Virtual Reality publication of spiral CT-derived three-dimensional models

10.2741/a235 ◽  
1997 ◽  
Vol 2 (6) ◽  
pp. f2-3 ◽  
Author(s):  
J. M Tyszka
2019 ◽  
Vol 3 (11) ◽  
pp. 176
Author(s):  
Salvatore Orlando ◽  
Ignazio Pillitteri ◽  
Fabrizio Bocchino ◽  
Laura Daricello ◽  
Laura Leonardi

2015 ◽  
Vol 6 (1) ◽  
pp. 1
Author(s):  
Alberto Raposo

The year of 2015 starts with the first issue of JIS dedicated to HCI. The journal was created in 2008, within the scope of the Brazilian Virtual Reality community, and in 2013 and 2014 it made an approximation with the Games and HCI communities, becoming the first periodic in Brazil specifically on these areas. We believe this way the journal may open the door for more interdisciplinary research.This issue contains extended versions of five papers selected among the best full papers of IHC 2014 - XIII Brazilian Symposium on Human Factors in Computer Systems. I would like to thank Carla Leitão, Cristiano Maciel, and Simone Barbosa for their dedication acting as guest editors for this special issue, and invite you to read their editorial in the following.We also have in this issue an original paper by José Paulo de Lima and Helton Bíscaro, entitled "Compressive Representation of Three-dimensional Models''. The authors investigate the applicability of a recent approach to the theory of signs, called Compressive Sensing, to obtain a compressive representation of geometric meshes.I would like to thank the authors and reviewers that contributed to this issue of JIS, and I hope it fulfills your expectations. JIS Editorial Board is looking forward to receiving your contributions.


1975 ◽  
Vol 39 (8) ◽  
pp. 544-546
Author(s):  
HL Wakkerman ◽  
GS The ◽  
AJ Spanauf

2020 ◽  
Vol 17 (4) ◽  
pp. 342-351
Author(s):  
Sergio A. Durán-Pérez ◽  
José G. Rendón-Maldonado ◽  
Lucio de Jesús Hernandez-Diaz ◽  
Annete I. Apodaca-Medina ◽  
Maribel Jiménez-Edeza ◽  
...  

Background: The protozoan Giardia duodenalis, which causes giardiasis, is an intestinal parasite that commonly affects humans, mainly pre-school children. Although there are asymptomatic cases, the main clinical features are chronic and acute diarrhea, nausea, abdominal pain, and malabsorption syndrome. Little is currently known about the virulence of the parasite, but some cases of chronic gastrointestinal alterations post-infection have been reported even when the infection was asymptomatic, suggesting that the cathepsin L proteases of the parasite may be involved in the damage at the level of the gastrointestinal mucosa. Objective: The aim of this study was the in silico identification and characterization of extracellular cathepsin L proteases in the proteome of G. duodenalis. Methods: The NP_001903 sequence of cathepsin L protease from Homo sapienswas searched against the Giardia duodenalisproteome. The subcellular localization of Giardia duodenaliscathepsin L proteases was performed in the DeepLoc-1.0 server. The construction of a phylogenetic tree of the extracellular proteins was carried out using the Molecular Evolutionary Genetics Analysis software (MEGA X). The Robetta server was used for the construction of the three-dimensional models. The search for possible inhibitors of the extracellular cathepsin L proteases of Giardia duodenaliswas performed by entering the three-dimensional structures in the FINDSITEcomb drug discovery tool. Results: Based on the amino acid sequence of cathepsin L from Homo sapiens, 8 protein sequences were identified that have in their modular structure the Pept_C1A domain characteristic of cathepsins and two of these proteins (XP_001704423 and XP_001704424) are located extracellularly. Threedimensional models were designed for both extracellular proteins and several inhibitory ligands with a score greater than 0.9 were identified. In vitrostudies are required to corroborate if these two extracellular proteins play a role in the virulence of Giardia duodenalisand to discover ligands that may be useful as therapeutic targets that interfere in the mechanism of pathogenesis generated by the parasite. Conclusion: In silicoanalysis identified two proteins in the Giardia duodenalisprotein repertoire whose characteristics allowed them to be classified as cathepsin L proteases, which may be secreted into the extracellular medium to act as virulence factors. Three-dimensional models of both proteins allowed the identification of inhibitory ligands with a high score. The results suggest that administration of those compounds might be used to block the endopeptidase activity of the extracellular cathepsin L proteases, interfering with the mechanisms of pathogenesis of the protozoan parasite Giardia duodenalis.


2011 ◽  
Vol 49 (4) ◽  
pp. 326-327 ◽  
Author(s):  
Karen A. Eley ◽  
Robin Richards ◽  
Dermot Dobson ◽  
Alf Linney ◽  
Stephen R. Watt-Smith

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