fragmentation chain transfer (RAFT) polymerization of o-nitrobenzyl acrylate using a PDMA macro-RAFT agent. The developed amphiphilic block copolymers have a suitable hydrophobic/hydrophilic ratio and can self-assemble into photoresponsive polymersomes for co-loading hydrophobic and hydrophilic cargos into hydrophobic membranes and aqueous compartments of the polymersomes. The polymersomes demonstrate a clear photo-responsive characteristic. Exposure to light irradiation at 365 nm can trigger a photocleavage reaction of o-nitrobenzyl groups, which results in dissociation of the polymersomes with simultaneous co-release of hydrophilic and hydrophobic cargoes on demand. Therefore, these polymersomes have great potential as a smart drug delivery nanocarrier for controllable loading and releasing of hydrophilic and hydrophobic drug molecules. Moreover, taking advantage of the conditional releasing of hydrophilic and hydrophobic drugs, the drug delivery system has potential use in medical applications such as cancer therapy.

DRUG DELIVERY THROUGH LIPOSOME BY ULTRASONIC CAVITATION

2001 ◽  
Vol 13 (01) ◽  
pp. 47-52
Author(s):  
PO-LIN CHIU ◽  
CHUNG-YUO WU ◽  
JENHO TSAO ◽  
FU-HSIUNG CHANG
Keyword(s):  
Drug Delivery ◽  
Control System ◽  
Side Effects ◽  
Drug Delivery System ◽  
Power Unit ◽  
Delivery System ◽  
Essential Elements ◽  
Ultrasonic Cavitation ◽  
Medical Applications ◽  
New Drug

Ultrasonic cavitation has found potential usages in medical applications, and we are developing a new drug delivery control system based on liposome and cavitation technology. In order to reduce the side effects of drugs and increase the efficacy of drugs, we combine the advantage of the usage of liposome and ultrasonic cavitation to attain the system. In this system, imaging unit and power unit are essential elements. There are many parameters which need to be controlled. By this drug delivery system, we are to verify its safety and availability. In this paper, we describe how this drug delivery system by ultrasonic cavitation to be designed and evaluated.

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