Calcium Alginate Nanoparticles Synthesized Through a Novel Interfacial Cross-Linking Method as a Potential Protein Drug Delivery System

2012 ◽  
Vol 101 (6) ◽  
pp. 2177-2184 ◽  
Author(s):  
Jerry Nesamony ◽  
Priti R. Singh ◽  
Shadia E. Nada ◽  
Zahoor A. Shah ◽  
William M. Kolling
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Calcium Alginate ◽  
Cross Linking ◽  
Protein Drug ◽  
Protein Drug Delivery

A Novel Oral Protein-Drug Delivery System with Bilayer Shell-Core Structure

2020 ◽  
Author(s):  
Xuan Zhang ◽  
Yanjun Tong ◽  
Xiaomei Lyu ◽  
Jianfen Ye ◽  
Ruijin Yang
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Core Structure ◽  
Protein Drug ◽  
Protein Drug Delivery

Multistage pH-responsive mucoadhesive nanocarriers prepared by aerosol flow reactor technology: A controlled dual protein-drug delivery system

Biomaterials ◽  
2015 ◽  
Vol 68 ◽  
pp. 9-20 ◽  
Author(s):  
Neha Shrestha ◽  
Mohammad-Ali Shahbazi ◽  
Francisca Araújo ◽  
Ermei Mäkilä ◽  
Janne Raula ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Flow Reactor ◽  
Protein Drug ◽  
Ph Responsive ◽  
Aerosol Flow ◽  
Reactor Technology ◽  
Protein Drug Delivery

Quaternized chitosan (QCS)/poly (aspartic acid) nanoparticles as a protein drug-delivery system

2009 ◽  
Vol 344 (7) ◽  
pp. 908-914 ◽  
Author(s):  
Tie wei Wang ◽  
Qing Xu ◽  
Yan Wu ◽  
Ai jun Zeng ◽  
Mingjun Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Aspartic Acid ◽  
Delivery System ◽  
Protein Drug ◽  
Quaternized Chitosan ◽  
Protein Drug Delivery

scholarly journals Microencapsulation Curcuminoids for Effective Delivery in Pharmaceutical Application

Pharmaceutics ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 451 ◽  
Author(s):  
Ang ◽  
Darwis ◽  
Por ◽  
Yam
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Release Kinetics ◽  
Polymer Networks ◽  
Active Agent ◽  
Antibacterial Properties ◽  
Light Sensitivity ◽  
Thick Wall ◽  
Cross Linking

Curcuminoids have been long proven to possess antioxidant, anti-inflammatory and antibacterial properties which are crucial in their role as a pharmacological active agent. However, its poor solubility, high oxidative degradation, light sensitivity and poor bioavailability have been huge hurdles that need to be overcome for it to be administered as an oral or even a topical medication. In this present study, a complex coacervation microencapsulation approach was used to encapsulate the curcuminoids using both gelatin B and chitosan (at the optimum ratio of 30:1% w/w) for a more efficient drug delivery system. Curcuminoids microcapsules (CPM) were developed to be spherical in shape, discrete and free flowing with a reduced color staining effect. The thick wall of the CPM contributes directly to its integrity and stability. Cross-linking increases the density of polymers’ wall network, hence, further increasing the decomposition temperature of curcuminoids microcapsules. Microencapsulation demonstrated an increment in curcuminoids solubility, while chemical cross-linking allowed for sustained release of the drug from the microcapsules by lowering the swelling rate of the available polymer networks. Thus, the microcapsules complied with the zero order release kinetics with super case-II transport mechanism. On the basis of all that was discussed above, it can be safely concluded that CPM should be incorporated in delivery system of curcuminoid, especially in its topical delivery for controlled drug release purposes, for not only a more efficient drug delivery system design but also a more efficacious optimization of the pharmacological benefits of curcuminoids.

scholarly journals Preparation of insulin loaded chitosan- TPP nanoparticles by ionic gelation method

2015 ◽  
Vol 18 (3) ◽  
pp. 125-134
Author(s):  
Trang Thi Huyen Dinh ◽  
Hao Duc Nguyen ◽  
Hieu Van Le ◽  
Ha Thanh Ho
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Concentration Ratio ◽  
Sodium Tripolyphosphate ◽  
Chitosan Nanoparticles ◽  
Entrapment Efficiency ◽  
Cross Linking ◽  
Ionic Gelation ◽  
Chitosan Concentration

In study, insulin loaded chitosan nanoparticles were prepared via ionic gelation method using cross-linking agent sodium tripolyphosphate (STPP). To have best result for the preparation of nanoparticles, a commercial chitosan with a degree of deacetylation DD of 75 % was adjusted to 85 % - 90 % which was determined by FTIR method. The obtained deacetylated chitosan was studied for the effect of pH, concentration, ratio of chitosan and STPP. Then the insulin loaded chitosan TPP nanoparticles were prepared by ionic gelation method. These nanoparticles could deliver 91.6 % insulin at pH = 3.5, with the chitosan concentration of 1 mg/mL and the chitosan:STPP ratio of 4:1. The TEMs indicate that chitosan nanoparticles were spherical in shape and the particles size was smaller than 100 nm. Investigation of FTIR and entrapment efficiency assert that insulin loaded chitosan nanopartiles have been prepared and can become a drug delivery system via oral in the future.

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